PIN3_YEAST - dbPTM
PIN3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PIN3_YEAST
UniProt AC Q06449
Protein Name [PSI+] inducibility protein 3
Gene Name PIN3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 215
Subcellular Localization Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, actin patch . When overexpressed, localizes to punctate structures which are reminiscent of cortical actin patches (PubMed:21777813). Transiently colocalizes with SUP35 aggregates during prionogenesis (P
Protein Description Overproduction promotes the de novo induction of the [PSI+] prion form of SUP35. The prion-inducing effect depends on the association with the actin cytoskeleton. Also implicated in prion maintenance during heat stress..
Protein Sequence MSASLINRSLTNIRTELDFLKGSNVISNDVYDQINKSLPAKWDPANAPRNASPASLEYVEALYQFDPQQDGDLGLKPGDKVQLLEKLSPEWYKGSCNGRTGIFPANYVKPAFSGSNGPSNLPPPPQYKAQELQQIPTQNSAASSYQQQPFPPPSTNYYQQPQQQPQQAPPPQQQQQQQQHQSSHSHLKSFGSKLGNAAIFGAGASIGSDIVNNIF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSASLINRS
------CCHHHHHHH		26.9422814378
2Phosphorylation------MSASLINRS
------CCHHHHHHH		26.9422369663
4Phosphorylation----MSASLINRSLT
----CCHHHHHHHHC		23.6022369663
9PhosphorylationSASLINRSLTNIRTE
CHHHHHHHHCCHHHH		34.7522369663
11PhosphorylationSLINRSLTNIRTELD
HHHHHHHCCHHHHHH		29.8222369663
21UbiquitinationRTELDFLKGSNVISN
HHHHHHHCCCCCCCH		61.3517644757
36UbiquitinationDVYDQINKSLPAKWD
HHHHHHHHCCCCCCC		55.8123749301
41AcetylationINKSLPAKWDPANAP
HHHCCCCCCCCCCCC		50.6324489116
41UbiquitinationINKSLPAKWDPANAP
HHHCCCCCCCCCCCC		50.6323749301
52PhosphorylationANAPRNASPASLEYV
CCCCCCCCHHHHHHH		25.2522369663
55PhosphorylationPRNASPASLEYVEAL
CCCCCHHHHHHHHHH		25.7222369663
58PhosphorylationASPASLEYVEALYQF
CCHHHHHHHHHHHCC		14.6421440633
63PhosphorylationLEYVEALYQFDPQQD
HHHHHHHHCCCCCCC		17.7422369663
76UbiquitinationQDGDLGLKPGDKVQL
CCCCCCCCCCCHHHH		45.1923749301
80UbiquitinationLGLKPGDKVQLLEKL
CCCCCCCHHHHHHHH		37.4823749301
86AcetylationDKVQLLEKLSPEWYK
CHHHHHHHHCHHHHC		54.9924489116
88PhosphorylationVQLLEKLSPEWYKGS
HHHHHHHCHHHHCCC		31.6621440633
109UbiquitinationIFPANYVKPAFSGSN
EEEHHHCCCCCCCCC		21.9217644757
128UbiquitinationLPPPPQYKAQELQQI
CCCCCCCCHHHHHCC		38.0417644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PIN3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PIN3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PIN3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
APP1_YEASTAPP1physical
11743162
MCA1_YEASTMCA1physical
11743162
LAS17_YEASTLAS17physical
11743162
KPC1_YEASTPKC1physical
11743162
GYL1_YEASTGYL1physical
11743162
YIK8_YEASTYIL108Wphysical
11743162
GYP5_YEASTGYP5physical
11743162
PEX25_YEASTPEX25physical
11743162
FES1_YEASTFES1physical
11743162
UFD1_YEASTUFD1physical
11743162
UBI4P_YEASTUBI4physical
11743162
RL3_YEASTRPL3physical
11743162
PSA4_YEASTPRE6physical
11743162
MRD1_YEASTMRD1physical
11743162
MNN9_YEASTMNN9physical
11743162
MCR1_YEASTMCR1physical
11743162
HMDH2_YEASTHMG2physical
11743162
PABS_YEASTABZ1physical
11743162
PUR2_YEASTADE5,7physical
11743162
PIN3_YEASTPIN3physical
19345193
SGF73_YEASTSGF73genetic
18931302
SLX5_YEASTSLX5genetic
18931302
ENG2_YEASTACF2physical
19841731
APP1_YEASTAPP1physical
