GBP2_YEAST - dbPTM
GBP2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GBP2_YEAST
UniProt AC P25555
Protein Name Single-strand telomeric DNA-binding protein GBP2
Gene Name GBP2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 427
Subcellular Localization Nucleus . Chromosome, telomere.
Protein Description Binds single-stranded telomeric sequences of the type (TG[1-3])n in vitro. Also binds to RNA. Influences the localization of RAP1 in the nuclei. Involved in modulating telomere length..
Protein Sequence MERELGMYGNDRSRSRSPVRRRLSDDRDRYDDYNDSSSNNGNGSRRQRRDRGSRFNDRYDQSYGGSRYHDDRNWPPRRGGRGRGGSRSFRGGRGGGRGRTLGPIVERDLERQFDATKRNFENSIFVRNLTFDCTPEDLKELFGTVGEVVEADIITSKGHHRGMGTVEFTKNESVQDAISKFDGALFMDRKLMVRQDNPPPEAAKEFSKKATREEIDNGFEVFIINLPYSMNWQSLKDMFKECGHVLRADVELDFNGFSRGFGSVIYPTEDEMIRAIDTFNGMEVEGRVLEVREGRFNKRKNNDRYNQRREDLEDTRGTEPGLAQDAAVHIDETAAKFTEGVNPGGDRNCFIYCSNLPFSTARSDLFDLFGPIGKINNAELKPQENGQPTGVAVVEYENLVDADFCIQKLNNYNYGGCSLQISYARRD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMERELGMYGNDRSRS
CCCCCCCCCCCCCCC		15.8128132839
13PhosphorylationGMYGNDRSRSRSPVR
CCCCCCCCCCCCCCH		37.1519684113
15PhosphorylationYGNDRSRSRSPVRRR
CCCCCCCCCCCCHHH		38.0519684113
17PhosphorylationNDRSRSRSPVRRRLS
CCCCCCCCCCHHHCC		29.0619684113
24PhosphorylationSPVRRRLSDDRDRYD
CCCHHHCCCCCCCCC		35.3417563356
30PhosphorylationLSDDRDRYDDYNDSS
CCCCCCCCCCCCCCC		19.9128889911
33PhosphorylationDRDRYDDYNDSSSNN
CCCCCCCCCCCCCCC		20.2628889911
36PhosphorylationRYDDYNDSSSNNGNG
CCCCCCCCCCCCCCC		31.8428889911
37PhosphorylationYDDYNDSSSNNGNGS
CCCCCCCCCCCCCCC		39.6928889911
38PhosphorylationDDYNDSSSNNGNGSR
CCCCCCCCCCCCCCC		37.9628889911
44PhosphorylationSSNNGNGSRRQRRDR
CCCCCCCCCHHHHHC		28.4330377154
130PhosphorylationSIFVRNLTFDCTPED
CEEEEEEEECCCHHH		22.4528889911
169PhosphorylationGMGTVEFTKNESVQD
CCCEEEEECCHHHHH		21.3227017623
170AcetylationMGTVEFTKNESVQDA
CCEEEEECCHHHHHH		65.1324489116
180AcetylationSVQDAISKFDGALFM
HHHHHHHHCCCCEEE		41.1624489116
240AcetylationQSLKDMFKECGHVLR
HHHHHHHHHHCCEEE		45.5224489116
363PhosphorylationLPFSTARSDLFDLFG
CCCCCCCHHHHHHHC		35.8830377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GBP2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GBP2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GBP2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
THO2_YEASTTHO2physical
11805837
IMDH3_YEASTIMD3physical
11805837
SUB2_YEASTSUB2physical
11805837
THP2_YEASTTHP2physical
11805837
TEX1_YEASTTEX1physical
11805837
HPR1_YEASTHPR1physical
11805837
MFT1_YEASTMFT1physical
11805837
YRA1_YEASTYRA1physical
11805837
SUB2_YEASTSUB2physical
14769921
TEX1_YEASTTEX1physical
14769921
THO2_YEASTTHO2physical
14769921
HPR1_YEASTHPR1physical
14769921
HRB1_YEASTHRB1physical
14769921
MFT1_YEASTMFT1physical
14769921
THP2_YEASTTHP2physical
14769921
YRA1_YEASTYRA1physical
14769921
GAL1_YEASTGAL1physical
14769921
PMA1_YEASTPMA1physical
14769921
IF5A1_YEASTHYP2physical
14769921
