| UniProt ID | EXO5_YEAST | |
|---|---|---|
| UniProt AC | P38289 | |
| Protein Name | Exonuclease V, mitochondrial | |
| Gene Name | EXO5 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 585 | |
| Subcellular Localization | Mitochondrion . | |
| Protein Description | Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively.. | |
| Protein Sequence | MLGRALINKYGFLIHPRRFVHLNDKSLDGTFILPSKKNHMYDVPTNDPSGILNASDIDRINNLPFFDNTSPTKETNTKEGALLSEKLASVKELFGEDPENPSFINYRFPRGLENPYFDIQVNQLKKKRLSVTQLCTTQNWCELRNFYDFYSQNLSNQLLNLKFQVQKGKKIHKSLEDETHPELNQYKSFTHNFLALTKLSMDIDNDMDALLDNWFNSINRLVSLFTKGDGHAREIVCHGFINLEDGKLVEHLLNSDSKTKENVIISGVIDHLTLRNRHNHQVQKGAAHLDTEYQSWGNILTNLLSNLKELKSNNEIVISDIKTRSVPKIPSIESVIESSKLQTMYYKFFFSHLSQDMTQTYHSFLINAQRRGLDVDAPINPTKILTFILTNPLFANDVKNLLYGLPINHSAFDNDAKGSNTFDMTAFNDLLDRGPTSFNVPIEQDEDSSESTKCVSLRDYGHFYTKWKTPLTLKYFAARLSQIYFIVGNLVSNDLMIEYYYHNDNFHNIIFPYDPLKLGTHAHDSAMVWFGGRDMHPIEPTQKNFNTYCKFCDYRHVCSWKNKNELKLIDLGKELKKIILESSMK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 312 | Phosphorylation | SNLKELKSNNEIVIS HCHHHHHHCCEEEEE | 58.47 | 27017623 | |
| 319 | Phosphorylation | SNNEIVISDIKTRSV HCCEEEEEECCCCCC | 23.53 | 27017623 | |
| 338 | Phosphorylation | SIESVIESSKLQTMY CHHHHHHHHCHHHHH | 22.96 | 22369663 | |
| 339 | Phosphorylation | IESVIESSKLQTMYY HHHHHHHHCHHHHHH | 25.29 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EXO5_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EXO5_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EXO5_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NSE4_YEAST | NSE4 | genetic | 27708008 | |
| TIM22_YEAST | TIM22 | genetic | 27708008 | |
| CCA1_YEAST | CCA1 | genetic | 27708008 | |
| ESP1_YEAST | ESP1 | genetic | 27708008 | |
| IPI1_YEAST | IPI1 | genetic | 27708008 | |
| CDC12_YEAST | CDC12 | genetic | 27708008 | |
| SLN1_YEAST | SLN1 | genetic | 27708008 | |
| TIM16_YEAST | PAM16 | genetic | 27708008 | |
| ARP3_YEAST | ARP3 | genetic | 27708008 | |
| CDC11_YEAST | CDC11 | genetic | 27708008 | |
| RSC4_YEAST | RSC4 | genetic | 27708008 | |
| SEC22_YEAST | SEC22 | genetic | 27708008 | |
| GSP1_YEAST | GSP1 | genetic | 27708008 | |
| LST8_YEAST | LST8 | genetic | 27708008 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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