ATC8_YEAST - dbPTM
ATC8_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATC8_YEAST
UniProt AC Q12674
Protein Name Probable phospholipid-transporting ATPase DNF3
Gene Name DNF3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1656
Subcellular Localization Golgi apparatus, trans-Golgi network membrane
Multi-pass membrane protein .
Protein Description This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable)..
Protein Sequence MGIADGQRRRSSSLRTQMFNKHLYDKYRGRTDDEIELEDINESKTFSGSDNNDKDDRDETSGNYAAEEDYEMEEYGSPDVSYSIITKILDTILDRRRTFHSKDGRHIPIILDHNAIEYKQAATKRDGHLIDERFNKPYCDNRITSSRYTFYSFLPRQLYAQFSKLANTYFFIVAVLQMIPGWSTTGTYTTIIPLCVFMGISMTREAWDDFRRHRLDKEENNKPVGVLVKDGNNDAQEVYTLPSSVVSSTAYLTKSAAAENNPPLNDDRNSSQGHFLDTHFNNFELLKNKYNVHIHQKKWEKLRVGDFVLLTQDDWVPADLLLLTCDGENSECFVETMALDGETNLKSKQPHPELNKLTKAASGLANINAQVTVEDPNIDLYNFEGNLELKNHRNDTIMKYPLGPDNVIYRGSILRNTQNVVGMVIFSGEETKIRMNALKNPRTKAPKLQRKINMIIVFMVFVVATISLFSYLGHVLHKKKYIDQNKAWYLFQADAGVAPTIMSFIIMYNTVIPLSLYVTMEIIKVVQSKMMEWDIDMYHAETNTPCESRTATILEELGQVSYIFSDKTGTLTDNKMIFRKFSLCGSSWLHNVDLGNSEDNFEDNRDNTNSLRLPPKAHNGSSIDVVSIGDQNVLDRLGFSDAPIEKGHRPSLDNFPKSRNSIEYKGNSSAIYTGRPSMRSLFGKDNSHLSKQASVISPSETFSENIKSSFDLIQFIQRYPTALFSQKAKFFFLSLALCHSCLPKKTHNESIGEDSIEYQSSSPDELALVTAARDLGYIVLNRNAQILTIKTFPDGFDGEAKLENYEILNYIDFNSQRKRMSVLVRMPNQPNQVLLICKGADNVIMERLHDRELAAKKMADICTSTKERKDAEAELVLQQRKSLERMVDEEAMARTSLRNSLSSVPRASLSLQAVRKSLSMKNSRTRDPEKQIDSIDQFLETVKKSDQEIGSVVNKSRKSLHKQQIEKYGPRISIDGTHFPNNNVPIDTRKEGLQHDYDTEILEHIGSDELILNEEYVIERTLQAIDEFSTEGLRTLVYAYKWIDIGQYENWNKRYHQAKTSLTDRKIKVDEAGAEIEDGLNLLGVTAIEDKLQDGVSEAIEKIRRAGIKMWMLTGDKRETAINIGYSCMLIKDYSTVVILTTTDENIISKMNAVSQEVDSGNIAHCVVVIDGATMAMFEGNPTYMSVFVELCTKTDSVICCRASPSQKALMVSNIRNTDPNLVTLAIGDGANDIAMIQSADIGVGIAGKEGLQASRVSDYSIGQFRFLLKLLFVHGRYNYIRTSKFMLCTFYKEITFYFTQLIYQRYTMFSGSSLYEPWSLSMFNTLFTSLPVLCIGMFEKDLKPMTLLTVPELYSYGRLSQGFNWLIFMEWVILATTNSLIITFLNVVMWGMSSLSDNTMYPLGLINFTAIVALINVKSQFVEMHNRNWLAFTSVVLSCGGWLVWCCALPILNNTDQIYDVAYGFYNHFGKDITFWCTSLVLALLPITLDIVYKTFKVMIWPSDSDIFAELEQKSDIRKKLELGAYSEMRQGWTWDKDPSTFTRYTDKVLSRPRTNSRASAKTHNSSIYSMSNGNVDHSSKKNFFGNSSKKSSERYEVLPSGKLIKRPSLKTQSSKDSIGGNITTKLTKKLKLPSRNVEDEDVNQIIQARLKDLE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationADGQRRRSSSLRTQM
CCCCCCCCHHHHHHH		23.5921440633
12PhosphorylationDGQRRRSSSLRTQMF
CCCCCCCHHHHHHHH		31.4219823750
13PhosphorylationGQRRRSSSLRTQMFN
CCCCCCHHHHHHHHH		24.1023749301
