SCC2_YEAST - dbPTM
SCC2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SCC2_YEAST
UniProt AC Q04002
Protein Name Sister chromatid cohesion protein 2
Gene Name SCC2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1493
Subcellular Localization Nucleus . Chromosome, centromere . Associates with chromatin.
Protein Description Plays a structural role in chromatin and is involved in sister chromatid cohesion. [PubMed: 9990856]
Protein Sequence MSYPGKDKNIPGRIIEALEDLPLSYLVPKDGLAALVNAPMRVSLPFDKTIFTSADDGRDVNINVLGTANSTTSSIKNEAEKERLVFKRPSNFTSSANSVDYVPTNFLEGLSPLAQSVLSTHKGLNDSINIEKKSEIVSRPEAKHKLESVTSNAGNLSFNDNSSNKKTKTSTGVTMTQANLAEQYLNDLKNILDIVGFDQNSAEIGNIEYWLQLPNKKFVLTTNCLTKLQMTIKNITDNPQLSNSIEITWLLRLLDVMVCNIKFSKSSLKMGLDDSMLRYIALLSTIVLFNIFLLGKNDSNLHRESYIMEPVNFLSDLIESLKILTIEYGSLKIEFDTFQEALELLPKYIRNGPFLDDNVTAKLVYIFSDLLMNNDIEATTNIQFQSFWDNVKRISSDILVSLFGSFDQQRGFIIEELLSHIEKLPTKRIQKKLRKVGNQNIYITDFTFTLMSMLENINCYSFCNQMKDIAPENIDLLKNEYKKQEEFLFNIVEHINDTILERFFKNPSALRYVIDNFVQDLLLLISSPQWPVTEKILSSLLKRLLSVYSPSMQVSANIETICLQLIGNIGSTIFDIKCSTRDHEDNNLIKMINYPETLPHFFKSFEECIAYNETIKCRRSATRFLWNLRLGTILILEEYTKDAKEQIITVDNELKKILEQIKDGGLGPELENREADFSTIKLDYFSILHAFELLNLYDPYLKLILSLLAKDKIKLRSTAIKCLSMLASKDKVILSNPMVKETIHRRLNDSSASVKDAILDLVSINSSYFEFYQQINNNYNDDSIMVRKHVLRINEKMYDETNDIVTKVYVIARILMKIEDEEDNIIDMARLILLNRWILKVHEVLDQPEKLKEISSSVLLVMSRVAIMNEKCSQLFDLFLNFYLLNKEAHSKEAYDKITHVLTILTDFLVQKIVELNSDDTNEKNSIVDKQNFLNLLAKFADSTVSFLTKDHITALYPYMVSDEKSDFHYYILQVFRCTFEKLANFKQKFLYDLETTLLSRLPKMNVREIDEAMPLIWSVATHRHDTARVAKACSSCLSHLHPYINKANNEEAAIVVDGKLQRLIYLSTGFARFCFPKPSNDKIAFLQEGETLYEHITKCLLVLSKDKITHVIRRVAVKNLTKLCGNHPKLFNSRHVLHLLDKEFQSDQLDIKLVILESLYDLFLLEERKSVRNTGVNSTLSSNSILKKKLLKTNRVEFANDGVCSALATRFLDNILQLCLLRDLKNSLVAIRLLKLILKFGYTNPSHSIPTVIALFASTSQYIRHVAYELLEDLFEKYETLVFSSLSRGVTKAIHYSIHTDEKYYYKHDHFLSLLEKLCGTGKKNGPKFFKVLKRIMQSYLDDITDLTSTNSSVQKSIFVLCTNISNITFVSQYDLVSLLKTIDLTTDRLKEVIMDEIGDNVSSLSVSEEKLSGIILIQLSLQDLGTYLLHLYGLRDDVLLLDIVEESELKNKQLPAKKPDISKFSAQLENIEQYSSNGKLLTYFRKHVKDT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
43PhosphorylationVNAPMRVSLPFDKTI
HCCCEEEECCCCCCE
21.6926354421
67PhosphorylationVNINVLGTANSTTSS
