YIK8_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YIK8_YEAST
• UniProt AC: P40483
• Protein Name: Putative zinc metalloproteinase YIL108W
• Gene Name: YIL108W
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 696
• Subcellular Localization: Cytoplasm .
• Protein Sequence: MVGSKDIDLFNLRENEQIVSPCLIVHGKCNKQNGAKTVQVQHPQLPPITYPIHNQFFKATVILTPGENKLTFVTDTNTARTIVCYYTPLTQNPPVHLCLILAKDSPLQFDSPREQKDREGGNGLELAIKKLRLGARLMQAYTNEQMLRNSMGNRTFPFVEEFTWDTLFERPAMRNTIKIHVVRSEKTVKEIQDPDIAQQNSKGKNTGALFGIAMDALKSYGGPFTNNEKPVQAACMFLDTHWDGKLIRGHAALGGGDDSIKLAIFGSHGLYSWPTCLEQLVPYFTDETRSSTSEVANDCNECGTYWECLTITLGAFMHEIGHLLGCPHQESGVMLRGYTTLNRSFLTKEAYSVRTNSTGASPPIFPKEECTWNRLDTVRFLYHPSFTLPQDYYDPSFMRPTKLGGYPNIKHSVYPLGNGSCRILSPTGIYLIEIICDDLARGHIEYLPVSLGGQGPQREVIVTLDDLRARLPKNELAKFGNTFKLKILSVNAPETEFDKFPSLLDVQPLDMSKYGFSKNVQGIKSPLYGRSDGGNAVGVVAFDVRLVTAVRIYHGYALDGVRFYYKEKPTGTKDAPASKPSVPPRNYFSKITHSIKNHASINEENLKSVLFGHETQNFTDATLEPGEIIIGFNLRCGAWVDAIQIITSHGRMTDMFGNKDGGGFAELQPPNGQYILGVTGRVGQWVDAFGIIYGAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MVGSKDIDLFNL ---CCCCCCCCCCCC	53.42	24961812
28	Ubiquitination	PCLIVHGKCNKQNGA CEEEEECEECCCCCC	21.54	17644757
36	Ubiquitination	CNKQNGAKTVQVQHP ECCCCCCEEEEEECC	51.10	17644757
58	Ubiquitination	PIHNQFFKATVILTP CCCCCEEEEEEEECC	44.42	17644757
64	Phosphorylation	FKATVILTPGENKLT EEEEEEECCCCCCEE	20.37	21440633
69	Ubiquitination	ILTPGENKLTFVTDT EECCCCCCEEEEECC	44.60	17644757
111	Phosphorylation	DSPLQFDSPREQKDR CCCCCCCCHHHHHCC	27.43	27214570
189	Ubiquitination	VRSEKTVKEIQDPDI EECCCCHHHHCCHHH	55.09	23749301
202	Ubiquitination	DIAQQNSKGKNTGAL HHHHHHCCCCCHHHH	79.88	23749301
204	Ubiquitination	AQQNSKGKNTGALFG HHHHCCCCCHHHHHH	55.88	17644757
218	Ubiquitination	GIAMDALKSYGGPFT HHHHHHHHHCCCCCC	43.27	17644757
229	Ubiquitination	GPFTNNEKPVQAACM CCCCCCCCCCCCCEE	53.24	17644757
245	Ubiquitination	LDTHWDGKLIRGHAA CCCCCCCCEECCCCC	37.96	23749301
261	Ubiquitination	GGGDDSIKLAIFGSH CCCCCCEEEEEECCC	35.50	17644757
344	Phosphorylation	GYTTLNRSFLTKEAY CEEEECHHHCCCEEE	24.43	27017623
348	Acetylation	LNRSFLTKEAYSVRT ECHHHCCCEEEEEEC	42.36	24489116
355	Phosphorylation	KEAYSVRTNSTGASP CEEEEEECCCCCCCC	31.22	21126336
357	Phosphorylation	AYSVRTNSTGASPPI EEEEECCCCCCCCCC	27.83	22369663
358	Phosphorylation	YSVRTNSTGASPPIF EEEECCCCCCCCCCC	38.55	22369663
361	Phosphorylation	RTNSTGASPPIFPKE ECCCCCCCCCCCCCH	32.33	22369663
385	Phosphorylation	VRFLYHPSFTLPQDY CCEEECCCCCCCHHH	19.97	28889911
392	Phosphorylation	SFTLPQDYYDPSFMR CCCCCHHHCCHHHCC	12.43	28889911
393	Phosphorylation	FTLPQDYYDPSFMRP CCCCHHHCCHHHCCC	29.66	28889911
402	Ubiquitination	PSFMRPTKLGGYPNI HHHCCCCCCCCCCCC	48.06	17644757
410	Ubiquitination	LGGYPNIKHSVYPLG CCCCCCCCCCEEECC	36.15	17644757
473	Ubiquitination	DLRARLPKNELAKFG HHHHHCCHHHHHHCC	68.59	23749301
478	Acetylation	LPKNELAKFGNTFKL CCHHHHHHCCCEEEE	67.44	24489116
478	Ubiquitination	LPKNELAKFGNTFKL CCHHHHHHCCCEEEE	67.44	23749301
486	Ubiquitination	FGNTFKLKILSVNAP CCCEEEEEEEEECCC	42.04	17644757
499	Ubiquitination	APETEFDKFPSLLDV CCCCCHHCCCCCCCC	65.58	17644757
513	Ubiquitination	VQPLDMSKYGFSKNV CCCCCHHHCCCCCCC	42.63	22817900
518	Acetylation	MSKYGFSKNVQGIKS HHHCCCCCCCCCCCC	59.90	24489116
518	Ubiquitination	MSKYGFSKNVQGIKS HHHCCCCCCCCCCCC	59.90	23749301
524	Ubiquitination	SKNVQGIKSPLYGRS CCCCCCCCCCCCCCC	53.50	23749301
566	Ubiquitination	DGVRFYYKEKPTGTK CCEEEEEEECCCCCC	48.13	22817900
568	Ubiquitination	VRFYYKEKPTGTKDA EEEEEEECCCCCCCC	43.67	23749301
573	Ubiquitination	KEKPTGTKDAPASKP EECCCCCCCCCCCCC	53.92	23749301
579	Ubiquitination	TKDAPASKPSVPPRN CCCCCCCCCCCCCCH	43.34	23749301
590	Ubiquitination	PPRNYFSKITHSIKN CCCHHHHHHHHHHHC	41.55	23749301
590	Acetylation	PPRNYFSKITHSIKN CCCHHHHHHHHHHHC	41.55	24489116
596	Ubiquitination	SKITHSIKNHASINE HHHHHHHHCCCCCCH	45.77	23749301
600	Phosphorylation	HSIKNHASINEENLK HHHHCCCCCCHHHHH	20.56	21551504
607	Ubiquitination	SINEENLKSVLFGHE CCCHHHHHHHHHCCC	50.53	17644757
659	Ubiquitination	MTDMFGNKDGGGFAE EEECCCCCCCCCCEE	59.12	17644757

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YIK8_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YIK8_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YIK8_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SEC65_YEAST	SEC65	physical	16554755
RTC4_YEAST	RTC4	physical	16554755

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361, AND MASSSPECTROMETRY.
PubMed: 18407956