dbPTM

LSB1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LSB1_YEAST
UniProt AC	P53281
Protein Name	LAS seventeen-binding protein 1
Gene Name	LSB1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	241
Subcellular Localization	Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, actin patch.
Protein Description	Involved in resistance to EDTA..
Protein Sequence	MSASLVNRSLKNIRNELEFLKESNVISGDIFELINSKLPEKWDGNQRSPQNADTEEYVEALYDFEAQQDGDLSLKTGDKIQVLEKISPDWYRGKSNNKIGIFPANYVKPAFTRSASPKSAEAASSSTVSRPSVPPPSYEPAASQYPSQQVSAPYAPPAGYMQAPPPQQQQAPLPYPPPFTNYYQQPQQQYAPPSQQAPVEAQPQQSSGASSAFKSFGSKLGNAAIFGAGSAIGSDIVNSIF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSASLVNRS ------CCHHHHHHH	26.94	22814378
2	Phosphorylation	------MSASLVNRS ------CCHHHHHHH	26.94	24961812
4	Phosphorylation	----MSASLVNRSLK ----CCHHHHHHHHH	26.08	24961812
11	Ubiquitination	SLVNRSLKNIRNELE HHHHHHHHHHHHHHH	52.13	17644757
21	Ubiquitination	RNELEFLKESNVISG HHHHHHHHHCCCCCH	65.50	17644757
37	Ubiquitination	IFELINSKLPEKWDG HHHHHHHCCCCCCCC	64.67	24961812
41	Ubiquitination	INSKLPEKWDGNQRS HHHCCCCCCCCCCCC	48.96	23749301
48	Phosphorylation	KWDGNQRSPQNADTE CCCCCCCCCCCCCHH	22.52	28889911
54	Phosphorylation	RSPQNADTEEYVEAL CCCCCCCHHHHHHHH	28.45	28132839
57	Phosphorylation	QNADTEEYVEALYDF CCCCHHHHHHHHHCH	9.43	21440633
75	Ubiquitination	QDGDLSLKTGDKIQV CCCCCCCCCCCEEEE	47.27	22817900
79	Ubiquitination	LSLKTGDKIQVLEKI CCCCCCCEEEEEEEC	36.06	23749301
87	Phosphorylation	IQVLEKISPDWYRGK EEEEEECCCCCCCCC	28.07	21440633
94	Ubiquitination	SPDWYRGKSNNKIGI CCCCCCCCCCCEEEE	40.80	22817900
98	Acetylation	YRGKSNNKIGIFPAN CCCCCCCEEEEEEHH	46.70	24489116
98	Ubiquitination	YRGKSNNKIGIFPAN CCCCCCCEEEEEEHH	46.70	22817900
106	Phosphorylation	IGIFPANYVKPAFTR EEEEEHHHCCCCCCC	16.38	22369663
108	Ubiquitination	IFPANYVKPAFTRSA EEEHHHCCCCCCCCC	21.92	17644757
108	Acetylation	IFPANYVKPAFTRSA EEEHHHCCCCCCCCC	21.92	24489116
112	Phosphorylation	NYVKPAFTRSASPKS HHCCCCCCCCCCHHH	26.31	22369663
114	Phosphorylation	VKPAFTRSASPKSAE CCCCCCCCCCHHHHH	30.00	19823750
116	Phosphorylation	PAFTRSASPKSAEAA CCCCCCCCHHHHHHH	33.82	19823750
118	Ubiquitination	FTRSASPKSAEAASS CCCCCCHHHHHHHCC	60.86	22106047
119	Phosphorylation	TRSASPKSAEAASSS CCCCCHHHHHHHCCC	34.42	28889911
124	Phosphorylation	PKSAEAASSSTVSRP HHHHHHHCCCCCCCC	31.69	28889911
219	Ubiquitination	AFKSFGSKLGNAAIF HHHHHHHHHHCHHHC	61.87	22106047

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RSP5	P39940	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LSB1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LSB1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LAS17_YEAST	LAS17	physical	11743162
APP1_YEAST	APP1	physical	11743162
SGF73_YEAST	SGF73	genetic	18931302
ACBP_YEAST	ACB1	physical	19841731
ENG2_YEAST	ACF2	physical	19841731
SYG2_YEAST	GRS2	physical	19841731
MCA1_YEAST	MCA1	physical	19841731
MET31_YEAST	MET31	physical	19841731
GYP3_YEAST	MSB3	physical	19841731
LAS17_YEAST	LAS17	physical	21777813
UBI4P_YEAST	UBI4	physical	21777813
ERF3_YEAST	SUP35	physical	21777813
ACT_YEAST	ACT1	physical	21777813
LAS17_YEAST	LAS17	physical	23577202
PIN3_YEAST	PIN3	physical	23577202
PIN3_YEAST	PIN3	genetic	25143386
PIN3_YEAST	PIN3	physical	25143386
GLE1_YEAST	GLE1	genetic	27708008
MOB1_YEAST	MOB1	genetic	27708008
SSL1_YEAST	SSL1	genetic	27708008
SEC22_YEAST	SEC22	genetic	27708008
IMB1_YEAST	KAP95	genetic	27708008
HAS1_YEAST	HAS1	genetic	27708008
PSB5_YEAST	PRE2	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LSB1_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48, AND MASSSPECTROMETRY.	18407956 [Abstract]
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114 AND SER-116, ANDMASS SPECTROMETRY.	17287358 [Abstract]
Ubiquitylation
Reference	PubMed
"A subset of membrane-associated proteins is ubiquitinated in responseto mutations in the endoplasmic reticulum degradation machinery."; Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.; Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-41 AND LYS-79, AND MASSSPECTROMETRY.	14557538 [Abstract]
"A proteomics approach to understanding protein ubiquitination."; Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.; Nat. Biotechnol. 21:921-926(2003). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-41 AND LYS-79, AND MASSSPECTROMETRY.	12872131 [Abstract]