EEEEEEEECCCCCHH
20.6426354421
74PhosphorylationTANSTTSSIKNEAEK
ECCCCCHHHCCHHHH
35.1726354421
127PhosphorylationTHKGLNDSINIEKKS
HCCCCCCCCCHHHHH
19.2327214570
133UbiquitinationDSINIEKKSEIVSRP
CCCCHHHHHHHCCCH
40.3022106047
157PhosphorylationTSNAGNLSFNDNSSN
CCCCCCCCCCCCCCC
26.4627017623
162PhosphorylationNLSFNDNSSNKKTKT
CCCCCCCCCCCCEEC
37.8426354421
163PhosphorylationLSFNDNSSNKKTKTS
CCCCCCCCCCCEECC
59.9526354421
167PhosphorylationDNSSNKKTKTSTGVT
CCCCCCCEECCCCCC
40.9628889911
169PhosphorylationSSNKKTKTSTGVTMT
CCCCCEECCCCCCHH
36.4328889911
174PhosphorylationTKTSTGVTMTQANLA
EECCCCCCHHHHHHH
18.8228889911
176PhosphorylationTSTGVTMTQANLAEQ
CCCCCCHHHHHHHHH
18.3728889911
184PhosphorylationQANLAEQYLNDLKNI
HHHHHHHHHHHHHHH
10.0528889911
231PhosphorylationCLTKLQMTIKNITDN
HHHHHHHHHHCCCCC
18.8126354421
236PhosphorylationQMTIKNITDNPQLSN
HHHHHCCCCCCCCCC
38.8326354421
305PhosphorylationDSNLHRESYIMEPVN
CCCCCCHHHCCCHHH
21.6626354421
320PhosphorylationFLSDLIESLKILTIE
HHHHHHHHCCCEEEE
28.1526354421
360PhosphorylationPFLDDNVTAKLVYIF
CCCCCCHHHHHHHHH
25.0826354421
505AcetylationTILERFFKNPSALRY
HHHHHHHCCHHHHHH
66.3024489116
735PhosphorylationSKDKVILSNPMVKET
CCCEEEECCHHHHHH
27.9721126336
753PhosphorylationRLNDSSASVKDAILD
HHCCCCCCHHHHHHH
31.4826354421
897UbiquitinationHSKEAYDKITHVLTI
CCHHHHHHHHHHHHH
36.5123749301
1004AcetylationTLLSRLPKMNVREID
HHHHCCCCCCHHHHH
47.9325381059
1179PhosphorylationVRNTGVNSTLSSNSI
HHCCCCCCCCCCCHH
28.4626354421
1182PhosphorylationTGVNSTLSSNSILKK
CCCCCCCCCCHHHHH
27.8026354421
1183PhosphorylationGVNSTLSSNSILKKK
CCCCCCCCCHHHHHH
37.4026354421
1185PhosphorylationNSTLSSNSILKKKLL
CCCCCCCHHHHHHHH
31.1126354421
1306PhosphorylationIHTDEKYYYKHDHFL
CCCCCCCCCCCHHHH
19.6719779198
1307PhosphorylationHTDEKYYYKHDHFLS
CCCCCCCCCCHHHHH
9.9619779198
1314PhosphorylationYKHDHFLSLLEKLCG
CCCHHHHHHHHHHHC
29.9319779198
1322PhosphorylationLLEKLCGTGKKNGPK
HHHHHHCCCCCCCHH
44.8528889911
1464PhosphorylationPAKKPDISKFSAQLE
CCCCCCHHHHHHHHH
34.7228889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SCC2_YEAST !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
43SPhosphorylation

