| UniProt ID | PIB2_YEAST | |
|---|---|---|
| UniProt AC | P53191 | |
| Protein Name | Phosphatidylinositol 3-phosphate-binding protein 2 | |
| Gene Name | PIB2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 635 | |
| Subcellular Localization |
Vacuole membrane Peripheral membrane protein . |
|
| Protein Description | ||
| Protein Sequence | MTALHSVSKTPAIKEEEEDGDERDGRGVPLGPRNHDYRGRKGDEESGADTVTSPITFEKKKIAPRASTHSEQSILSSISLKSMVNQHRQQQLQQESSTGAGTGFVDRKQQIQSPAMVSILRKNSAEENVRSSHSSKLGEGQIDGRKASASKEIGKTLPFTDDQRSNPELDPTNSVVDVSRGKNTKSKTVFNELEDDADDDDEVRQKNLTTQALRKLSSFKMNASSNLRLSKENKAKESSSSSTSSVSSSSTSKVENIVDKLTTTNSSSMSQLRFGNTNVIIDSVNHAAKPPHQQMLRKPSLEFLPQPASSTNLNFNSNKHKSNVRQISNPKKPLYIPAVLRKVSETNITNDDLLNATLSSYYKKASNLEHGFNPSKSQSASVQNANNLRIISSQSSVQSNTSSILESYKNKISSYLFPNSIPNSDRINLIPTISNRNSARVNPPTKDHWIPDSKRNSCRYCHKPFTLWERKHHCRHCGDIFCQDHLRHWLYLDSQANFIMINELNNGGINGGGTLCKICDDCLVEYENLSTTNHNANTNEDNINVEEGEDDDNDNRKKLRNYYKNRQMNALFRPKKGGSSQEHATVDRDTTTPIQVKSNDEEADNENTGGEQEEGNDVLGSVIGSVPANWNWSSF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MTALHSVSK ------CCCCCCCCC | 37.62 | 22369663 | |
| 6 | Phosphorylation | --MTALHSVSKTPAI --CCCCCCCCCCCCC | 29.01 | 22369663 | |
| 8 | Phosphorylation | MTALHSVSKTPAIKE CCCCCCCCCCCCCCC | 33.55 | 22369663 | |
| 10 | Phosphorylation | ALHSVSKTPAIKEEE CCCCCCCCCCCCCCC | 15.50 | 28889911 | |
| 46 | Phosphorylation | GRKGDEESGADTVTS CCCCCCCCCCCCCCC | 36.91 | 22890988 | |
| 50 | Phosphorylation | DEESGADTVTSPITF CCCCCCCCCCCCCEE | 25.75 | 22890988 | |
| 52 | Phosphorylation | ESGADTVTSPITFEK CCCCCCCCCCCEECC | 30.77 | 22369663 | |
| 53 | Phosphorylation | SGADTVTSPITFEKK CCCCCCCCCCEECCC | 15.23 | 22369663 | |
| 56 | Phosphorylation | DTVTSPITFEKKKIA CCCCCCCEECCCCCC | 29.17 | 22369663 | |
| 67 | Phosphorylation | KKIAPRASTHSEQSI CCCCCCCCCCCHHHH | 28.12 | 22369663 | |
| 68 | Phosphorylation | KIAPRASTHSEQSIL CCCCCCCCCCHHHHH | 28.56 | 22369663 | |
| 70 | Phosphorylation | APRASTHSEQSILSS CCCCCCCCHHHHHHH | 37.10 | 22369663 | |
| 73 | Phosphorylation | ASTHSEQSILSSISL CCCCCHHHHHHHHHH | 22.80 | 22369663 | |
| 76 | Phosphorylation | HSEQSILSSISLKSM CCHHHHHHHHHHHHH | 24.77 | 22369663 | |
| 77 | Phosphorylation | SEQSILSSISLKSMV CHHHHHHHHHHHHHH | 16.86 | 22369663 | |
| 79 | Phosphorylation | QSILSSISLKSMVNQ HHHHHHHHHHHHHHH | 31.52 | 22369663 | |