16PhosphorylationRRSSSLRTQMFNKHL
CCCHHHHHHHHHHHH		29.6719823750
31PhosphorylationYDKYRGRTDDEIELE
HHHHCCCCCCCEEHH		51.1030377154
43PhosphorylationELEDINESKTFSGSD
EHHHCCCCCCCCCCC		32.2928889911
47PhosphorylationINESKTFSGSDNNDK
CCCCCCCCCCCCCCC		42.4928889911
49PhosphorylationESKTFSGSDNNDKDD
CCCCCCCCCCCCCCC		35.6528889911
229UbiquitinationKPVGVLVKDGNNDAQ
CCCEEEEECCCCCCC		56.6117644757
243PhosphorylationQEVYTLPSSVVSSTA
CEEEECCHHHHCCHH		38.5921551504
244PhosphorylationEVYTLPSSVVSSTAY
EEEECCHHHHCCHHH		25.3021440633
247PhosphorylationTLPSSVVSSTAYLTK
ECCHHHHCCHHHHCH		21.5830377154
248PhosphorylationLPSSVVSSTAYLTKS
CCHHHHCCHHHHCHH		12.8721440633
249PhosphorylationPSSVVSSTAYLTKSA
CHHHHCCHHHHCHHH		16.3019779198
251PhosphorylationSVVSSTAYLTKSAAA
HHHCCHHHHCHHHHH		18.2627017623
254UbiquitinationSSTAYLTKSAAAENN
CCHHHHCHHHHHHCC		35.1917644757
270PhosphorylationPLNDDRNSSQGHFLD
CCCCCCCCCCCCCCC		25.5721440633
271PhosphorylationLNDDRNSSQGHFLDT
CCCCCCCCCCCCCCH		43.6721440633
347PhosphorylationDGETNLKSKQPHPEL
CCCCCCCCCCCCHHH		39.4219795423
542PhosphorylationIDMYHAETNTPCESR
CEEEECCCCCCCHHH		45.2121551504
552PhosphorylationPCESRTATILEELGQ
CCHHHHHHHHHHHCC		26.0221551504
561PhosphorylationLEELGQVSYIFSDKT
HHHHCCCEEEEECCC		12.4821551504
608PhosphorylationFEDNRDNTNSLRLPP
CCCCCCCCCCCCCCC		30.3928889911
621PhosphorylationPPKAHNGSSIDVVSI
CCCCCCCCCCEEEEE		29.4522369663
622PhosphorylationPKAHNGSSIDVVSIG
CCCCCCCCCEEEEEC		24.9822369663
627PhosphorylationGSSIDVVSIGDQNVL
CCCCEEEEECCCCHH		22.2422369663
646UbiquitinationFSDAPIEKGHRPSLD
CCCCCCCCCCCCCCC		61.8224961812
651PhosphorylationIEKGHRPSLDNFPKS
CCCCCCCCCCCCCCC		48.5919823750
661PhosphorylationNFPKSRNSIEYKGNS
CCCCCCCCEEECCCC		18.7123749301
668PhosphorylationSIEYKGNSSAIYTGR
CEEECCCCCEEECCC		29.8027017623
672PhosphorylationKGNSSAIYTGRPSMR
CCCCCEEECCCHHHH		11.6724961812
673PhosphorylationGNSSAIYTGRPSMRS
CCCCEEECCCHHHHH		22.1724961812
677PhosphorylationAIYTGRPSMRSLFGK
EEECCCHHHHHHHCC		26.0121440633
680PhosphorylationTGRPSMRSLFGKDNS
CCCHHHHHHHCCCCC		21.2921440633
690PhosphorylationGKDNSHLSKQASVIS
CCCCCCHHHHCEEEC		19.8028889911
694PhosphorylationSHLSKQASVISPSET
CCHHHHCEEECCCHH		19.9327717283
697PhosphorylationSKQASVISPSETFSE
HHHCEEECCCHHHHH		21.8820377248
699PhosphorylationQASVISPSETFSENI
HCEEECCCHHHHHHH		42.3425752575
701PhosphorylationSVISPSETFSENIKS
EEECCCHHHHHHHHH		36.4820377248
703PhosphorylationISPSETFSENIKSSF
