LIF1_YEAST - dbPTM
LIF1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LIF1_YEAST
UniProt AC P53150
Protein Name Ligase-interacting factor 1
Gene Name LIF1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 421
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Stabilizes DNL4. Involved in non-homologous repair of DNA double-strand breaks..
Protein Sequence MSQLTEFISCIPVVNEEQNEEDERGLCKIQIEDGAMLETLDENSLSGLRIEKMLVSEGTGIFSKSSFGINDLRIFTGENIDEESKKYVWYELLKMLTGHKVYIASLDEKVVFTKWTCRMQDDEVWKVVMELESSAIIRKIAELTLHPVKKGEIDLFEMADKLYKDICCVNDSYRNIKESDSSNRNRVEQLARERELLDKLLETRDERTRAMMVTLLNEKKKKIRELHEILRQNNIKLSDDDVLDSALINTEVQKPISELNSPGKRMKRRKTVVEPQNLQKKLKDTSRRRANRKISNQSVIKMEDDDFDDFQFFGLSKRPIITAKDKLSEKYDDITSFGDDTQSISFESDSSSDVQKHLVSLEDNGIQISAGRSDEDYGDISGSESETDASAGEKKSSNHSEQSGNDREPCLQTESETDIET
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
105PhosphorylationGHKVYIASLDEKVVF
CCCEEEEECCCCEEE		27.1327214570
245PhosphorylationSDDDVLDSALINTEV
CCCHHHHHHHHCHHC		22.3324961812
250PhosphorylationLDSALINTEVQKPIS
HHHHHHCHHCCCCHH		30.4619779198
257PhosphorylationTEVQKPISELNSPGK
HHCCCCHHHCCCCCC		44.5520377248
261PhosphorylationKPISELNSPGKRMKR
CCHHHCCCCCCCHHH		47.8822369663
295PhosphorylationRRANRKISNQSVIKM
HHHHHHCCCCCCEEC		31.6727214570
316PhosphorylationDFQFFGLSKRPIITA
CCCCCCCCCCCEEEC		27.3121551504
324AcetylationKRPIITAKDKLSEKY
CCCEEECCHHHHHHC		46.9025381059
417PhosphorylationCLQTESETDIET---
CCCCCCCCCCCC---		52.1023749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LIF1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LIF1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LIF1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MEC3_YEASTMEC3physical
11805837
AHP1_YEASTAHP1physical
11805837
CSK22_YEASTCKA2physical
11805837
DNLI4_YEASTDNL4physical
11805837
DNLI4_YEASTDNL4physical
10679327
NEJ1_YEASTNEJ1physical
11711435
NEJ1_YEASTNEJ1physical
11676923
XRS2_YEASTXRS2physical
11741545
GPP2_YEASTGPP2physical
16554755
DNLI4_YEASTDNL4physical
16388993
SDC1_YEASTSDC1genetic
17314980
SAC3_YEASTSAC3genetic
17314980
SP382_YEASTSPP382physical
17389648
DNLI4_YEASTDNL4physical
17389648
NEJ1_YEASTNEJ1physical
17567543
DNLI4_YEASTDNL4physical
17567543
RV167_YEASTRVS167physical
18719252
DNLI4_YEASTDNL4physical
18719252
NEJ1_YEASTNEJ1physical
22563681
DNLI4_YEASTDNL4physical
22563681
XRS2_YEASTXRS2physical
22563681
DNLI4_YEASTDNL4physical
23571759
XRS2_YEASTXRS2physical
23571759
NEJ1_YEASTNEJ1physical
23571759
LIF1_YEASTLIF1physical
23571759
LCB2_YEASTLCB2genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
NU159_YEASTNUP159genetic
27708008
CDC11_YEASTCDC11genetic
27708008
MYO2_YEASTMYO2genetic
27708008
CALM_YEASTCMD1genetic
27708008
SUB2_YEASTSUB2genetic
27708008
UPPS_YEASTNUS1genetic
27708008
GLE1_YEASTGLE1genetic
27708008
TIM22_YEASTTIM22genetic
27708008
MAK21_YEASTMAK21genetic
27708008
STN1_YEASTSTN1genetic
27708008
TFB1_YEASTTFB1genetic
27708008
FCF1_YEASTFCF1genetic
27708008
RSP5_YEASTRSP5genetic
27708008
SMD1_YEASTSMD1genetic
27708008
STS1_YEASTSTS1genetic
27708008
CDC6_YEASTCDC6genetic
27708008
ERO1_YEASTERO1genetic
27708008
VTI1_YEASTVTI1genetic
27708008
SEC12_YEASTSEC12genetic
27708008
TYSY_YEASTCDC21genetic
27708008
DYR_YEASTDFR1genetic
27708008
TIM50_YEASTTIM50genetic
27708008
BUB1_YEASTBUB1genetic
27453043
YL422_YEASTYLR422Wgenetic
27453043
KIN28_YEASTKIN28genetic
27453043
CDC42_YEASTCDC42genetic
27453043
PHO85_YEASTPHO85genetic
27453043
ERG1_YEASTERG1genetic
27453043
IRA2_YEASTIRA2genetic
27453043
INO2_YEASTINO2genetic
27453043
VPS53_YEASTVPS53genetic
27453043
IME2_YEASTIME2genetic
27453043
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LIF1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261, AND MASSSPECTROMETRY.

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