YBP1_YEAST - dbPTM
YBP1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YBP1_YEAST
UniProt AC P38315
Protein Name YAP1-binding protein 1
Gene Name YBP1 {ECO:0000303|PubMed:12743123}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 674
Subcellular Localization Cytoplasm .
Protein Description Involved in oxidative stress response and redox homeostasis. Required for hydrogen peroxide-induced oxidation and nuclear localization (activation) of YAP1. Functions probably in concert with HYP1/GPX3, the actual YAP1 modifying enzyme. YBP1 is not required for HYP1/GPX3-independent, diamide-induced oxidation of YAP1..
Protein Sequence MEPIDDILFEVTDAFKTQKEDLLELVTLIDIYGEQVNQEGSYEEKTRFIETLNTLLEDNPSTTGEIGWDLPKGLLKFLSKDNVDVNGRLGTNMIVQGVMKCFYAISIQGEPKKCLITGLELLSSLCSKDFSKSDQQNKEDFVDKKANTLPPEGVIENSSNRKDFPSYGESKSSNEFFLKLKSYILFEFIGASLKRISTLFPSKYLGAAVSTIEKFVYSHADTFEDALFLLRRVYTFCRNYIPPDPPKDIQLNEDFTREMFDKVVEEESELQVRLLRRLCTFGISTPIKTVTTNADVKYYCALNQQKFELSAYYTEYLELFCRYYQMAFSLDVDIEGEFQNVIKECRIIYKSVPQEISAVNDEAKLVLERMVYKLAYTFEVQKAAKEKNVGLDYNGVILFSGIHYLETNQHLVKEMNITDAIYLYLRFTTPSLYSKVYYNVAVESVSRYWLWYAITTEPLEDVKKELKNLSVFVTKTLLHVLLQKNCIQVNQQLRMITFTLLTRLLCLIPEKVAFEFILDVLKTSPLPLAKTSVLCVFKDLSRRRISTKDNDSETDLIVEKLSKLKVNDSNKAQQSNIRHYIQLDSSKMKAVHDCCLQTIQDSFTADAKKSDILLLLTYLNIFIVLKKTWDEDLLKIVCSKIDSNLKSVEPDKLPKYKEIVDKNESLNDYFTGIK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
76AcetylationDLPKGLLKFLSKDNV
CCCHHHHHHHCCCCC		49.6724489116
80AcetylationGLLKFLSKDNVDVNG
HHHHHHCCCCCCCCC		56.3124489116
112UbiquitinationISIQGEPKKCLITGL
HHCCCCCCEEEHHHH		52.3917644757
113UbiquitinationSIQGEPKKCLITGLE
HCCCCCCEEEHHHHH		45.0117644757
128UbiquitinationLLSSLCSKDFSKSDQ
HHHHHHCCCCCHHHH		62.8917644757
132UbiquitinationLCSKDFSKSDQQNKE
HHCCCCCHHHHCCHH		59.0317644757
138UbiquitinationSKSDQQNKEDFVDKK
CHHHHCCHHHHHCCC		55.0817644757
144UbiquitinationNKEDFVDKKANTLPP
CHHHHHCCCCCCCCC		48.7817644757
145UbiquitinationKEDFVDKKANTLPPE
HHHHHCCCCCCCCCC		42.2617644757
197PhosphorylationGASLKRISTLFPSKY
HHHHHHHHHHCCHHH		24.0826447709
198PhosphorylationASLKRISTLFPSKYL
HHHHHHHHHCCHHHH		30.0126447709
202PhosphorylationRISTLFPSKYLGAAV
HHHHHCCHHHHHHHH		26.9726447709
204PhosphorylationSTLFPSKYLGAAVST
HHHCCHHHHHHHHHH		18.0826447709
218PhosphorylationTIEKFVYSHADTFED
HHHHHHHHCCCCHHH		13.5927017623
284PhosphorylationRLCTFGISTPIKTVT
HHHHCCCCCCCEEEE		28.6327017623
538AcetylationTSVLCVFKDLSRRRI
HHEEEEECCCCCCCC		37.0424489116
548AcetylationSRRRISTKDNDSETD
CCCCCCCCCCCCCHH		47.9824489116
552PhosphorylationISTKDNDSETDLIVE
CCCCCCCCCHHHHHH		48.9621440633
554PhosphorylationTKDNDSETDLIVEKL
CCCCCCCHHHHHHHH		39.8024961812
560AcetylationETDLIVEKLSKLKVN
CHHHHHHHHHCCCCC		47.3624489116
669PhosphorylationKNESLNDYFTGIK--
CCCCHHHHHCCCC--		11.2819684113
671PhosphorylationESLNDYFTGIK----
CCHHHHHCCCC----		31.5919684113