ECCCHHHHHHHHHHH		36.8328889911
821PhosphorylationNSQRKRMSVLVRMPN
CCCCCEEEEEEECCC		19.1428889911
838UbiquitinationNQVLLICKGADNVIM
CEEEEEEECCCCCHH		50.5717644757
857UbiquitinationDRELAAKKMADICTS
CHHHHHHHHHHHHCC		34.3023749301
895PhosphorylationDEEAMARTSLRNSLS
CHHHHHHHHHHHHHH		23.6819779198
896PhosphorylationEEAMARTSLRNSLSS
HHHHHHHHHHHHHHC		21.5627017623
900PhosphorylationARTSLRNSLSSVPRA
HHHHHHHHHHCCCHH		24.1623749301
902PhosphorylationTSLRNSLSSVPRASL
HHHHHHHHCCCHHHH		29.1628889911
903PhosphorylationSLRNSLSSVPRASLS
HHHHHHHCCCHHHHH		41.2427017623
908PhosphorylationLSSVPRASLSLQAVR
HHCCCHHHHHHHHHH		21.5525704821
910PhosphorylationSVPRASLSLQAVRKS
CCCHHHHHHHHHHHH		18.8819779198
917PhosphorylationSLQAVRKSLSMKNSR
HHHHHHHHHCCCCCC		18.3423749301
919PhosphorylationQAVRKSLSMKNSRTR
HHHHHHHCCCCCCCC		34.5023749301
925PhosphorylationLSMKNSRTRDPEKQI
HCCCCCCCCCHHHHH		38.9628889911
945PhosphorylationFLETVKKSDQEIGSV
HHHHHHHHHHHHHHH		38.5221551504
951PhosphorylationKSDQEIGSVVNKSRK
HHHHHHHHHHHHHHH		28.6727017623
956PhosphorylationIGSVVNKSRKSLHKQ
HHHHHHHHHHHHHHH		39.4721551504
968PhosphorylationHKQQIEKYGPRISID
HHHHHHHHCCCEEEC		21.4121440633
973PhosphorylationEKYGPRISIDGTHFP
HHHCCCEEECCCCCC		18.8621440633
977PhosphorylationPRISIDGTHFPNNNV
CCEEECCCCCCCCCC		19.3224961812
1053UbiquitinationGQYENWNKRYHQAKT
HHHCCHHHHHHHHHC		46.0424961812
1136PhosphorylationMLIKDYSTVVILTTT
EEECCCCEEEEEEEC		16.7427017623
1141PhosphorylationYSTVVILTTTDENII
CCEEEEEEECCHHHH		19.2727017623
1142PhosphorylationSTVVILTTTDENIIS
CEEEEEEECCHHHHH		28.8927017623
1143PhosphorylationTVVILTTTDENIISK
EEEEEEECCHHHHHH		35.7627017623
1149PhosphorylationTTDENIISKMNAVSQ
ECCHHHHHHHHHHCC		23.2727017623
1208UbiquitinationCRASPSQKALMVSNI
EECCHHCCEEEEECC		48.0723749301
1316PhosphorylationMFSGSSLYEPWSLSM
CCCCCCCCCCCHHHH		23.1530377154
1320PhosphorylationSSLYEPWSLSMFNTL
CCCCCCCHHHHHHHH		22.6830377154
1322PhosphorylationLYEPWSLSMFNTLFT
CCCCCHHHHHHHHHH		18.8030377154
1538UbiquitinationRQGWTWDKDPSTFTR
CCCCCCCCCCCHHCC		64.2023749301
1556PhosphorylationKVLSRPRTNSRASAK
HHHCCCCCCCCCCCC		39.9821440633
1561PhosphorylationPRTNSRASAKTHNSS
CCCCCCCCCCCCCCC		29.2321440633
1564PhosphorylationNSRASAKTHNSSIYS
CCCCCCCCCCCCEEE		26.4627017623
1570PhosphorylationKTHNSSIYSMSNGNV
CCCCCCEEECCCCCC		10.5628889911
1573PhosphorylationNSSIYSMSNGNVDHS
CCCEEECCCCCCCCC		35.3328889911