| 82 | Phosphorylation | LSSISLKSMVNQHRQ HHHHHHHHHHHHHHH | 33.00 | 21440633 | |
| 96 | Phosphorylation | QQQLQQESSTGAGTG HHHHHHHHHCCCCCC | 28.94 | 21440633 | |
| 97 | Phosphorylation | QQLQQESSTGAGTGF HHHHHHHHCCCCCCC | 30.06 | 23749301 | |
| 98 | Phosphorylation | QLQQESSTGAGTGFV HHHHHHHCCCCCCCC | 40.09 | 25752575 | |
| 102 | Phosphorylation | ESSTGAGTGFVDRKQ HHHCCCCCCCCCHHH | 27.23 | 19823750 | |
| 113 | Phosphorylation | DRKQQIQSPAMVSIL CHHHHCCCHHHHHHH | 19.09 | 21551504 | |
| 118 | Phosphorylation | IQSPAMVSILRKNSA CCCHHHHHHHHHCCH | 11.65 | 29688323 | |
| 124 | Phosphorylation | VSILRKNSAEENVRS HHHHHHCCHHHHHHH | 39.84 | 25533186 | |
| 131 | Phosphorylation | SAEENVRSSHSSKLG CHHHHHHHCCHHCCC | 28.28 | 20377248 | |
| 132 | Phosphorylation | AEENVRSSHSSKLGE HHHHHHHCCHHCCCC | 19.47 | 30377154 | |
| 134 | Phosphorylation | ENVRSSHSSKLGEGQ HHHHHCCHHCCCCCC | 30.99 | 29136822 | |
| 135 | Phosphorylation | NVRSSHSSKLGEGQI HHHHCCHHCCCCCCC | 26.86 | 24961812 | |
| 148 | Phosphorylation | QIDGRKASASKEIGK CCCCCCCCCCCHHCC | 35.79 | 20377248 | |
| 150 | Phosphorylation | DGRKASASKEIGKTL CCCCCCCCCHHCCCC | 28.46 | 21440633 | |
| 156 | Phosphorylation | ASKEIGKTLPFTDDQ CCCHHCCCCCCCCCC | 34.16 | 22369663 | |
| 160 | Phosphorylation | IGKTLPFTDDQRSNP HCCCCCCCCCCCCCC | 36.40 | 25521595 | |
| 165 | Phosphorylation | PFTDDQRSNPELDPT CCCCCCCCCCCCCCC | 51.62 | 22369663 | |
| 172 | Phosphorylation | SNPELDPTNSVVDVS CCCCCCCCCCEEECC | 39.53 | 22369663 | |
| 174 | Phosphorylation | PELDPTNSVVDVSRG CCCCCCCCEEECCCC | 26.46 | 21082442 | |
| 179 | Phosphorylation | TNSVVDVSRGKNTKS CCCEEECCCCCCCCC | 30.74 | 26447709 | |
| 209 | Phosphorylation | EVRQKNLTTQALRKL HHHHHHHHHHHHHHH | 26.67 | 19795423 | |
| 210 | Phosphorylation | VRQKNLTTQALRKLS HHHHHHHHHHHHHHH | 18.27 | 21440633 | |
| 217 | Phosphorylation | TQALRKLSSFKMNAS HHHHHHHHCCCCCCC | 36.44 | 19684113 | |
| 218 | Phosphorylation | QALRKLSSFKMNASS HHHHHHHCCCCCCCC | 39.04 | 19684113 | |
| 224 | Phosphorylation | SSFKMNASSNLRLSK HCCCCCCCCCCCCCC | 18.11 | 22369663 | |
| 225 | Phosphorylation | SFKMNASSNLRLSKE CCCCCCCCCCCCCCC | 37.16 | 22369663 | |
| 230 | Phosphorylation | ASSNLRLSKENKAKE CCCCCCCCCCCCCCC | 31.33 | 21551504 | |
| 242 | Phosphorylation | AKESSSSSTSSVSSS CCCCCCCCCCCCCCC | 33.97 | 28889911 | |
| 244 | Phosphorylation | ESSSSSTSSVSSSST CCCCCCCCCCCCCCC | 30.59 | 30377154 | |
