| UniProt ID | SPH1_YEAST | |
|---|---|---|
| UniProt AC | Q06160 | |
| Protein Name | Protein SPH1 | |
| Gene Name | SPH1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 661 | |
| Subcellular Localization | Bud tip. Bud neck. Cytoplasm, cytoskeleton. Sites of polarized growth as bud tip, bud neck and mating projection. Hub1 is necessary for the proper location to mating projections after pheromone alpha treatment. | |
| Protein Description | Polarity-determining protein which forms a conjugate with the ubiquitin-like modifier HUB1. Involved in bud site selection and cellular morphogenesis during conjugation. Required for pseudohyphal growth.. | |
| Protein Sequence | MISSELTNDQIIDLISDYKNFKRIIEASVPEDDRRRNQNRQNRNKDLTKLSNVQFWQLTTDVNDELMKRLTDSGADASLNDLDLKRGKAQSKLSRLKDAKFHKLILDIFTEIERRNLHHLDMGTHNNGLDEGDLNFYLNDTLFESFKINDDFMSVNGIISIEVFRELKTQFTLYFQNTLHRIDPVDTTTTRLPILLETIIKIAKLIGDLLPVLSSVSLQSSLENEIVYLKSALSHAITSTRYFLTYGDLIPRIVAQSSISEVIFAFCNIAQIVKIKSTSRDDISRNEGELSDIEAGMKPLKIIEKVKNEKNGKDISSLGDSGSTAVSFPSSGKPITKKSDMPVVVASPSISIIEKSESSIRESGKVRNNTSGETNLASVSPLKNTKNSSRITSEPSPREGLPLKVVSNSRSPSPQGNTLPLIGKFRQDYQASPPKKVITKPVAETAKPYANIPPAADVLYSPTVTKMRKFREKVQKFAPNSGLGLRISTSEENLNNSDVNSTTHNANINNLVEFVESKSMVVLPMAQGILNDVQASKSKLFKSARSVSRLCQNSIEIIPILESVIDMTTKAMVQKSFKLDLGEHCKEIIERLTDCSQKLSELCTYGCDSTKLGKKRFYQKLADILMEVTKRTRELVECVKMANRQTLSQDLSSFFNYRSVQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 154 | Phosphorylation | KINDDFMSVNGIISI EECCCCCCCCCEEEH | 16.66 | 28132839 | |
| 160 | Phosphorylation | MSVNGIISIEVFREL CCCCCEEEHHHHHHH | 15.69 | 28132839 | |
| 291 | Phosphorylation | SRNEGELSDIEAGMK HCCCCCHHHHHCCCC | 32.04 | 26447709 | |
| 321 | Phosphorylation | DISSLGDSGSTAVSF CCHHHCCCCCEEEEC | 32.61 | 30377154 | |
| 323 | Phosphorylation | SSLGDSGSTAVSFPS HHHCCCCCEEEECCC | 19.69 | 30377154 | |
| 347 | Phosphorylation | DMPVVVASPSISIIE CCCEEEECCCEEEEE | 13.94 | 21440633 | |
| 349 | Phosphorylation | PVVVASPSISIIEKS CEEEECCCEEEEECC | 26.86 | 21440633 | |
| 351 | Phosphorylation | VVASPSISIIEKSES EEECCCEEEEECCHH | 23.11 | 21440633 | |
| 380 | Phosphorylation | ETNLASVSPLKNTKN CCCCCCCCCCCCCCC | 23.24 | 21440633 | |
| 396 | Phosphorylation | SRITSEPSPREGLPL CCCCCCCCCCCCCCC | 32.32 | 21440633 | |
| 413 | Phosphorylation | VSNSRSPSPQGNTLP EECCCCCCCCCCCCC | 30.97 | 23749301 | |
| 432 | Phosphorylation | FRQDYQASPPKKVIT CHHHHCCCCCCCEEC | 26.64 | 21440633 | |
| 600 | Phosphorylation | TDCSQKLSELCTYGC HHHHHHHHHHHHCCC | 35.24 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SPH1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPH1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPH1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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