METW_YEAST - dbPTM
METW_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID METW_YEAST
UniProt AC Q12198
Protein Name Putative cystathionine gamma-synthase YLL058W
Gene Name YLL058W
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 575
Subcellular Localization
Protein Description Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia (By similarity)..
Protein Sequence MTEIEFGQPLPSNLDYAVSFGIPTWDSAIGYAEKVPEVIGKMATGYPRYFPQPPVQRLCAYFVKKFGRGSENCRPFPSVNLGLKCFEYVKSVSGPESKAHLEVETVTIKNRGAKTSKEPAELVLTIAAVLASEEEFETVKEYWKLRGECVSSRLALSVNQLLDCANHGSEQVLRELEAGVFAAKKGEEKAKNLIKGRIVENRFRPFGLEKKTPNWEGLNLNPNEDVYLVSSGMSAISTARNLLTFWEEKKNSGDSLNKTTSDQKKKPLLCDTVGIFGFPFKDTQVIMTKFGKCKFFGFGNSRDVVELQKFLETSKQRILAVFVETPSNPLLNMPDLKKLRSLADQYGFFIVIDDTIGGLNVDILPYADIVSTSLTKLFNGASNVMGGSVVLNPKSSLYPYAREYFRSANFEDLLWCEDAIVLERNSRDFEDRTLRANANTGILLNDLLLPEEGKICKKIYYPTVTSKETFENYESVRNERGGYGCLFSVAFFNEGDAKAFYDSLKVFKGPSNGTNFTLACPYVHLAHHSELEEVSKFGADPNIIRVSVGLEDIQWLLKVFSSALDVVKSRGSKHS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
31PhosphorylationTWDSAIGYAEKVPEV
CHHHHHHHHHHHHHH		12.8928132839
376N6-(pyridoxal phosphate)lysineIVSTSLTKLFNGASN
HHHHHHHHHHCCCCC		57.27-
376OtherIVSTSLTKLFNGASN
HHHHHHHHHHCCCCC		57.27-
517PhosphorylationPSNGTNFTLACPYVH
CCCCCCEEEECCCHH		18.6029688323
522PhosphorylationNFTLACPYVHLAHHS
CEEEECCCHHHHCHH		10.6129688323
529PhosphorylationYVHLAHHSELEEVSK
CHHHHCHHHHHHHHH		33.7329688323
535PhosphorylationHSELEEVSKFGADPN
HHHHHHHHHHCCCCC		26.0829688323
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of METW_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of METW_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of METW_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TREB_YEASTNTH2genetic
20093466
ADPP_YEASTYSA1genetic
20093466
MED20_YEASTSRB2genetic
20093466
FIS1_YEASTFIS1genetic
20093466
MMS22_YEASTMMS22genetic
20093466
SSO2_YEASTSSO2genetic
20093466
ADE_YEASTAAH1genetic
20093466
MKS1_YEASTMKS1genetic
20093466
RTG1_YEASTRTG1genetic
20093466
NEW1_YEASTNEW1genetic
20093466
MRX11_YEASTYPL041Cgenetic
20093466
HSP72_YEASTSSA2physical
22940862
METW_YEASTYLL058Wphysical
22940862
ADPP_YEASTYSA1genetic
27708008
MED20_YEASTSRB2genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
AIM34_YEASTAIM34genetic
27708008
SSO2_YEASTSSO2genetic
27708008
SCS7_YEASTSCS7genetic
27708008
MKS1_YEASTMKS1genetic
27708008
RTG1_YEASTRTG1genetic
27708008
MRX11_YEASTYPL041Cgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of METW_YEAST

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Related Literatures of Post-Translational Modification

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