| 245 | Phosphorylation | SSSSSTSSVSSSSTS CCCCCCCCCCCCCCH | 26.55 | 28889911 | |
| 248 | Phosphorylation | SSTSSVSSSSTSKVE CCCCCCCCCCCHHHH | 26.59 | 28889911 | |
| 250 | Phosphorylation | TSSVSSSSTSKVENI CCCCCCCCCHHHHHH | 38.35 | 28889911 | |
| 262 | Phosphorylation | ENIVDKLTTTNSSSM HHHHHHHHCCCCCCC | 37.00 | 22369663 | |
| 263 | Phosphorylation | NIVDKLTTTNSSSMS HHHHHHHCCCCCCCC | 34.12 | 22369663 | |
| 264 | Phosphorylation | IVDKLTTTNSSSMSQ HHHHHHCCCCCCCCC | 28.06 | 22369663 | |
| 266 | Phosphorylation | DKLTTTNSSSMSQLR HHHHCCCCCCCCCEE | 23.00 | 22369663 | |
| 267 | Phosphorylation | KLTTTNSSSMSQLRF HHHCCCCCCCCCEEC | 31.93 | 22369663 | |
| 268 | Phosphorylation | LTTTNSSSMSQLRFG HHCCCCCCCCCEECC | 23.44 | 22369663 | |
| 270 | Phosphorylation | TTNSSSMSQLRFGNT CCCCCCCCCEECCCC | 28.19 | 22369663 | |
| 300 | Phosphorylation | QQMLRKPSLEFLPQP HHHCCCCCCCCCCCC | 43.49 | 22369663 | |
| 309 | Phosphorylation | EFLPQPASSTNLNFN CCCCCCCCCCCCCCC | 44.36 | 22369663 | |
| 310 | Phosphorylation | FLPQPASSTNLNFNS CCCCCCCCCCCCCCC | 24.34 | 22369663 | |
| 311 | Phosphorylation | LPQPASSTNLNFNSN CCCCCCCCCCCCCCC | 41.03 | 22369663 | |
| 317 | Phosphorylation | STNLNFNSNKHKSNV CCCCCCCCCCCCCCC | 43.02 | 22369663 | |
| 344 | Phosphorylation | PAVLRKVSETNITND HHHHHHHHHCCCCCH | 41.56 | 22369663 | |
| 346 | Phosphorylation | VLRKVSETNITNDDL HHHHHHHCCCCCHHH | 25.14 | 22369663 | |
| 349 | Phosphorylation | KVSETNITNDDLLNA HHHHCCCCCHHHHHH | 34.36 | 22369663 | |
| 357 | Phosphorylation | NDDLLNATLSSYYKK CHHHHHHHHHHHHHH | 26.54 | 22369663 | |
| 359 | Phosphorylation | DLLNATLSSYYKKAS HHHHHHHHHHHHHHH | 16.37 | 22369663 | |
| 360 | Phosphorylation | LLNATLSSYYKKASN HHHHHHHHHHHHHHC | 35.28 | 22369663 | |
| 361 | Phosphorylation | LNATLSSYYKKASNL HHHHHHHHHHHHHCC | 18.87 | 22369663 | |
| 362 | Phosphorylation | NATLSSYYKKASNLE HHHHHHHHHHHHCCC | 14.14 | 22369663 | |
| 376 | Ubiquitination | EHGFNPSKSQSASVQ CCCCCCCCCCCCCCC | 54.49 | 23749301 | |
| 377 | Phosphorylation | HGFNPSKSQSASVQN CCCCCCCCCCCCCCC | 33.43 | 22369663 | |
| 379 | Phosphorylation | FNPSKSQSASVQNAN CCCCCCCCCCCCCHH | 29.60 | 22369663 | |
| 381 | Phosphorylation | PSKSQSASVQNANNL CCCCCCCCCCCHHCC | 29.49 | 22369663 | |
| 392 | Phosphorylation | ANNLRIISSQSSVQS HHCCEEEECCHHHHC | 21.69 | 23749301 | |
