| UniProt ID | NAA25_YEAST | |
|---|---|---|
| UniProt AC | Q12387 | |
| Protein Name | N-terminal acetyltransferase B complex subunit MDM20 | |
| Gene Name | MDM20 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 796 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met. NatB acetylates TPM1 protein and regulates tropomyocin-actin interactions. MDM20 is required for mitochondrial inheritance during budding and together with TPM1, is essential for the integrity and assembly of actin cables. Genetically interacts with CIN8.. | |
| Protein Sequence | MSDKIQEEILGLVSRSNFKQCYAKLGQLQKQFPNALYFKILETYVKFKQSPGKFDYNKLLEEPYGLKGTTITGDTRSLEFLHNFFVELGKYDEALHVYERGNFKFPSYELSYHWFMKALEDSNYNQMSKASLQLAKYSDSGNLPKRAYYFWNAISILAVSRFQENTLSDPKKILLSRLARQSLLDLKPFQNVQEIIVYCLVLDELFPQSREISEEIVAITFANFDTSVNLYLKNFILKHTKLLNSPQKLFEVCSKLIEKGLDDYELITNLIDAAYKLSKSKDEVKQWIDENLGDSRNTRLARLKLDIMYTDSVSESSLSYYLSKYHNKPCCSIDLNHYSGHINIDMLKSIMSKYDPEDKDLIHHCNILELGLIGSDSINNYNKFKGTLEKKSVTDYSSCSTFLLEIVKDKCKKTNPELKDVLLCITILENYQAKDPHNFDTMCWLIVLYMYLGLVPDAYFHFINLKIKNVQTDSLDYMIFSRFSTLFPNKQSDFYSKTFHEHNNLYDTSLANLPRYIQVAFERNSYSKILGMLEMRDKLMKSYTRWTKTLENLQFSRLCNDKRGHLLQKLHEDWRSLEMTQSVSFSDNRDFSILDENFAQFLNRGKILEYANLNEESIFLTLIRELIIEALPNGEKTEQISALLKKLPSINLEELLNNNLTEVESASFLIFFEIYENNGKNLHDLISRLMKVPINAKQNWMVSHTYLTKMATLKTLDSLKRIKDKEIQKLIKNSLKELRSCCDDVFKGYSKALVQAYEELKKDECGNLLKELDVKAENVKNIKNSLLGIQKSVRNL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSDKIQEEI ------CCHHHHHHH | 47.84 | 22814378 | |
| 43 | Phosphorylation | LYFKILETYVKFKQS HHHHHHHHHHHHCCC | 30.12 | 19795423 | |
| 44 | Phosphorylation | YFKILETYVKFKQSP HHHHHHHHHHHCCCC | 7.71 | 19823750 | |
| 58 | Acetylation | PGKFDYNKLLEEPYG CCCCCHHHHHCCCCC | 48.50 | 24489116 | |
| 67 | Ubiquitination | LEEPYGLKGTTITGD HCCCCCCCCCEECCC | 50.26 | 23749301 | |
| 129 | Ubiquitination | SNYNQMSKASLQLAK CCHHHHCHHHHHHHH | 36.33 | 23749301 | |
| 136 | Acetylation | KASLQLAKYSDSGNL HHHHHHHHHCCCCCC | 54.61 | 24489116 | |
| 160 | Phosphorylation | AISILAVSRFQENTL HHHHHHHHHCCCCCC | 23.05 | 29650682 | |
| 264 | Phosphorylation | IEKGLDDYELITNLI HHCCCCHHHHHHHHH | 16.58 | 22369663 | |
| 268 | Phosphorylation | LDDYELITNLIDAAY CCHHHHHHHHHHHHH | 36.28 | 22369663 | |
| 275 | Phosphorylation | TNLIDAAYKLSKSKD HHHHHHHHHHHCCHH | 17.74 | 22369663 | |
| 278 | Phosphorylation | IDAAYKLSKSKDEVK HHHHHHHHCCHHHHH | 30.63 | 22369663 | |
| 281 | Acetylation | AYKLSKSKDEVKQWI HHHHHCCHHHHHHHH | 62.74 | 24489116 | |
| 285 | Acetylation | SKSKDEVKQWIDENL HCCHHHHHHHHHHHC | 37.56 | 24489116 | |
| 352 | Phosphorylation | DMLKSIMSKYDPEDK HHHHHHHHHCCCCCC | 26.79 | 28889911 | |
| 385 | Acetylation | INNYNKFKGTLEKKS HCCCHHCCCEECCCC | 53.23 | 25381059 | |
| 543 | Phosphorylation | RDKLMKSYTRWTKTL HHHHHHHHHHHHHHH | 8.53 | 27017623 | |
| 732 | Acetylation | KEIQKLIKNSLKELR HHHHHHHHHHHHHHH | 51.42 | 25381059 | |
| 791 | Acetylation | NSLLGIQKSVRNL-- HHHHHHHHHHHCC-- | 49.34 | 22865919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NAA25_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NAA25_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NAA25_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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