| UniProt ID | RTC4_YEAST | |
|---|---|---|
| UniProt AC | P53850 | |
| Protein Name | Restriction of telomere capping protein 4 | |
| Gene Name | RTC4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 401 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | May be involved in a process influencing telomere capping.. | |
| Protein Sequence | MVGPGLGINRVRRKGVYSTKKGSGDNLLLMKRQGKHDIHDRESDDLSGHDAFSPSKKRGKIDSITEDEIEVKKLSTVATFDKLSRSFPNSEVQAAKNAALRGKEKEEEKVVSIPLIQNLKNEDIESIKCRNNNLLDGKKLLLEAELSAVEDNQIFSSSFPEDKKLSLQSCLSSKEQIIKKLQVREEYMSKFKLPPMLFSDELLTEVEPFMPIVMDILEGKISSVYYFEAKNAFKNSQKAYLSVDEFRKLNLNKFTAGFYGLKRQLRVGEEIAKRYKRALTHNQPATLKWWGITDFCNYVLAPETLTSFCIYQLNLSNKSCSSKTPNKHPKQQLNEKEYYYDPELRMLAYDLLEDTVEYGIIVADSDPIEQWEAAIEEDRLRELKLDVHNYSSRRWRLDTHD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 23 | Phosphorylation | VYSTKKGSGDNLLLM CEECCCCCCCCEEEE | 52.43 | 22369663 | |
| 47 | Phosphorylation | DRESDDLSGHDAFSP CCCCCCCCCCCCCCC | 40.87 | 28889911 | |
| 53 | Phosphorylation | LSGHDAFSPSKKRGK CCCCCCCCCCCCCCC | 29.95 | 23749301 | |
| 63 | Phosphorylation | KKRGKIDSITEDEIE CCCCCCCCCCCCCCH | 34.58 | 28889911 | |
| 65 | Phosphorylation | RGKIDSITEDEIEVK CCCCCCCCCCCCHHH | 41.14 | 24961812 | |
| 79 | Phosphorylation | KKLSTVATFDKLSRS HHHHHHHHHHHHHHC | 28.20 | 30377154 | |
| 236 | Phosphorylation | AKNAFKNSQKAYLSV HHHHCCCCCCEEEEH | 33.38 | 27017623 | |
| 323 | Acetylation | SNKSCSSKTPNKHPK CCCCCCCCCCCCCHH | 52.27 | 25381059 | |
| 327 | Acetylation | CSSKTPNKHPKQQLN CCCCCCCCCHHHHCC | 63.59 | 25381059 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RTC4_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RTC4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RTC4_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MCM1_YEAST | MCM1 | genetic | 27708008 | |
| STU1_YEAST | STU1 | genetic | 27708008 | |
| CND2_YEAST | BRN1 | genetic | 27708008 | |
| NSE4_YEAST | NSE4 | genetic | 27708008 | |
| CND3_YEAST | YCG1 | genetic | 27708008 | |
| MED14_YEAST | RGR1 | genetic | 27708008 | |
| SMC4_YEAST | SMC4 | genetic | 27708008 | |
| SEC22_YEAST | SEC22 | genetic | 27708008 | |
| EI2BB_YEAST | GCD7 | genetic | 27708008 | |
| BUR1_YEAST | SGV1 | genetic | 27708008 | |
| MED10_YEAST | NUT2 | genetic | 27708008 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23 AND SER-63, AND MASSSPECTROMETRY. | |
