NEJ1_YEAST - dbPTM
NEJ1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NEJ1_YEAST
UniProt AC Q06148
Protein Name Non-homologous end-joining protein 1
Gene Name NEJ1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 342
Subcellular Localization Cytoplasm . Nucleus membrane
Multi-pass membrane protein .
Protein Description Involved in non-homologous end joining (NHEJ). Facilitates the transport of LIF1 into the nucleus, where it can interact with DNA ligase DNL4 to repair double-strand breaks (DSB). Mediates mating-type regulation of NHEJ. Prevents chromosome circularisation by NHEJ in absence of telomerase..
Protein Sequence MDSELKGQQLSDAEWCVKKINGEGNCLLLFLPMSSPTTIVMIVLVSLERLVPYVFKLSQTQLSQQCQSQGFTDSISLNLIKLKLMDILQAPQEINQIGLVDSNLVFSFDVSADITVSINSVPSHVTKDMFYMILQSLCMLLLKLVNLSTQYHYVQRDILNEKQKCLDFLLISLRDLDGGSKVISQWAPENSKNYESLQQCTDDDIIKKLLHKGKFQHQEFLADSLKTLLSLRNKFQDVSRFEESGELNKKERVRFPAVNHFYNDDFELQADPTNEARPNSRGKIKPKTDFKPKSRESSTSSQLRLENFSESEATPEKTKSSSSLVEEYPQKKRKFGKVRIKN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
234AcetylationTLLSLRNKFQDVSRF
HHHHHHHHHHCHHHH		37.6625381059
244PhosphorylationDVSRFEESGELNKKE
CHHHHHHCCCCCHHH		30.3030377154
294PhosphorylationKTDFKPKSRESSTSS
CCCCCCCCCCCCCCC		50.2130377154
297PhosphorylationFKPKSRESSTSSQLR
CCCCCCCCCCCCHHH		37.4917101301
298PhosphorylationKPKSRESSTSSQLRL
CCCCCCCCCCCHHHH		27.7917101301
299PhosphorylationPKSRESSTSSQLRLE
CCCCCCCCCCHHHHH		41.5024961812
300PhosphorylationKSRESSTSSQLRLEN
CCCCCCCCCHHHHHC		20.3124961812
301PhosphorylationSRESSTSSQLRLENF
CCCCCCCCHHHHHCC		33.0723749301
309PhosphorylationQLRLENFSESEATPE
HHHHHCCCCCCCCCC		52.3625752575
311PhosphorylationRLENFSESEATPEKT
HHHCCCCCCCCCCCC		31.1921551504
314PhosphorylationNFSESEATPEKTKSS
CCCCCCCCCCCCCCC		28.1223749301
318PhosphorylationSEATPEKTKSSSSLV
CCCCCCCCCCCCHHH		34.2022369663
320PhosphorylationATPEKTKSSSSLVEE
CCCCCCCCCCHHHHH		40.4622369663
321PhosphorylationTPEKTKSSSSLVEEY
CCCCCCCCCHHHHHC		26.0422369663
322PhosphorylationPEKTKSSSSLVEEYP
CCCCCCCCHHHHHCH		34.4822369663
323PhosphorylationEKTKSSSSLVEEYPQ
CCCCCCCHHHHHCHH		38.0822369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NEJ1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NEJ1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NEJ1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LIF1_YEASTLIF1physical
11701889
CG21_YEASTCLB1genetic
17314980
SPT4_YEASTSPT4genetic
17314980
SP382_YEASTSPP382physical
17389648
LIF1_YEASTLIF1physical
17389648
LIF1_YEASTLIF1physical
17567543
NEJ1_YEASTNEJ1physical
17567543
DNLI4_YEASTDNL4physical
17567543
NEJ1_YEASTNEJ1physical
17765666
LIF1_YEASTLIF1physical
17765666
LIF1_YEASTLIF1physical
18458108
SRS2_YEASTSRS2physical
19571008
LIF1_YEASTLIF1physical
19571008
RAD51_YEASTRAD51genetic
19571008
KU70_YEASTYKU70physical
21149442
KU80_YEASTYKU80physical
21149442
PUF6_YEASTPUF6genetic
27708008
AIM11_YEASTAIM11genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
ENT4_YEASTENT4genetic
27708008
PABC_YEASTABZ2genetic
27708008
HDA1_YEASTHDA1genetic
27708008
SIW14_YEASTSIW14genetic
27708008
MKT1_YEASTMKT1genetic
27708008
ATX2_YEASTATX2genetic
27708008
KIN4_YEASTKIN4genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
GAL10_YEASTGAL10genetic
27708008
SPT2_YEASTSPT2genetic
27708008
PALF_YEASTRIM8genetic
27708008
STF2_YEASTSTF2genetic
27708008
RS27B_YEASTRPS27Bgenetic
27708008
STB5_YEASTSTB5genetic
27708008
ACA2_YEASTCST6genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
YJU6_YEASTYJL206Cgenetic
27708008
MOG1_YEASTMOG1genetic
27708008
HOC1_YEASTHOC1genetic
27708008
NNK1_YEASTNNK1genetic
27708008
TSR2_YEASTTSR2genetic
27708008
RSF1_YEASTRSF1genetic
27708008
SCS7_YEASTSCS7genetic
27708008
RCE1_YEASTRCE1genetic
27708008
DIA1_YEASTDIA1genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
YNL5_YEASTYNL115Cgenetic
27708008
PFD4_YEASTGIM3genetic
27708008
IRA2_YEASTIRA2genetic
27708008
KTR1_YEASTKTR1genetic
27708008
SERC_YEASTSER1genetic
27708008
FABD_YEASTMCT1genetic
27708008
YO338_YEASTYOR338Wgenetic
27708008
PDE2_YEASTPDE2genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
ATH1_YEASTATH1genetic
27708008
OPT2_YEASTOPT2genetic
27708008
LIF1_YEASTLIF1genetic
25942368
SGS1_YEASTSGS1genetic
28679532
RAD50_YEASTRAD50genetic
28679532
MRE11_YEASTMRE11genetic
28679532
EXO1_YEASTEXO1genetic
28679532
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NEJ1_YEAST

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory