ERG1_YEAST - dbPTM
ERG1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ERG1_YEAST
UniProt AC P32476
Protein Name Squalene monooxygenase
Gene Name ERG1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 496
Subcellular Localization Microsome membrane
Multi-pass membrane protein. Endoplasmic reticulum membrane
Multi-pass membrane protein.
Protein Description Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway..
Protein Sequence MSAVNVAPELINADNTITYDAIVIGAGVIGPCVATGLARKGKKVLIVERDWAMPDRIVGELMQPGGVRALRSLGMIQSINNIEAYPVTGYTVFFNGEQVDIPYPYKADIPKVEKLKDLVKDGNDKVLEDSTIHIKDYEDDERERGVAFVHGRFLNNLRNITAQEPNVTRVQGNCIEILKDEKNEVVGAKVDIDGRGKVEFKAHLTFICDGIFSRFRKELHPDHVPTVGSSFVGMSLFNAKNPAPMHGHVILGSDHMPILVYQISPEETRILCAYNSPKVPADIKSWMIKDVQPFIPKSLRPSFDEAVSQGKFRAMPNSYLPARQNDVTGMCVIGDALNMRHPLTGGGMTVGLHDVVLLIKKIGDLDFSDREKVLDELLDYHFERKSYDSVINVLSVALYSLFAADSDNLKALQKGCFKYFQRGGDCVNKPVEFLSGVLPKPLQLTRVFFAVAFYTIYLNMEERGFLGLPMALLEGIMILITAIRVFTPFLFGELIG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
40UbiquitinationVATGLARKGKKVLIV
HHHHHHCCCCEEEEE		70.2722817900
42UbiquitinationTGLARKGKKVLIVER
HHHHCCCCEEEEEEC		42.6222817900
43UbiquitinationGLARKGKKVLIVERD
HHHCCCCEEEEEECC		51.4422817900
106UbiquitinationVDIPYPYKADIPKVE
CCCCCCCCCCCCCHH		34.7717644757
111UbiquitinationPYKADIPKVEKLKDL
CCCCCCCCHHHHHHH		64.4617644757
114UbiquitinationADIPKVEKLKDLVKD
CCCCCHHHHHHHHHC		64.9217644757
116UbiquitinationIPKVEKLKDLVKDGN
CCCHHHHHHHHHCCC		61.1517644757
120UbiquitinationEKLKDLVKDGNDKVL
HHHHHHHHCCCCCCC		68.1817644757
125UbiquitinationLVKDGNDKVLEDSTI
HHHCCCCCCCCCCEE		53.3617644757
135AcetylationEDSTIHIKDYEDDER
CCCEEEEECCCCCHH		39.8424489116
135UbiquitinationEDSTIHIKDYEDDER
CCCEEEEECCCCCHH		39.8424961812
179AcetylationGNCIEILKDEKNEVV
CCEEEEEECCCCCEE		70.2924489116
179UbiquitinationGNCIEILKDEKNEVV
CCEEEEEECCCCCEE		70.2917644757
182UbiquitinationIEILKDEKNEVVGAK
EEEEECCCCCEEEEE		69.4217644757
182AcetylationIEILKDEKNEVVGAK
EEEEECCCCCEEEEE		69.4224489116
189UbiquitinationKNEVVGAKVDIDGRG
CCCEEEEEEECCCCC		34.2117644757
201UbiquitinationGRGKVEFKAHLTFIC
CCCCEEEEEEEEEEC		22.7617644757
217UbiquitinationGIFSRFRKELHPDHV
HHHHHHHHHHCCCCC		63.0117644757
240UbiquitinationGMSLFNAKNPAPMHG
CHHCCCCCCCCCCCC		65.6517644757
274PhosphorylationETRILCAYNSPKVPA
HCEEEEECCCCCCCC		18.3828889911
278UbiquitinationLCAYNSPKVPADIKS
EEECCCCCCCCCHHH		61.7523749301
284UbiquitinationPKVPADIKSWMIKDV
CCCCCCHHHHHHCCC		38.3223749301
289UbiquitinationDIKSWMIKDVQPFIP
CHHHHHHCCCCCCCC		35.4223749301
297AcetylationDVQPFIPKSLRPSFD
CCCCCCCHHHCCCHH		58.2524489116
297UbiquitinationDVQPFIPKSLRPSFD
CCCCCCCHHHCCCHH		58.2524961812
311UbiquitinationDEAVSQGKFRAMPNS
HHHHHCCCCCCCCCC		24.8423749301
311AcetylationDEAVSQGKFRAMPNS
HHHHHCCCCCCCCCC		24.8424489116
360UbiquitinationHDVVLLIKKIGDLDF
HHHHHHHHHHCCCCC		38.0023749301
361UbiquitinationDVVLLIKKIGDLDFS
HHHHHHHHHCCCCCH		44.9517644757
372UbiquitinationLDFSDREKVLDELLD
CCCHHHHHHHHHHHH		49.3322106047
385UbiquitinationLDYHFERKSYDSVIN
HHHHHHCCCHHHHHH		46.2817644757
410UbiquitinationAADSDNLKALQKGCF
HCCCCHHHHHHHHHH		53.9922817900
414UbiquitinationDNLKALQKGCFKYFQ
CHHHHHHHHHHHHHH		59.5023749301
418UbiquitinationALQKGCFKYFQRGGD
HHHHHHHHHHHCCCC		49.5923749301
418AcetylationALQKGCFKYFQRGGD
HHHHHHHHHHHCCCC		49.5924489116
429UbiquitinationRGGDCVNKPVEFLSG
CCCCCCCCCHHHHHC		30.0023749301
440UbiquitinationFLSGVLPKPLQLTRV
HHHCCCCCCHHHHHH		54.9523749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ERG1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ERG1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ERG1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ERG28_YEASTERG28physical
15995173
CP51_YEASTERG11genetic
14554200
YHI0_YEASTYHR020Wphysical
16429126
HSC82_YEASTHSC82physical
16429126
TOR1_YEASTTOR1genetic
16269340
YGB0_YEASTMPO1genetic
16269340
IRE1_YEASTIRE1genetic
16269340
MSMO_YEASTERG25physical
16300994
SC61G_YEASTSSS1physical
16093310
UBI4P_YEASTUBI4physical
20694217
ARGJ_YEASTARG7genetic
21623372
ACON2_YEASTACO2genetic
21623372
DHAS_YEASTHOM2genetic
21623372
INP53_YEASTINP53genetic
21623372
ATPO_YEASTATP5genetic
21623372
SYSM_YEASTDIA4genetic
21623372
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ERG1_YEAST

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Related Literatures of Post-Translational Modification
Ubiquitylation
ReferencePubMed
"A subset of membrane-associated proteins is ubiquitinated in responseto mutations in the endoplasmic reticulum degradation machinery.";
Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.;
Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-284, AND MASSSPECTROMETRY.
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-311, AND MASSSPECTROMETRY.

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