PEX25_YEAST - dbPTM
PEX25_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PEX25_YEAST
UniProt AC Q02969
Protein Name Peroxisomal membrane protein PEX25
Gene Name PEX25
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 394
Subcellular Localization Peroxisome membrane
Single-pass membrane protein .
Protein Description Required for regulation of peroxisome size and maintenance. Has a role in the import of peroxisomal matrix proteins. Imports RHO1 into the peroxisome. Also promotes peroxisome division and biogenesis..
Protein Sequence MSQFGTTDIVSGSETPPYSGASYQDAQDDNTHPHSSDAGAEKFSAGSGSESHTESSRSDDEDSQAKTKMVDNITILKYILDSLSGRDKLAKIIKYALDILKLFIEKSKRNLTVLDPSVLTYYTKILKNLTVKVALRHPITVIKVLLLSLLRNFDKKIDFISQQLSTFRYILRFGGTPFRVCSFLGKFNKTRKCNFQIDQIKKIWFNEASLREFLDLYYGIFDELDLLYKLKIWTNKSFYSFVSRQESLAWQYDILLSLKDHWLNLQSLQKRQLELEVQLKVQNNALLLSPILMHQAHKDDGSQSPIRKQLLNDLNVNNDAEVLIHKQLKAIKDEKTLVYLDIARLSFDCMANTSDILNLKTPKGTYAVLSLGSGLTGLVKLWITTKRSLCSSKD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSQFGTTDI
------CCCCCCCCC		33.9319823750
6Phosphorylation--MSQFGTTDIVSGS
--CCCCCCCCCCCCC		23.6819823750
7Phosphorylation-MSQFGTTDIVSGSE
-CCCCCCCCCCCCCC		24.9019823750
11PhosphorylationFGTTDIVSGSETPPY
CCCCCCCCCCCCCCC		36.6119823750
13PhosphorylationTTDIVSGSETPPYSG
CCCCCCCCCCCCCCC		30.6919823750
15PhosphorylationDIVSGSETPPYSGAS
CCCCCCCCCCCCCCC		31.1219823750
18PhosphorylationSGSETPPYSGASYQD
CCCCCCCCCCCCCCC		22.4219823750
19PhosphorylationGSETPPYSGASYQDA
CCCCCCCCCCCCCCC		33.3919823750
22PhosphorylationTPPYSGASYQDAQDD
CCCCCCCCCCCCCCC		27.1819823750
23PhosphorylationPPYSGASYQDAQDDN
CCCCCCCCCCCCCCC		15.1819823750
44PhosphorylationDAGAEKFSAGSGSES
HHCCCCCCCCCCCCC		42.6722890988
47PhosphorylationAEKFSAGSGSESHTE
CCCCCCCCCCCCCCC		38.5722890988
49PhosphorylationKFSAGSGSESHTESS
CCCCCCCCCCCCCCC		37.3122890988
51PhosphorylationSAGSGSESHTESSRS
CCCCCCCCCCCCCCC		37.0922890988
53PhosphorylationGSGSESHTESSRSDD
CCCCCCCCCCCCCCC		47.0122890988
55PhosphorylationGSESHTESSRSDDED
CCCCCCCCCCCCCCC		32.0122890988
56PhosphorylationSESHTESSRSDDEDS
CCCCCCCCCCCCCCH		29.5722890988
58PhosphorylationSHTESSRSDDEDSQA
CCCCCCCCCCCCHHH		51.8919823750
63PhosphorylationSRSDDEDSQAKTKMV
CCCCCCCHHHHHHHC		29.9519823750
107PhosphorylationLKLFIEKSKRNLTVL
HHHHHHHHCCCCEEC		24.8629688323
112PhosphorylationEKSKRNLTVLDPSVL
HHHCCCCEECCHHHH		23.6729688323
117PhosphorylationNLTVLDPSVLTYYTK
CCEECCHHHHHHHHH		29.4429688323
120PhosphorylationVLDPSVLTYYTKILK
ECCHHHHHHHHHHHH		16.6029688323
122PhosphorylationDPSVLTYYTKILKNL
CHHHHHHHHHHHHCC		9.0529688323
123PhosphorylationPSVLTYYTKILKNLT
HHHHHHHHHHHHCCC		10.9529688323
130PhosphorylationTKILKNLTVKVALRH
HHHHHCCCHHHHHCC		27.8921440633
289PhosphorylationQNNALLLSPILMHQA
HCCHHHHHHHHHHHH		15.1817330950
302PhosphorylationQAHKDDGSQSPIRKQ
HHHCCCCCCCHHHHH		34.1821440633
304PhosphorylationHKDDGSQSPIRKQLL
HCCCCCCCHHHHHHH		24.8025521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PEX25_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PEX25_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PEX25_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PEX25_YEASTPEX25physical
14517321
PEX27_YEASTPEX27physical
14517321
PEX19_YEASTPEX19physical
15133130
PEX27_YEASTPEX27genetic
14517338
PEX25_YEASTPEX25physical
18467557
DNM1L_HUMANDNM1Lgenetic
20826455
FIS1_HUMANFIS1genetic
20826455
PEX27_YEASTPEX27genetic
21951626
PEX14_YEASTPEX14physical
22375831
CTK1_YEASTCTK1genetic
27708008
PEX13_YEASTPEX13genetic
27708008
KPC1_YEASTPKC1genetic
27708008
APC11_YEASTAPC11genetic
27708008
ACT_YEASTACT1genetic
27708008
STT3_YEASTSTT3genetic
27708008
MPPA_YEASTMAS2genetic
27708008
MOB1_YEASTMOB1genetic
27708008
EXO70_YEASTEXO70genetic
27708008
SMC4_YEASTSMC4genetic
27708008
NOP2_YEASTNOP2genetic
27708008
CAP_YEASTSRV2genetic
27708008
ETR1_YEASTETR1genetic
27708008
ODPB_YEASTPDB1genetic
27708008
BAP3_YEASTBAP3genetic
27708008
CEM1_YEASTCEM1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
PFD3_YEASTPAC10genetic
27708008
TNA1_YEASTTNA1genetic
27708008
SODM_YEASTSOD2genetic
27708008
HTD2_YEASTHTD2genetic
27708008
IF4A_YEASTTIF2genetic
27708008
ELM1_YEASTELM1genetic
27708008
FABG_YEASTOAR1genetic
27708008
LIPB_YEASTLIP2genetic
27708008
DIA2_YEASTDIA2genetic
27708008
LIPA_YEASTLIP5genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PEX25_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289 AND SER-304, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-304, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58; SER-63 AND SER-304,AND MASS SPECTROMETRY.

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