HOS3_YEAST - dbPTM
HOS3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HOS3_YEAST
UniProt AC Q02959
Protein Name Histone deacetylase HOS3
Gene Name HOS3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 697
Subcellular Localization Nucleus.
Protein Description Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity)..
Protein Sequence MSSKHSDPLERFYKQFQAFVQNNPNVISAARAAAQIPESAKAVVVLSPYSLQHVFPREWVTKSYRKTIVERPERLLASSMGISAAITMYPSLFTLKSSHQRKGSLMAPHVLKVHGSSWPAELIELCQMADAKLLKGEIEVPDTWNSGDIYLSSKTIKALQGTIGAIETGVDSIFKGPSAEHISNRAFVAIRPPGHHCHYGTPSGFCLLNNAHVAIEYAYDTYNVTHVVVLDFDLHHGDGTQDICWKRAGFKPEEEPEDSSYDDFGKKFAEFPKVGYFSMHDINSFPTESGFATKENIKNASTCIMNSHDLNIWNIHLSKWTTEEEFNVLYRTKYRTLFAKADEFFRSAKLEMNQQGRPFKGLVVISAGFDASEFEQTSMQRHSVNVPTSFYTTFTKDALKLAQMHCHGKVLSLMEGGYSDKAICSGVFAHLIGLQNQDWVKEWGSEQVVKEIVRGCKPAWKPYKTKRAKDVIRIWAEEVIRLGRAMIPEFDDIIFKDAVNSAPSNSLLKATVEPASTSTIAQRIIRSHRSNASPEKELHENKPRSTEKQEQREIRSDTKVKQLSSNNRAAETQIPFLQQEFSSEDEDEEYVYDEELNKTFNRTVEDITIDDISRHLETLEIEKKGDEDSDHELKEKNWKNSHQRRLQGNGMYKIPSNTKPHRIRQPQNANTPTYDDSDISMISHVSRKHTTRSGGRW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
259PhosphorylationPEEEPEDSSYDDFGK
CCCCCCCCCCCCHHH		29.1820377248
260PhosphorylationEEEPEDSSYDDFGKK
CCCCCCCCCCCHHHH		44.9229136822
261PhosphorylationEEPEDSSYDDFGKKF
CCCCCCCCCCHHHHH		24.3920377248
276PhosphorylationAEFPKVGYFSMHDIN
HHCCCEEEEEHHCCC		8.7520377248
284PhosphorylationFSMHDINSFPTESGF
EEHHCCCCCCCCCCC		32.7020377248
293PhosphorylationPTESGFATKENIKNA
CCCCCCCCHHHHCCC		36.3120377248
332PhosphorylationEFNVLYRTKYRTLFA
HHHHHHHHCHHHHHH		20.9019779198
336PhosphorylationLYRTKYRTLFAKADE
HHHHCHHHHHHHHHH		24.1219779198
412PhosphorylationHCHGKVLSLMEGGYS
HHCCHHHHHHCCCCC		28.7619684113
501PhosphorylationIFKDAVNSAPSNSLL
EHHHHHHCCCCCCCC		34.6527214570
504PhosphorylationDAVNSAPSNSLLKAT
HHHHCCCCCCCCEEE		38.4727214570
506PhosphorylationVNSAPSNSLLKATVE
HHCCCCCCCCEEECC		39.1421551504
516PhosphorylationKATVEPASTSTIAQR
EEECCCCCHHHHHHH		33.3427214570
517PhosphorylationATVEPASTSTIAQRI
EECCCCCHHHHHHHH		31.8128889911
518PhosphorylationTVEPASTSTIAQRII
ECCCCCHHHHHHHHH		18.4721440633
533PhosphorylationRSHRSNASPEKELHE
HHHHCCCCHHHHHHC		37.5321082442
536AcetylationRSNASPEKELHENKP
HCCCCHHHHHHCCCC		69.8025381059
542AcetylationEKELHENKPRSTEKQ
HHHHHCCCCCCHHHH		38.5325381059
548AcetylationNKPRSTEKQEQREIR
CCCCCHHHHHHHHHH		60.2625381059
558PhosphorylationQREIRSDTKVKQLSS
HHHHHHHHHHHHHHH		38.7021551504
582PhosphorylationPFLQQEFSSEDEDEE
CHHHHHCCCCCCCCC		31.8721440633
583PhosphorylationFLQQEFSSEDEDEEY
HHHHHCCCCCCCCCE		55.1528152593
590PhosphorylationSEDEDEEYVYDEELN
CCCCCCCEECHHHHH		11.4019795423
592PhosphorylationDEDEEYVYDEELNKT
CCCCCEECHHHHHHH		19.4119779198