1580PhosphorylationSNGNVDHSSKKNFFG
CCCCCCCCCCCCCCC		39.1128889911
1589PhosphorylationKKNFFGNSSKKSSER
CCCCCCCCCCCCCCC		43.8624961812
1590PhosphorylationKNFFGNSSKKSSERY
CCCCCCCCCCCCCCE		48.3721440633
1593PhosphorylationFGNSSKKSSERYEVL
CCCCCCCCCCCEEEC		40.9622369663
1594PhosphorylationGNSSKKSSERYEVLP
CCCCCCCCCCEEECC		34.6722369663
1597PhosphorylationSKKSSERYEVLPSGK
CCCCCCCEEECCCCC		13.3119823750
1602PhosphorylationERYEVLPSGKLIKRP
CCEEECCCCCCCCCC		44.3824961812
1613PhosphorylationIKRPSLKTQSSKDSI
CCCCCCCCCCCCCCC		38.6922369663
1615PhosphorylationRPSLKTQSSKDSIGG
CCCCCCCCCCCCCCC		44.5822369663
1616PhosphorylationPSLKTQSSKDSIGGN
CCCCCCCCCCCCCCC		30.5722369663
1619PhosphorylationKTQSSKDSIGGNITT
CCCCCCCCCCCCHHH		27.2022369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATC8_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATC8_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATC8_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATG15_YEASTATG15genetic
20093466
RLA4_YEASTRPP2Bgenetic
20093466
ELF1_YEASTELF1genetic
20093466
ROM2_YEASTROM2genetic
20093466
MSB4_YEASTMSB4genetic
20093466
ATC5_YEASTDNF1genetic
22308393
LEM3_YEASTLEM3physical
22791719
CRF1_YEASTCRF1physical
22791719
CDC50_YEASTCDC50physical
22791719
VPS27_YEASTVPS27genetic
23891562
PSD1_YEASTPSD1genetic
23891562
GET2_YEASTGET2genetic
23891562
ATC3_YEASTDRS2genetic
25378585
ATC4_YEASTDNF2genetic
25378585
CG11_YEASTCLN1genetic
25378585
CG13_YEASTCLN3genetic
25378585
PEX22_YEASTPEX22genetic
27708008
UBP13_YEASTUBP13genetic
27708008
CSG2_YEASTCSG2genetic
27708008
CCZ1_YEASTCCZ1genetic
27708008
MBA1_YEASTMBA1genetic
27708008
ATG15_YEASTATG15genetic
27708008
GPR1_YEASTGPR1genetic
27708008
SNF6_YEASTSNF6genetic
27708008
THIK_YEASTPOT1genetic
27708008
ROM2_YEASTROM2genetic
27708008
PET8_YEASTPET8genetic
27708008
PUB1_YEASTPUB1genetic
27708008
HDA1_YEASTHDA1genetic
27708008
SIW14_YEASTSIW14genetic
27708008
COX5A_YEASTCOX5Agenetic
27708008
ODP2_YEASTLAT1genetic
27708008
SWS2_YEASTSWS2genetic
27708008
MKT1_YEASTMKT1genetic
27708008
YNO4_YEASTYNL144Cgenetic
27708008
MSB4_YEASTMSB4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATC8_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-621; SER-622; SER-699AND SER-703, AND MASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-651, AND MASSSPECTROMETRY.

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