MMP1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MMP1_YEAST
• UniProt AC: Q12372
• Protein Name: S-methylmethionine permease 1
• Gene Name: MMP1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 583
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Endoplasmic reticulum .
• Protein Description: High-affinity S-methylmethionine (SMM) permease, required for utilization of S-methylmethionine as a sulfur source..
• Protein Sequence: MDEFESTKLSKVQFSTSVLSTPSNEGNNLIHRFKNSFKRNDSPAIQEGLLYSELSEEEKIQWDLANQPYKKVLDQRHLTMIAIGGTLGTGLFIGLGESLASGPASLLIGFLLVGASMLCVVQCGAELSCQYPVSGSYALHASRFIDPSVGFSIGINYLLMWLISYPSELVGCSLTISYWAPSVNPAAWVAIAFVLSMLLNLFGARGFAESEFYMSIFKIVALFIFIIIGIVLIAGGGPDSTGYIGTKYWHDPGSFAVPVFKNLCNTFVSAAYSFSGTEMVVLTSTEARSVSSVSRAAKGTFWRIIIFYIVTVIIIGCLVPYNDPRLISGSSSEDITASPFVIALSNTGAMGTRVSHFMNAVILIAVFSVCNSCVYASSRLIQGLATAGQLPKICAYMDRNGRPLVGMAICGAFGLLGFLVVSKNQGTVFTWLFALCSISFFTTWFCICFCQVRFRMAMKAQGRSKDDIIYRSTLGIYGGIFGCILNVLLVIGEIYVSAAPVGSPSSAANFFEYCMSIPIMIAVYIGHRIYRRDWRHWYIKRMDIDLDSGHSLEDFEATKLERDEDKKYVSSKPLYYRIYRFFC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MDEFESTKLSKVQ --CCHHHHCCCCEEE	35.84	30377154
7	Phosphorylation	-MDEFESTKLSKVQF -CCHHHHCCCCEEEE	28.89	30377154
8	Ubiquitination	MDEFESTKLSKVQFS CCHHHHCCCCEEEEE	61.10	24961812
11	Ubiquitination	FESTKLSKVQFSTSV HHHCCCCEEEEEECC	50.95	24961812
15	Phosphorylation	KLSKVQFSTSVLSTP CCCEEEEEECCCCCC	11.59	28889911
16	Phosphorylation	LSKVQFSTSVLSTPS CCEEEEEECCCCCCC	24.92	21440633
17	Phosphorylation	SKVQFSTSVLSTPSN CEEEEEECCCCCCCC	21.62	20377248
20	Phosphorylation	QFSTSVLSTPSNEGN EEEECCCCCCCCCCC	35.80	19684113
21	Phosphorylation	FSTSVLSTPSNEGNN EEECCCCCCCCCCCC	26.95	20377248
23	Phosphorylation	TSVLSTPSNEGNNLI ECCCCCCCCCCCCHH	47.83	25521595
42	Phosphorylation	NSFKRNDSPAIQEGL HCCCCCCCHHHHHCC	21.56	29734811
52	Phosphorylation	IQEGLLYSELSEEEK HHHCCCHHCCCHHHH	31.84	21551504
55	Phosphorylation	GLLYSELSEEEKIQW CCCHHCCCHHHHCCH	38.62	21551504

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MMP1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MMP1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MMP1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SHR3_YEAST	SHR3	physical	16093310
PHO88_YEAST	PHO88	physical	16093310
ALG1_YEAST	ALG1	physical	16093310
MKAR_YEAST	IFA38	physical	16093310
ELO2_YEAST	ELO2	physical	16093310
PMP3_YEAST	PMP3	physical	16093310
ALR2_YEAST	ALR2	physical	16093310
COAD_YEAST	CAB4	physical	16093310
ERV29_YEAST	ERV29	physical	16093310
SNL1_YEAST	SNL1	physical	16093310
YJQ3_YEAST	YJL163C	physical	16093310
YET1_YEAST	YET1	physical	16093310
ELO3_YEAST	ELO3	physical	16093310
GSF2_YEAST	GSF2	physical	16093310
YG5L_YEAST	YGR266W	genetic	20526336
YOR1_YEAST	YOR1	genetic	20526336
PDX3_YEAST	PDX3	genetic	21623372
SYSM_YEAST	DIA4	genetic	21623372
CND2_YEAST	BRN1	genetic	27708008
CDC1_YEAST	CDC1	genetic	27708008
MOB2_YEAST	MOB2	genetic	27708008
RRP41_YEAST	SKI6	genetic	27708008
MCM10_YEAST	MCM10	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.