DHE5_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHE5_YEAST
• UniProt AC: P39708
• Protein Name: NADP-specific glutamate dehydrogenase 2
• Gene Name: GDH3
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 457
• Protein Sequence: MTSEPEFQQAYDEIVSSVEDSKIFEKFPQYKKVLPIVSVPERIIQFRVTWENDNGEQEVAQGYRVQFNSAKGPYKGGLRFHPSVNLSILKFLGFEQIFKNALTGLDMGGGKGGLCVDLKGKSDNEIRRICYAFMRELSRHIGKDTDVPAGDIGVGGREIGYLFGAYRSYKNSWEGVLTGKGLNWGGSLIRPEATGFGLVYYTQAMIDYATNGKESFEGKRVTISGSGNVAQYAALKVIELGGIVVSLSDSKGCIISETGITSEQIHDIASAKIRFKSLEEIVDEYSTFSESKMKYVAGARPWTHVSNVDIALPCATQNEVSGDEAKALVASGVKFVAEGANMGSTPEAISVFETARSTATNAKDAVWFGPPKAANLGGVAVSGLEMAQNSQKVTWTAERVDQELKKIMINCFNDCIQAAQEYSTEKNTNTLPSLVKGANIASFVMVADAMLDQGDVF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Ubiquitination	FEKFPQYKKVLPIVS HHHCCHHCEEEEEEE	31.03	15699485
32	Ubiquitination	EKFPQYKKVLPIVSV HHCCHHCEEEEEEEC	44.03	24961812
71	Ubiquitination	RVQFNSAKGPYKGGL EEEECCCCCCCCCCC	61.31	22817900
75	Ubiquitination	NSAKGPYKGGLRFHP CCCCCCCCCCCCCCC	50.03	23749301
83	Phosphorylation	GGLRFHPSVNLSILK CCCCCCCCCCHHHHH	18.31	24961812
87	Phosphorylation	FHPSVNLSILKFLGF CCCCCCHHHHHHHCH	22.22	24961812
90	Ubiquitination	SVNLSILKFLGFEQI CCCHHHHHHHCHHHH	36.55	23749301
99	Ubiquitination	LGFEQIFKNALTGLD HCHHHHHHHHHCCCC	42.83	17644757
143	Ubiquitination	ELSRHIGKDTDVPAG HHHHHHCCCCCCCCC	57.77	15699485
170	Ubiquitination	FGAYRSYKNSWEGVL HHCHHCCCCCCEEEE	45.83	17644757
172	Phosphorylation	AYRSYKNSWEGVLTG CHHCCCCCCEEEEEC	23.50	22369663
178	Phosphorylation	NSWEGVLTGKGLNWG CCCEEEEECCCCCCC	34.15	22369663
180	Ubiquitination	WEGVLTGKGLNWGGS CEEEEECCCCCCCCC	55.80	17644757
215	Phosphorylation	YATNGKESFEGKRVT HHHCCCCCCCCCEEE	31.89	27017623
219	Ubiquitination	GKESFEGKRVTISGS CCCCCCCCEEEEECC	36.18	17644757
222	Phosphorylation	SFEGKRVTISGSGNV CCCCCEEEEECCCCH	17.29	22369663
224	Phosphorylation	EGKRVTISGSGNVAQ CCCEEEEECCCCHHH	19.96	22369663
226	Phosphorylation	KRVTISGSGNVAQYA CEEEEECCCCHHHHH	22.02	22369663
232	Phosphorylation	GSGNVAQYAALKVIE CCCCHHHHHEEEEEE	5.54	22369663
236	Ubiquitination	VAQYAALKVIELGGI HHHHHEEEEEEECCE	36.12	17644757
289	Phosphorylation	VDEYSTFSESKMKYV HHHHHCCCHHHHHHH	40.84	28889911
357	Phosphorylation	SVFETARSTATNAKD HHHHHHHHHCCCCCC	21.67	25533186

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHE5_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHE5_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHE5_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GLT1_YEAST	GLT1	genetic	16941010
DHE2_YEAST	GDH2	genetic	23105103
APC11_YEAST	APC11	genetic	27708008
NBP35_YEAST	NBP35	genetic	27708008
TAD3_YEAST	TAD3	genetic	27708008
RIB2_YEAST	RIB2	genetic	27708008
ORC4_YEAST	ORC4	genetic	27708008
REI1_YEAST	REI1	genetic	27708008
YFF2_YEAST	YFL052W	genetic	27708008
ATC1_YEAST	PMR1	genetic	27708008
HUR1_YEAST	HUR1	genetic	27708008
STF2_YEAST	STF2	genetic	27708008
THIK_YEAST	POT1	genetic	27708008
MRT4_YEAST	MRT4	genetic	27708008
UBX2_YEAST	UBX2	genetic	27708008
YNO0_YEAST	YNL140C	genetic	27708008
INO4_YEAST	INO4	genetic	27708008
KTR1_YEAST	KTR1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.