26354421
67TPhosphorylation

26354421
74SPhosphorylation

26354421
127SPhosphorylation

26354421
157SPhosphorylation

26354421
162SPhosphorylation

26354421
163SPhosphorylation

26354421
231TPhosphorylation

26354421
236TPhosphorylation

26354421
305SPhosphorylation

26354421
320SPhosphorylation

26354421
360TPhosphorylation

26354421
1179SPhosphorylation

26354421
1183SPhosphorylation

26354421

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SCC2_YEAST !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SCC4_YEASTSCC4physical
14614819
SMC1_YEASTSMC1physical
14614819
SMC3_YEASTSMC3physical
14614819
SCC3_YEASTIRR1physical
14614819
SCC4_YEASTSCC4physical
10882066
FEN1_YEASTRAD27genetic
19846659
CTF4_YEASTCTF4genetic
19846659
SCC1_YEASTMCD1physical
19797771
LTE1_YEASTLTE1genetic
20093466
YBQ6_YEASTYBR056Wgenetic
20093466
IML3_YEASTIML3genetic
20093466
EF1A_YEASTTEF2genetic
20093466
AIM4_YEASTAIM4genetic
20093466
MRC1_YEASTMRC1genetic
20093466
DCC1_YEASTDCC1genetic
20093466
PAT1_YEASTPAT1genetic
20093466
MBP1_YEASTMBP1genetic
20093466
RAD61_YEASTRAD61genetic
20093466
CHL4_YEASTCHL4genetic
20093466
SWM1_YEASTSWM1genetic
20093466
MCM21_YEASTMCM21genetic
20093466
MSN5_YEASTMSN5genetic
20093466
LSM6_YEASTLSM6genetic
20093466
GET2_YEASTGET2genetic
20093466
ODPA_YEASTPDA1genetic
20093466
SA155_YEASTSAP155genetic
20093466
CNN1_YEASTCNN1genetic
20093466
XRN1_YEASTXRN1genetic
20093466
MAD1_YEASTMAD1genetic
20093466
SLX9_YEASTSLX9genetic
20093466
UBR1_YEASTUBR1genetic
20093466
RS27B_YEASTRPS27Bgenetic
20093466
NMD2_YEASTNMD2genetic
20093466
STB5_YEASTSTB5genetic
20093466
CTF8_YEASTCTF8genetic
20093466
DOA10_YEASTSSM4genetic
20093466
RS21B_YEASTRPS21Bgenetic
20093466
LSM1_YEASTLSM1genetic
20093466
SRS2_YEASTSRS2genetic
20093466
CUL8_YEASTRTT101genetic
20093466
MAD2_YEASTMAD2genetic
20093466
MOG1_YEASTMOG1genetic
20093466
JHD2_YEASTJHD2genetic
20093466
MCM22_YEASTMCM22genetic
20093466
FEN1_YEASTRAD27genetic
20093466
EF1G2_YEASTTEF4genetic
20093466
FABG_YEASTOAR1genetic
20093466
TCD2_YEASTTCD2genetic
20093466
BCH2_YEASTBCH2genetic
20093466
SIC1_YEASTSIC1genetic
20093466
APC9_YEASTAPC9genetic
20093466
DPH6_YEASTDPH6genetic
20093466
SWI6_YEASTSWI6genetic
20093466
PFD6_YEASTYKE2genetic
20093466
VRP1_YEASTVRP1genetic
20093466
CTF3_YEASTCTF3genetic
20093466
PPZ1_YEASTPPZ1genetic
20093466
CSM3_YEASTCSM3genetic
20093466
CTF18_YEASTCTF18genetic
20093466
CIK1_YEASTCIK1genetic
20093466
YM91_YEASTYMR310Cgenetic
20093466
PFD4_YEASTGIM3genetic
20093466
EOS1_YEASTEOS1genetic
20093466
MAS5_YEASTYDJ1genetic
20093466
TOP1_YEASTTOP1genetic
20093466
2A5D_YEASTRTS1genetic
20093466
BUB3_YEASTBUB3genetic
20093466
ELG1_YEASTELG1genetic
20093466
DCI1_YEASTDCI1genetic
20093466
KES1_YEASTKES1genetic
20093466
CTF19_YEASTCTF19genetic
20093466
IRC15_YEASTIRC15genetic
20093466
CHL1_YEASTCHL1genetic
20093466
YME1_YEASTYME1genetic
20093466
MCM16_YEASTMCM16genetic
20093466
CG22_YEASTCLB2genetic
20093466
CTF4_YEASTCTF4genetic
20093466
KAR3_YEASTKAR3genetic
20093466
RFC5_YEASTRFC5genetic
20980821
ELG1_YEASTELG1genetic
20980821
SPO11_YEASTSPO11genetic
21508318
SCC3_YEASTIRR1genetic
21508318
SPC72_YEASTSPC72physical
22875988
ARE1_YEASTARE1physical