19841731
BSP1_YEASTBSP1physical
19841731
ATC8_YEASTDNF3physical
19841731
GIS1_YEASTGIS1physical
19841731
GYL1_YEASTGYL1physical
19841731
GYP5_YEASTGYP5physical
19841731
LAS17_YEASTLAS17physical
19841731
MCM6_YEASTMCM6physical
19841731
PSP1_YEASTPSP1physical
19841731
ULS1_YEASTULS1physical
19841731
RRP7_YEASTRRP7physical
19841731
SCM3_YEASTSCM3physical
19841731
SWC4_YEASTSWC4physical
19841731
THI21_YEASTTHI21physical
19841731
UBP7_YEASTUBP7physical
19841731
SYV_YEASTVAS1physical
19841731
VTC4_YEASTVTC4physical
19841731
YA063_YEASTYAL063C-Aphysical
19841731
AIM3_YEASTAIM3physical
19841731
YD159_YEASTYDL159W-Aphysical
19841731
YIK8_YEASTYIL108Wphysical
19841731
ZAP1_YEASTZAP1physical
19841731
2ABA_YEASTCDC55physical
19841731
SYG2_YEASTGRS2physical
19841731
MCA1_YEASTMCA1physical
19841731
MET31_YEASTMET31physical
19841731
UBI4P_YEASTUBI4physical
21777813
LAS17_YEASTLAS17physical
21777813
ERF3_YEASTSUP35physical
21777813
ACT_YEASTACT1physical
21777813
LAS17_YEASTLAS17physical
23577202
LSB1_YEASTLSB1physical
23577202
ERF3_YEASTSUP35physical
25143386
LSB1_YEASTLSB1physical
25143386
YGD9_YEASTYGL039Wgenetic
27708008
RTF1_YEASTRTF1genetic
27708008
YJ24_YEASTKCH1genetic
27708008
ARP6_YEASTARP6genetic
27708008
ATS1_YEASTATS1genetic
27708008
MYO4_YEASTMYO4genetic
27708008
YBQ6_YEASTYBR056Wgenetic
27708008
TBS1_YEASTTBS1genetic
27708008
AIM4_YEASTAIM4genetic
27708008
TXTP_YEASTCTP1genetic
27708008
GPR1_YEASTGPR1genetic
27708008
MCH1_YEASTMCH1genetic
27708008
ENT1_YEASTENT1genetic
27708008
NOP6_YEASTNOP6genetic
27708008
BRE4_YEASTBRE4genetic
27708008
PLP1_YEASTPLP1genetic
27708008
MSN5_YEASTMSN5genetic
27708008
CP56_YEASTDIT2genetic
27708008
POLH_YEASTRAD30genetic
27708008
YEW7_YEASTYER137Cgenetic
27708008
RAD24_YEASTRAD24genetic
27708008
DBP3_YEASTDBP3genetic
27708008
GPG1_YEASTGPG1genetic
27708008
YIP5_YEASTYIP5genetic
27708008
MDS3_YEASTMDS3genetic
27708008
TNA1_YEASTTNA1genetic
27708008
NAM8_YEASTNAM8genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
IME2_YEASTIME2genetic
27708008
CYP7_YEASTCPR7genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
RS27A_YEASTRPS27Agenetic
27708008
AIM29_YEASTAIM29genetic
27708008
NU133_YEASTNUP133genetic
27708008
MMP1_YEASTMMP1genetic
27708008
SWI6_YEASTSWI6genetic
27708008
CDA1_YEASTCDA1genetic
27708008
ROM2_YEASTROM2genetic
27708008
SST2_YEASTSST2genetic
27708008
U5071_YEASTYML003Wgenetic
27708008
CTK3_YEASTCTK3genetic
27708008
RSF1_YEASTRSF1genetic
27708008
SIW14_YEASTSIW14genetic
27708008
RNH2A_YEASTRNH201genetic
27708008
PFD4_YEASTGIM3genetic
27708008
INO4_YEASTINO4genetic
27708008
DNLI4_YEASTDNL4genetic
27708008
ISW2_YEASTISW2genetic
27708008
ALDH4_YEASTALD4genetic
27708008
HOS3_YEASTHOS3genetic
27708008
KA120_YEASTKAP120genetic
27708008
SPO19_YEASTSPO19genetic
27708008
ARPC5_YEASTARC15physical
23509072
ARPC3_YEASTARC18physical
23509072
LAS17_YEASTLAS17physical
23509072
SYTC_YEASTTHS1physical
23509072
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PIN3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52, AND MASSSPECTROMETRY.
Ubiquitylation
ReferencePubMed
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-80, AND MASSSPECTROMETRY.

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