RS5_YEASTRPS5physical
14769921
DBP2_YEASTDBP2physical
14769921
ACT_YEASTACT1physical
14769921
CTK1_YEASTCTK1physical
14769921
HPR1_YEASTHPR1physical
16554755
YRA1_YEASTYRA1physical
16554755
THP2_YEASTTHP2physical
16554755
MFT1_YEASTMFT1physical
16554755
THO2_YEASTTHO2physical
16554755
FBRL_YEASTNOP1physical
16429126
RS4A_YEASTRPS4Aphysical
16429126
RS4B_YEASTRPS4Aphysical
16429126
HPR1_YEASTHPR1physical
16429126
IMDH3_YEASTIMD3physical
16429126
THO2_YEASTTHO2physical
16429126
THP2_YEASTTHP2physical
16429126
UBX1_YEASTSHP1genetic
17314980
VPS8_YEASTVPS8genetic
17314980
SKY1_YEASTSKY1physical
17517895
SRPK1_HUMANSRPK1physical
17517895
KRR1_YEASTKRR1genetic
19061648
PT309_YEASTPET309genetic
19061648
NOP56_YEASTNOP56genetic
19061648
TAD3_YEASTTAD3genetic
19061648
RLI1_YEASTRLI1genetic
19061648
SAC3_YEASTSAC3genetic
19061648
RT103_YEASTRTT103genetic
19061648
POP8_YEASTPOP8genetic
19061648
POP7_YEASTPOP7genetic
19061648
ARC1_YEASTARC1genetic
19061648
NUP57_YEASTNUP57genetic
19061648
MAK11_YEASTMAK11genetic
19061648
THP1_YEASTTHP1genetic
19061648
RRP6_YEASTRRP6genetic
19061648
APQ12_YEASTAPQ12genetic
19061648
NOP15_YEASTNOP15genetic
19061648
PRP4_YEASTPRP4genetic
19061648
IF2G_YEASTGCD11genetic
19061648
RT109_YEASTRTT109genetic
19061648
CSF1_YEASTCSF1genetic
19061648
PRP2_YEASTPRP2genetic
19061648
CHD1_YEASTCHD1genetic
19061648
CYK3_YEASTCYK3genetic
20093466
SWF1_YEASTSWF1genetic
20093466
RT103_YEASTRTT103genetic
20093466
EAF1_YEASTEAF1genetic
20093466
PUF4_YEASTPUF4genetic
20093466
PHB2_YEASTPHB2genetic
20093466
SPO14_YEASTSPO14genetic
20093466
NKP2_YEASTNKP2genetic
20093466
MDM12_YEASTMDM12genetic
20093466
SIN3_YEASTSIN3genetic
20093466
BUB3_YEASTBUB3genetic
20093466
VPS21_YEASTVPS21genetic
20093466
GPB2_YEASTGPB2genetic
27708008
SWF1_YEASTSWF1genetic
27708008
SAC3_YEASTSAC3genetic
27708008
RT103_YEASTRTT103genetic
27708008
GET2_YEASTGET2genetic
27708008
PUF4_YEASTPUF4genetic
27708008
ASK10_YEASTASK10genetic
27708008
SPO14_YEASTSPO14genetic
27708008
DID2_YEASTDID2genetic
27708008
NKP2_YEASTNKP2genetic
27708008
YNO0_YEASTYNL140Cgenetic
27708008
MDM12_YEASTMDM12genetic
27708008
VPS21_YEASTVPS21genetic
27708008
VPH1_YEASTVPH1genetic
27708008
MEX67_YEASTMEX67physical
27951587
THO2_YEASTTHO2physical
26602689
HPR1_YEASTHPR1physical
26602689
THO2_YEASTTHO2genetic
26602689
DOM34_YEASTDOM34genetic
29158977
MEX67_YEASTMEX67physical
24452287
PRP17_YEASTCDC40physical
24452287
RRP6_YEASTRRP6physical
24452287
PRP8_YEASTPRP8genetic
24452287
PRP17_YEASTCDC40genetic
24452287
PRP43_YEASTPRP43genetic
24452287
MLP1_YEASTMLP1genetic
24452287
RRP6_YEASTRRP6genetic
24452287
MTR4_YEASTMTR4genetic
24452287
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GBP2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, AND MASSSPECTROMETRY.
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, AND MASSSPECTROMETRY.

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