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YBP1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YBP1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YBP1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AP1_YEASTYAP1physical
11805826
AP1_YEASTYAP1physical
12743123
AP1_YEASTYAP1physical
15075262
YBP2_YEASTYBP2genetic
15075262
AP1_YEASTYAP1physical
11283351
AP1_YEASTYAP1physical
18467557
SRS2_YEASTSRS2genetic
21459050
AP1_YEASTYAP1physical
21844193
AP1_YEASTYAP1physical
22615397
PRP19_YEASTPRP19genetic
27708008
THIK_YEASTPOT1genetic
27708008
PEX2_YEASTPEX2genetic
27708008
CUE2_YEASTCUE2genetic
27708008
MCR1_YEASTMCR1genetic
27708008
RS27A_YEASTRPS27Agenetic
27708008
ATG10_YEASTATG10genetic
27708008
MLH2_YEASTMLH2genetic
27708008
FRE8_YEASTFRE8genetic
27708008
UBX2_YEASTUBX2genetic
27708008
YM71_YEASTYMR226Cgenetic
27708008
NSE4_YEASTNSE4genetic
27708008
NSE3_YEASTNSE3genetic
27708008
ACT_YEASTACT1genetic
27708008
CDC20_YEASTCDC20genetic
27708008
COPB2_YEASTSEC27genetic
27708008
MPPA_YEASTMAS2genetic
27708008
CDC11_YEASTCDC11genetic
27708008
PRS7_YEASTRPT1genetic
27708008
BOS1_YEASTBOS1genetic
27708008
NEP1_YEASTEMG1genetic
27708008
UTP15_YEASTUTP15genetic
27708008
CLP1_YEASTCLP1genetic
27708008
GPI2_YEASTGPI2genetic
27708008
RV161_YEASTRVS161genetic
27708008
THRC_YEASTTHR4genetic
27708008
RLA3_YEASTRPP1Bgenetic
27708008
RAD57_YEASTRAD57genetic
27708008
YD286_YEASTYDR286Cgenetic
27708008
XRS2_YEASTXRS2genetic
27708008
RAD51_YEASTRAD51genetic
27708008
TNA1_YEASTTNA1genetic
27708008
YIT6_YEASTYIR016Wgenetic
27708008
ASF1_YEASTASF1genetic
27708008
PIR5_YEASTYJL160Cgenetic
27708008
YJ24_YEASTKCH1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
SRX1_YEASTSRX1genetic
27708008
DID2_YEASTDID2genetic
27708008
SRL3_YEASTSRL3genetic
27708008
RT109_YEASTRTT109genetic
27708008
UBR2_YEASTUBR2genetic
27708008
ERG3_YEASTERG3genetic
27708008
YL287_YEASTYLR287Cgenetic
27708008
TO6BL_YEASTREC102genetic
27708008
ROM2_YEASTROM2genetic
27708008
SST2_YEASTSST2genetic
27708008
ERG6_YEASTERG6genetic
27708008
UNG_YEASTUNG1genetic
27708008
TSA1_YEASTTSA1genetic
27708008
RCF1_YEASTRCF1genetic
27708008
RAD52_YEASTRAD52genetic
27708008
YMK8_YEASTYML108Wgenetic
27708008
AIM34_YEASTAIM34genetic
27708008
MTND_YEASTADI1genetic
27708008
MAC1_YEASTMAC1genetic
27708008
ARMT1_YEASTYMR027Wgenetic
27708008
STB2_YEASTSTB2genetic
27708008
GYL1_YEASTGYL1genetic
27708008
YM59_YEASTYMR209Cgenetic
27708008
MRE11_YEASTMRE11genetic
27708008
VAM10_YEASTVAM10genetic
27708008
RS10A_YEASTRPS10Agenetic
27708008
RMI1_YEASTRMI1genetic
27708008
PMA2_YEASTPMA2genetic
27708008
EF1G1_YEASTCAM1genetic
27708008
HUT1_YEASTHUT1genetic
27708008
AP1_YEASTYAP1physical
28628095
GPX3_YEASTHYR1physical
28628095
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YBP1_YEAST

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Related Literatures of Post-Translational Modification

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