| UniProt ID | BPL1_YEAST | |
|---|---|---|
| UniProt AC | P48445 | |
| Protein Name | Biotin--protein ligase | |
| Gene Name | BPL1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 690 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase.. | |
| Protein Sequence | MNVLVYNGPGTTPGSVKHAVESLRDFLEPYYAVSTVNVKVLQTEPWMSKTSAVVFPGGADLPYVQACQPIISRLKHFVSKQGGVFIGFCAGGYFGTSRVEFAQGDPTMEVSGSRDLRFFPGTSRGPAYNGFQYNSEAGARAVKLNLPDGSQFSTYFNGGAVFVDADKFDNVEILATYAEHPDVPSSDSGKGQSENPAAVVLCTVGRGKVLLTGPHPEFNVRFMRKSTDKHFLETVVENLKAQEIMRLKFMRTVLTKTGLNCNNDFNYVRAPNLTPLFMASAPNKRNYLQEMENNLAHHGMHANNVELCSELNAETDSFQFYRGYRASYDAASSSLLHKEPDEVPKTVIFPGVDEDIPPFQYTPNFDMKEYFKYLNVQNTIGSLLLYGEVVTSTSTILNNNKSLLSSIPESTLLHVGTIQVSGRGRGGNTWINPKGVCASTAVVTMPLQSPVTNRNISVVFVQYLSMLAYCKAILSYAPGFSDIPVRIKWPNDLYALSPTYYKRKNLKLVNTGFEHTKLPLGDIEPAYLKISGLLVNTHFINNKYCLLLGCGINLTSDGPTTSLQTWIDILNEERQQLHLDLLPAIKAEKLQALYMNNLEVILKQFINYGAAEILPSYYELWLHSNQIVTLPDHGNTQAMITGITEDYGLLIAKELVSGSSTQFTGNVYNLQPDGNTFDIFKSLIAKKVQS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 186 | Phosphorylation | EHPDVPSSDSGKGQS CCCCCCCCCCCCCCC | 29.71 | 28889911 | |
| 193 | Phosphorylation | SDSGKGQSENPAAVV CCCCCCCCCCCCEEE | 48.27 | 19779198 | |
| 203 | Phosphorylation | PAAVVLCTVGRGKVL CCEEEEEEECCCEEE | 23.10 | 19779198 | |
| 229 | Acetylation | FMRKSTDKHFLETVV EEECCCCHHHHHHHH | 36.02 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BPL1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BPL1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BPL1_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ARC1_YEAST | ARC1 | physical | 15272000 | |
| RRP1_YEAST | RRP1 | physical | 16554755 | |
| SNU13_YEAST | SNU13 | physical | 16554755 | |
| CCZ1_YEAST | CCZ1 | genetic | 20093466 | |
| SWD3_YEAST | SWD3 | genetic | 20093466 | |
| MSH4_YEAST | MSH4 | genetic | 20093466 | |
| YIK2_YEAST | YIL102C | genetic | 20093466 | |
| YPT6_YEAST | YPT6 | genetic | 20093466 | |
| MSB4_YEAST | MSB4 | genetic | 20093466 | |
| DFG16_YEAST | DFG16 | genetic | 20093466 | |
| QCR10_YEAST | QCR10 | genetic | 21623372 | |
| PFKA1_YEAST | PFK1 | genetic | 21623372 | |
| THRC_YEAST | THR4 | genetic | 21623372 | |
| ATPF_YEAST | ATP4 | genetic | 21623372 | |
| ADH3_YEAST | ADH3 | genetic | 21623372 | |
| ADE_YEAST | AAH1 | genetic | 21623372 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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