YB085_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YB085_YEAST
• UniProt AC: O43137
• Protein Name: Uncharacterized protein YBR085C-A
• Gene Name: YBR085C-A
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 85
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Sequence: MSSALYKQSTNFTHSTGSFLQSAPVELTTVSGYQEFLKKQEKKNYEIQTVLSEDKSHGYVLKDGEVIANIIGEAKDYLLDLAGQA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	SSALYKQSTNFTHST CCHHCCCCCCCCCCC	22.59	22369663
10	Phosphorylation	SALYKQSTNFTHSTG CHHCCCCCCCCCCCC	31.68	22369663
13	Phosphorylation	YKQSTNFTHSTGSFL CCCCCCCCCCCCCCH	19.58	22369663
15	Phosphorylation	QSTNFTHSTGSFLQS CCCCCCCCCCCCHHC	31.26	22369663
16	Phosphorylation	STNFTHSTGSFLQSA CCCCCCCCCCCHHCC	29.28	22369663
18	Phosphorylation	NFTHSTGSFLQSAPV CCCCCCCCCHHCCCE	23.91	22369663
22	Phosphorylation	STGSFLQSAPVELTT CCCCCHHCCCEEEEE	36.37	22369663
28	Phosphorylation	QSAPVELTTVSGYQE HCCCEEEEECHHHHH	16.20	22369663
29	Phosphorylation	SAPVELTTVSGYQEF CCCEEEEECHHHHHH	25.87	22369663
31	Phosphorylation	PVELTTVSGYQEFLK CEEEEECHHHHHHHH	29.68	22369663
33	Phosphorylation	ELTTVSGYQEFLKKQ EEEECHHHHHHHHHH	9.43	22369663
45	Phosphorylation	KKQEKKNYEIQTVLS HHHHHCCCEEEEEEE	24.24	23749301
49	Phosphorylation	KKNYEIQTVLSEDKS HCCCEEEEEEECCCC	29.13	23749301
52	Phosphorylation	YEIQTVLSEDKSHGY CEEEEEEECCCCCCE	39.14	22369663
55	Ubiquitination	QTVLSEDKSHGYVLK EEEEECCCCCCEEEC	40.06	24961812
56	Phosphorylation	TVLSEDKSHGYVLKD EEEECCCCCCEEECC	34.17	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YB085_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YB085_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YB085_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDC20_YEAST	CDC20	genetic	27708008
SLI15_YEAST	SLI15	genetic	27708008
CDK1_YEAST	CDC28	genetic	27708008
MAK21_YEAST	MAK21	genetic	27708008
CDC1_YEAST	CDC1	genetic	27708008
CCA1_YEAST	CCA1	genetic	27708008
CDC11_YEAST	CDC11	genetic	27708008
FIP1_YEAST	FIP1	genetic	27708008
NEP1_YEAST	EMG1	genetic	27708008
SEC22_YEAST	SEC22	genetic	27708008
TAD3_YEAST	TAD3	genetic	27708008
PSB5_YEAST	PRE2	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; THR-16 AND SER-18,AND MASS SPECTROMETRY.
PubMed: 18407956

"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-10; THR-13; SER-15 ANDSER-18, AND MASS SPECTROMETRY.
PubMed: 17563356

"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-10, AND MASSSPECTROMETRY.
PubMed: 15665377