22875988
SPR3_YEASTSPR3physical
22875988
SED5_YEASTSED5physical
22875988
CTF19_YEASTCTF19physical
22875988
PFD4_YEASTGIM3genetic
22412391
APC10_YEASTDOC1genetic
22412391
DCC1_YEASTDCC1genetic
22412391
CTF8_YEASTCTF8genetic
22412391
CTF4_YEASTCTF4genetic
22412391
CSM3_YEASTCSM3genetic
22412391
CHL1_YEASTCHL1genetic
22412391
RS31_YEASTRPS31genetic
22412391
BIM1_YEASTBIM1genetic
22412391
KAR3_YEASTKAR3genetic
22412391
IRC15_YEASTIRC15genetic
22412391
NAA25_YEASTMDM20genetic
22412391
MRC1_YEASTMRC1genetic
22412391
CIK1_YEASTCIK1genetic
22412391
SPT10_YEASTSPT10genetic
22412391
MCM22_YEASTMCM22genetic
22412391
MCM21_YEASTMCM21genetic
22412391
CTF3_YEASTCTF3genetic
22412391
CTF19_YEASTCTF19genetic
22412391
IML3_YEASTIML3genetic
22412391
BUB3_YEASTBUB3genetic
22412391
HSF_YEASTHSF1genetic
22412391
PFD3_YEASTPAC10genetic
22412391
RPN11_YEASTRPN11genetic
22412391
FEN1_YEASTRAD27genetic
22412391
TOF1_YEASTTOF1genetic
22412391
YPR1_YEASTYPR1genetic
22412391
SWI6_YEASTSWI6genetic
22412391
STU1_YEASTSTU1genetic
22412391
CHL4_YEASTCHL4genetic
22412391
PML39_YEASTPML39genetic
22412391
PCF11_YEASTPCF11genetic
22412391
XRN1_YEASTXRN1genetic
22412391
GPI15_YEASTGPI15genetic
22412391
I23O_YEASTBNA2genetic
22412391
EAF3_YEASTEAF3genetic
22412391
ARC1_YEASTARC1genetic
22412391
SAC3_YEASTSAC3genetic
22412391
RS16A_YEASTRPS16Bgenetic
22412391
RS16B_YEASTRPS16Bgenetic
22412391
RAD61_YEASTRAD61genetic
22412391
SMC1_YEASTSMC1physical
23499533
SMC3_YEASTSMC3physical
23499533
SCC1_YEASTMCD1physical
23499533
SCC3_YEASTIRR1physical
23499533
PDS5_YEASTPDS5physical
23499533
SCC2_YEASTSCC2physical
23499533
SCC4_YEASTSCC4physical
23499533
SCC4_YEASTSCC4physical
24778232
SCC4_YEASTSCC4physical
26038942
NSE4_YEASTNSE4genetic
27708008
DAD1_YEASTDAD1genetic
27708008
ACT_YEASTACT1genetic
27708008
COPD_YEASTRET2genetic
27708008
ESP1_YEASTESP1genetic
27708008
CDC12_YEASTCDC12genetic
27708008
ATC7_YEASTNEO1genetic
27708008
CDC11_YEASTCDC11genetic
27708008
SMC6_YEASTSMC6genetic
27708008
TAF8_YEASTTAF8genetic
27708008
HMCS_YEASTERG13genetic
27708008
GPI15_YEASTGPI15genetic
27708008
SMP3_YEASTSMP3genetic
27708008
CDC24_YEASTCDC24genetic
27708008
STU1_YEASTSTU1genetic
27708008
CDC27_YEASTCDC27genetic
27708008
CND2_YEASTBRN1genetic
27708008
TSC3_YEASTTSC3genetic
27708008
RFC5_YEASTRFC5genetic
27708008
CKS1_YEASTCKS1genetic
27708008
SLI15_YEASTSLI15genetic
27708008
MED8_YEASTMED8genetic
27708008
KRR1_YEASTKRR1genetic
27708008
SCC1_YEASTMCD1genetic
27708008
APC11_YEASTAPC11genetic
27708008
RPN6_YEASTRPN6genetic
27708008
DPOD_YEASTPOL3genetic
27708008
RPB1_YEASTRPO21genetic
27708008
NOP14_YEASTNOP14genetic
27708008
FAL1_YEASTFAL1genetic
27708008
CND3_YEASTYCG1genetic
27708008
PSB3_YEASTPUP3genetic
27708008
SCC4_YEASTSCC4genetic
27708008
SMC1_YEASTSMC1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
RPN11_YEASTRPN11genetic
27708008
ECO1_YEASTECO1genetic
27708008
RPN12_YEASTRPN12genetic
27708008
PRS8_YEASTRPT6genetic
27708008
HSF_YEASTHSF1genetic
27708008
NBP35_YEASTNBP35genetic
27708008
SP105_YEASTSPC105genetic
27708008
CDC20_YEASTCDC20genetic
27708008
TEL2_YEASTTEL2genetic
27708008
DAM1_YEASTDAM1genetic
27708008
NUP57_YEASTNUP57genetic
27708008
