DPH6_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DPH6_YEAST
• UniProt AC: Q12429
• Protein Name: Diphthine--ammonia ligase
• Gene Name: DPH6
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 685
• Subcellular Localization: Cytoplasm .
• Protein Description: Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EFT1 or EFT2) to diphthamide..
• Protein Sequence: MKFIALISGGKDSFYNIFHCLKNNHELIALGNIYPKESEEQELDSFMFQTVGHDLIDYYSKCIGVPLFRRSILRNTSNNVELNYTATQDDEIEELFELLRTVKDKIPDLEAVSVGAILSSYQRTRVENVCSRLGLVVLSYLWQRDQAELMGEMCLMSKDVNNVENDTNSGNKFDARIIKVAAIGLNEKHLGMSLPMMQPVLQKLNQLYQVHICGEGGEFETMVLDAPFFQHGYLELIDIVKCSDGEVHNARLKVKFQPRNLSKSFLLNQLDQLPVPSIFGNNWQDLTQNLPKQQAKTGEQRFENHMSNALPQTTINKTNDKLYISNLQSRKSETVEKQSEDIFTELADILHSNQIPRNHILSASLLIRDMSNFGKINKIYNEFLDLSKYGPLPPSRACVGSKCLPEDCHVQLSVVVDVKNTGKEKINKNKGGLHVQGRSYWAPCNIGPYSQSTWLNDDANQVSFISGQIGLVPQSMEILGTPLTDQIVLALQHFDTLCETIGAQEKLLMTCYISDESVLDSVIKTWAFYCSNMNHRSDLWMDKSDDVEKCLVLVKISELPRGAVAEFGGVTCKRLIVDDNDSDKKEREENDDVSTVFQKLNLNIEGFHNTTVSAFGYNRNFITGFVDSREELELILEKTPKSAQITLYYNPKEIITFHHHIGYYPVEKLFDYRGKEHRFGLHIRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
172	Ubiquitination	NDTNSGNKFDARIIK CCCCCCCCHHHHHHH		23749301
582	Phosphorylation	LIVDDNDSDKKEREE EEECCCCCCHHHHHH		22369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DPH6_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DPH6_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DPH6_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ALDH2_YEAST	ALD2	physical	16554755
EF2_YEAST	EFT2	physical	23468660
ATC3_YEAST	DRS2	genetic	27708008
RS8A_YEAST	RPS8A	genetic	27708008
RS8B_YEAST	RPS8A	genetic	27708008
RLA4_YEAST	RPP2B	genetic	27708008
EF2_YEAST	EFT2	genetic	27708008
TFS2_YEAST	DST1	genetic	27708008
RS27B_YEAST	RPS27B	genetic	27708008
CYP7_YEAST	CPR7	genetic	27708008
SST2_YEAST	SST2	genetic	27708008
SRC1_YEAST	SRC1	genetic	27708008
GGPPS_YEAST	BTS1	genetic	27708008
AXL1_YEAST	AXL1	genetic	27708008
PMP1_YEAST	PMP1	physical	26404137

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.