dbPTM

NPP2_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NPP2_YEAST
UniProt AC	P39997
Protein Name	Ectonucleotide pyrophosphatase/phosphodiesterase 2
Gene Name	NPP2
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	493
Subcellular Localization	Membrane Single-pass type II membrane protein .
Protein Description	Mediates extracellular nucleotide derived phosphate hydrolysis along with NPP1 and PHO5..
Protein Sequence	MLLFEQPVDLEKNNEDDTNIKPFAISRHFLLKLLLCGIILIELLLYSKCPKPIDNGPRTIANRSNTYFNGTHDFKTLTILISIDGFHPRLIDAKYTPFLYNLHNLRSPYDMNITTAPYMIPSFPTQTFPNHWSMVTGKYPIEHGIVSNIFWDNFTSSEFRPNNLDARIWSNTADPIWQLLQTESQGEYKVATHMWPGSEVVYEDHGDVPRERMPFYFGKFNQWEKLQDKLAQIFRYIDMPQLKDRPELVISYIPNVDSYGHSFGYDLRDKRLQKLIGEVDGFFLDLIEGLQKRNLLKISNVMIVSDHGMSNVNANDGEHVVVWERVFPADAMSAFISHLYNEGPMMMVCLKNPRDKQWICDLIEAQLEKAYGDEISRKFHVILKEDFDPSWKYFQYDNRKHRYDDRVGDIWILADEYYAIVKEMGDVPIGIMGTHGYNFNNCSDMASIFIGMGPMFNNEVVPPFENIEVYNMLIKASALLGEEKTKKEKSLLQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	N-linked_Glycosylation	NGPRTIANRSNTYFN CCCCCCCCCCCCCCC	44.02	-
69	N-linked_Glycosylation	NRSNTYFNGTHDFKT CCCCCCCCCCCCCCE	44.00	-
112	N-linked_Glycosylation	LRSPYDMNITTAPYM CCCCCCCCCCCCCCC	26.09	-
153	N-linked_Glycosylation	VSNIFWDNFTSSEFR EEEEECCCCCCCCCC	32.46	-
441	N-linked_Glycosylation	THGYNFNNCSDMASI CCCCCCCCHHHHHHH	23.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NPP2_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NPP2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NPP2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HMT1_YEAST	HMT1	physical	16554755
UBP3_YEAST	UBP3	genetic	19269370
CTK3_YEAST	CTK3	genetic	19269370
MED5_YEAST	NUT1	genetic	20093466
RAD14_YEAST	RAD14	genetic	20093466
ZRC1_YEAST	ZRC1	genetic	20093466
NST1_YEAST	NST1	genetic	20093466
SFL1_YEAST	SFL1	genetic	20093466
MED1_YEAST	MED1	genetic	20093466
SHE1_YEAST	SHE1	genetic	27708008
MRM2_YEAST	MRM2	genetic	27708008
CTK1_YEAST	CTK1	genetic	27708008
PRP11_YEAST	PRP11	genetic	27708008
RPF1_YEAST	RPF1	genetic	27708008
BIG1_YEAST	BIG1	genetic	27708008
NU192_YEAST	NUP192	genetic	27708008
PRP21_YEAST	PRP21	genetic	27708008
MCM1_YEAST	MCM1	genetic	27708008
MOT1_YEAST	MOT1	genetic	27708008
ATC3_YEAST	DRS2	genetic	27708008
YBF9_YEAST	YBL059W	genetic	27708008
ECM8_YEAST	ECM8	genetic	27708008
RMD9L_YEAST	YBR238C	genetic	27708008
MTU1_YEAST	SLM3	genetic	27708008
RLA1_YEAST	RPP1A	genetic	27708008
CHO2_YEAST	CHO2	genetic	27708008
QCR9_YEAST	QCR9	genetic	27708008
PHB2_YEAST	PHB2	genetic	27708008
TBP7_YEAST	YTA7	genetic	27708008
SDS3_YEAST	SDS3	genetic	27708008
FLX1_YEAST	FLX1	genetic	27708008
COX12_YEAST	COX12	genetic	27708008
ASND1_YEAST	YML096W	genetic	27708008
MKS1_YEAST	MKS1	genetic	27708008
SWS2_YEAST	SWS2	genetic	27708008
ADE_YEAST	AAH1	genetic	27708008
RCF2_YEAST	RCF2	genetic	27708008
COQ10_YEAST	COQ10	genetic	27708008
COQ7_YEAST	CAT5	genetic	27708008
SPS4_YEAST	SPS4	genetic	27708008
MSC6_YEAST	MSC6	genetic	27708008
KAR3_YEAST	KAR3	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NPP2_YEAST

Related Literatures of Post-Translational Modification