SYYC_YEASTTYS1genetic
27708008
BRL1_YEASTBRL1genetic
27708008
YHS2_YEASTCIA2genetic
27708008
DNA2_YEASTDNA2genetic
27708008
CDC23_YEASTCDC23genetic
27708008
CTF8_YEASTCTF8genetic
27708008
SMC3_YEASTSMC3genetic
27708008
IF2A_YEASTSUI2genetic
27708008
ESS1_YEASTESS1genetic
27708008
NUP85_YEASTNUP85genetic
27708008
RFC2_YEASTRFC2genetic
27708008
CDC16_YEASTCDC16genetic
27708008
PRS7_YEASTRPT1genetic
27708008
SED5_YEASTSED5genetic
27708008
STU2_YEASTSTU2genetic
27708008
BOS1_YEASTBOS1genetic
27708008
APC2_YEASTAPC2genetic
27708008
NEP1_YEASTEMG1genetic
27708008
CD123_YEASTCDC123genetic
27708008
IMB1_YEASTKAP95genetic
27708008
SEN1_YEASTSEN1genetic
27708008
NBP1_YEASTNBP1genetic
27708008
ORC1_YEASTORC1genetic
27708008
PDS5_YEASTPDS5genetic
27708008
HAS1_YEASTHAS1genetic
27708008
LCB1_YEASTLCB1genetic
27708008
RFC4_YEASTRFC4genetic
27708008
MED7_YEASTMED7genetic
27708008
MED4_YEASTMED4genetic
27708008
APC5_YEASTAPC5genetic
27708008
PRS10_YEASTRPT4genetic
27708008
EIF3B_YEASTPRT1genetic
27708008
IPL1_YEASTIPL1genetic
27708008
DIM1_YEASTDIM1genetic
27708008
RPN7_YEASTRPN7genetic
27708008
BUR1_YEASTSGV1genetic
27708008
ORC4_YEASTORC4genetic
27708008
LTE1_YEASTLTE1genetic
27708008
NU170_YEASTNUP170genetic
27708008
IML3_YEASTIML3genetic
27708008
EF1A_YEASTTEF2genetic
27708008
DCC1_YEASTDCC1genetic
27708008
MRC1_YEASTMRC1genetic
27708008
ELO2_YEASTELO2genetic
27708008
BUD31_YEASTBUD31genetic
27708008
PAT1_YEASTPAT1genetic
27708008
PDP2_YEASTPTC6genetic
27708008
MBP1_YEASTMBP1genetic
27708008
RS29B_YEASTRPS29Bgenetic
27708008
CYK3_YEASTCYK3genetic
27708008
RAD61_YEASTRAD61genetic
27708008
MSN5_YEASTMSN5genetic
27708008
LSM6_YEASTLSM6genetic
27708008
GET2_YEASTGET2genetic
27708008
XRN1_YEASTXRN1genetic
27708008
PFD3_YEASTPAC10genetic
27708008
SLX9_YEASTSLX9genetic
27708008
UBR1_YEASTUBR1genetic
27708008
BUB1_YEASTBUB1genetic
27708008
RS27B_YEASTRPS27Bgenetic
27708008
THIK_YEASTPOT1genetic
27708008
MAD2_YEASTMAD2genetic
27708008
CUL8_YEASTRTT101genetic
27708008
LSM1_YEASTLSM1genetic
27708008
RS21B_YEASTRPS21Bgenetic
27708008
CYP7_YEASTCPR7genetic
27708008
MOG1_YEASTMOG1genetic
27708008
MCM22_YEASTMCM22genetic
27708008
FEN1_YEASTRAD27genetic
27708008
SIC1_YEASTSIC1genetic
27708008
SWI6_YEASTSWI6genetic
27708008
PFD6_YEASTYKE2genetic
27708008
CTF3_YEASTCTF3genetic
27708008
PPZ1_YEASTPPZ1genetic
27708008
NU188_YEASTNUP188genetic
27708008
CSM3_YEASTCSM3genetic
27708008
CTF18_YEASTCTF18genetic
27708008
OCA2_YEASTOCA2genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
PFD4_YEASTGIM3genetic
27708008
2A5D_YEASTRTS1genetic
27708008
BUB3_YEASTBUB3genetic
27708008
ASE1_YEASTASE1genetic
27708008
ELG1_YEASTELG1genetic
27708008
RS10A_YEASTRPS10Agenetic
27708008
CHL1_YEASTCHL1genetic
27708008
IRC15_YEASTIRC15genetic
27708008
CTF19_YEASTCTF19genetic
27708008
TBCC_YEASTCIN2genetic
27708008
MCM16_YEASTMCM16genetic
27708008
CG22_YEASTCLB2genetic
27708008
CTF4_YEASTCTF4genetic
27708008
KAR3_YEASTKAR3genetic
27708008
SCC4_YEASTSCC4physical
26354421
SCC4_YEASTSCC4physical
25173104
SCC1_YEASTMCD1physical
25748820

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SCC2_YEAST

loading...

Related Literatures of Post-Translational Modification

TOP