| 393 | Phosphorylation | NNLRIISSQSSVQSN HCCEEEECCHHHHCC | 24.55 | 22369663 | |
| 395 | Phosphorylation | LRIISSQSSVQSNTS CEEEECCHHHHCCHH | 34.13 | 22369663 | |
| 396 | Phosphorylation | RIISSQSSVQSNTSS EEEECCHHHHCCHHH | 19.28 | 22369663 | |
| 399 | Phosphorylation | SSQSSVQSNTSSILE ECCHHHHCCHHHHHH | 39.66 | 22369663 | |
| 401 | Phosphorylation | QSSVQSNTSSILESY CHHHHCCHHHHHHHH | 29.15 | 22369663 | |
| 402 | Phosphorylation | SSVQSNTSSILESYK HHHHCCHHHHHHHHH | 21.45 | 22369663 | |
| 403 | Phosphorylation | SVQSNTSSILESYKN HHHCCHHHHHHHHHH | 29.20 | 22369663 | |
| 407 | Phosphorylation | NTSSILESYKNKISS CHHHHHHHHHHHHHH | 37.65 | 22369663 | |
| 408 | Phosphorylation | TSSILESYKNKISSY HHHHHHHHHHHHHHH | 14.81 | 28132839 | |
| 411 | Ubiquitination | ILESYKNKISSYLFP HHHHHHHHHHHHCCC | 39.55 | 24961812 | |
| 411 | Acetylation | ILESYKNKISSYLFP HHHHHHHHHHHHCCC | 39.55 | 24489116 | |
| 413 | Phosphorylation | ESYKNKISSYLFPNS HHHHHHHHHHCCCCC | 17.97 | 24961812 | |
| 414 | Phosphorylation | SYKNKISSYLFPNSI HHHHHHHHHCCCCCC | 29.36 | 24961812 | |
| 415 | Phosphorylation | YKNKISSYLFPNSIP HHHHHHHHCCCCCCC | 12.93 | 24961812 | |
| 420 | Phosphorylation | SSYLFPNSIPNSDRI HHHCCCCCCCCCCCE | 39.39 | 21440633 | |
| 424 | Phosphorylation | FPNSIPNSDRINLIP CCCCCCCCCCEEEEC | 23.94 | 21440633 | |
| 432 | Phosphorylation | DRINLIPTISNRNSA CCEEEECCCCCCCCC | 30.00 | 24961812 | |
| 434 | Phosphorylation | INLIPTISNRNSARV EEEECCCCCCCCCCC | 32.01 | 28889911 | |
| 438 | Phosphorylation | PTISNRNSARVNPPT CCCCCCCCCCCCCCC | 17.76 | 24961812 | |
| 445 | Phosphorylation | SARVNPPTKDHWIPD CCCCCCCCCCCCCCC | 50.81 | 24961812 | |
| 579 | Phosphorylation | FRPKKGGSSQEHATV CCCCCCCCCCCCEEE | 37.20 | 21440633 | |
| 592 | Phosphorylation | TVDRDTTTPIQVKSN EECCCCCCCEEEECC | 22.08 | 21440633 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PIB2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PIB2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PIB2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6; THR-52; SER-53;SER-113; SER-124; THR-160; SER-165; THR-172; SER-174; SER-225;SER-267; SER-268; SER-300; SER-344; THR-346; SER-396; SER-399 ANDSER-420, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53; SER-124; SER-165;SER-300 AND SER-344, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148, AND MASSSPECTROMETRY. | |