599PhosphorylationYDEELNKTFNRTVED
CHHHHHHHCCCCHHH		25.6821440633
603PhosphorylationLNKTFNRTVEDITID
HHHHCCCCHHHCCHH		29.3822369663
608PhosphorylationNRTVEDITIDDISRH
CCCHHHCCHHHHHHH		30.5822369663
613PhosphorylationDITIDDISRHLETLE
HCCHHHHHHHHHHEE		22.2028889911
623AcetylationLETLEIEKKGDEDSD
HHHEEHHHCCCCCCH		68.6522865919
629PhosphorylationEKKGDEDSDHELKEK
HHCCCCCCHHHHHHH		38.5325521595
656PhosphorylationNGMYKIPSNTKPHRI
CCCCCCCCCCCCCCC		61.6827017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HOS3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HOS3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HOS3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HOS3_YEASTHOS3physical
10535926
CDC31_YEASTCDC31physical
16554755
CSF1_YEASTCSF1genetic
17314980
NOT2_YEASTCDC36genetic
17314980
ELP3_YEASTELP3genetic
17314980
UBP3_YEASTUBP3genetic
17314980
SWC5_YEASTSWC5genetic
17314980
SWC3_YEASTSWC3genetic
17314980
RPA49_YEASTRPA49genetic
17314980
SWI4_YEASTSWI4genetic
17314980
HOS3_YEASTHOS3physical
18467557
AATC_YEASTAAT2genetic
18676811
BDF1_YEASTBDF1genetic
18676811
BEM3_YEASTBEM3genetic
18676811
ELP4_YEASTELP4genetic
18676811
ETR1_YEASTETR1genetic
18676811
INA17_YEASTINA17genetic
18676811
ISU1_YEASTISU1genetic
18676811
LTE1_YEASTLTE1genetic
18676811
PEX25_YEASTPEX25genetic
18676811
PML39_YEASTPML39genetic
18676811
RSC1_YEASTRSC1genetic
18676811
H3_YEASTHHT1physical
19379692
WHI5_YEASTWHI5physical
19823668
DPB3_YEASTDPB3genetic
20093466
KIP3_YEASTKIP3genetic
20093466
YM39_YEASTYMR166Cgenetic
20093466
RU2A_YEASTLEA1genetic
21245291
MSL1_YEASTMSL1genetic
21245291
HOS3_YEASTHOS3physical
22615397
KPC1_YEASTPKC1genetic
22579291
ODC1_YEASTODC1genetic
22579291
UGA2_YEASTUGA2genetic
22579291
NCA3_YEASTNCA3genetic
22579291
FOL1_YEASTFOL1genetic
22579291
EIF3A_YEASTRPG1genetic
22579291
GLRX7_YEASTGRX7genetic
22579291
PP2C7_YEASTPTC7genetic
22579291
HSL7_YEASTHSL7physical
25057019
YEL1_YEASTYEL1genetic
27708008
PYC2_YEASTPYC2genetic
27708008
PRM9_YEASTPRM9genetic
27708008
PDR3_YEASTPDR3genetic
27708008
RL19A_YEASTRPL19Bgenetic
27708008
RL19B_YEASTRPL19Bgenetic
27708008
CSG2_YEASTCSG2genetic
27708008
GPR1_YEASTGPR1genetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
BMH1_YEASTBMH1genetic
27708008
KIP3_YEASTKIP3genetic
27708008
RTG2_YEASTRTG2genetic
27708008
TOS2_YEASTTOS2genetic
27708008
METW_YEASTYLL058Wgenetic
27708008
SWI6_YEASTSWI6genetic
27708008
COA4_YEASTCOA4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HOS3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-533 AND SER-629, ANDMASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-629, AND MASSSPECTROMETRY.

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