dbPTM

NDC1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NDC1_YEAST
UniProt AC	P32500
Protein Name	Nucleoporin NDC1
Gene Name	NDC1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	655
Subcellular Localization	Nucleus, nuclear pore complex. Nucleus membrane Multi-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Central core structure of the nuclear pore complex. Spindle pole body, central plaque.
Protein Description	Functions as a component of the nuclear pore complex (NPC) and the spindle pole body (SPB), probably by playing a key role in de novo assembly and insertion of both structures in the nuclear envelope. In SPB duplication NDC1 is required for the insertion of the cytoplasmic side of the SPB in the nuclear envelope, thus allowing for the assembly of the nucleoplasmic SPB side. NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors..
Protein Sequence	MIQTPRELLNPRYTYHTIFSDVCKTRFNHLVTRLFFICSIIQTVVISLLALPHSPLWELALAFIPNILALNLVSLLIIVTRKNYMHVKNFGFANSLTFILGQLLSVKFLVYQGVYSMGSILLSFVLGVVFGRGGSGWKPYYKLFIWLVVPTIYNLQHHVTDADKLSFNCENFFQAPQDYVLERVKRIMEKSVILSVISMFVLPIFTTVFFSRQKSGLFDSFTNGVLAVTNLLIISCIIFITFEFINIAFDAHMSIGCLHKGKLISNLSSTPMETLLSGLSADKPFTRLTAYQELAYRATSLDPSLRAPIYHSKFRSSSGNTWSLILNECLKTIQINNEKVVQYLRSVQDLGGSATARHKKKVENLDYMYENGKLTSANERLFGNRPSMMAPLRDNGLLDESPNRLRVRTDDSVLLNRGNKKRHRSSYYDNDLDETTQTFNGSIFTHETTFMTAMRLMLKKLKNSIMSFIFPSYAERQSSDESDNYRLLPNGSNKAQISIIDIWSISKKRQAEKLVPLPICHANSVVALTGLLIRSKTEDPKGGIIASVGDILKTLERSICALGEFADWDPESMAYTAFQTQRTAQDRVQQDSEDEDSMKDTTDMISVLYQLSTSAFMEIVLEYNVALNDVYLDADVAKLANWFLEVYASGNPNAT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MIQTPRELLNP ----CCCCHHHHHCC	17.25	21440633
323	Phosphorylation	SSSGNTWSLILNECL CCCCCHHHHHHHHHH	11.95	25704821
353	Phosphorylation	SVQDLGGSATARHKK HHHHHCCCCCHHHHH	22.20	23749301
373	Acetylation	DYMYENGKLTSANER HHHHHCCCCCCHHHH	61.24	24489116
401	Phosphorylation	DNGLLDESPNRLRVR CCCCCCCCCCCEEEC	27.43	25533186
409	Phosphorylation	PNRLRVRTDDSVLLN CCCEEECCCCCEEEC	41.10	28889911
412	Phosphorylation	LRVRTDDSVLLNRGN EEECCCCCEEECCCC	19.92	25704821
464	Phosphorylation	MLKKLKNSIMSFIFP HHHHHHHHHHHHHCH	20.34	27017623
467	Phosphorylation	KLKNSIMSFIFPSYA HHHHHHHHHHCHHHH	17.33	27017623
541	Acetylation	RSKTEDPKGGIIASV HCCCCCCCCCEEEEH	80.32	24489116
592	Phosphorylation	QDRVQQDSEDEDSMK HHHHHCCCCCCCHHH	42.48	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NDC1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NDC1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NDC1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUP59_YEAST	ASM4	physical	10688190
NUP53_YEAST	NUP53	physical	10688190
CUE1_YEAST	CUE1	genetic	12399372
DYHC_YEAST	DYN1	genetic	11071919
PO152_YEAST	POM152	genetic	9864355
UBC6_YEAST	UBC6	genetic	12399372
UBC7_YEAST	UBC7	genetic	12399372
NIC96_YEAST	NIC96	genetic	15075274
MPS2_YEAST	MPS2	genetic	16436507
NBP1_YEAST	NBP1	genetic	16436507
NBP1_YEAST	NBP1	physical	16436507
POM34_YEAST	POM34	genetic	16682526
NUP53_YEAST	NUP53	physical	11283351
UBI4P_YEAST	UBI4	genetic	12399372
IMB1_YEAST	KAP95	physical	17897934
PIS_YEAST	PIS1	physical	18467557
NU170_YEAST	NUP170	physical	19414609
NU157_YEAST	NUP157	physical	19414609
PO152_YEAST	POM152	physical	19414609
NUP59_YEAST	ASM4	physical	19414609
POM34_YEAST	POM34	physical	19414609
MPS3_YEAST	MPS3	physical	19414609
NUP53_YEAST	NUP53	physical	19414609
POM34_YEAST	POM34	genetic	19571182
AGC1_YEAST	AGC1	physical	16093310
POM33_YEAST	POM33	genetic	20498018
PER33_YEAST	PER33	genetic	20498018
NU192_YEAST	NUP192	physical	18046405
NU170_YEAST	NUP170	physical	18046405
PO152_YEAST	POM152	physical	18046405
NUP59_YEAST	ASM4	physical	18046405
NU188_YEAST	NUP188	physical	18046405
NU159_YEAST	NUP159	physical	18046405
NSP1_YEAST	NSP1	physical	18046405
NIC96_YEAST	NIC96	physical	18046405
NUP82_YEAST	NUP82	physical	18046405
NUP84_YEAST	NUP84	physical	18046405
NUP53_YEAST	NUP53	physical	18046405
KPYK1_YEAST	CDC19	physical	18046405
EF3A_YEAST	YEF3	physical	18046405
RTN1_YEAST	RTN1	physical	22798490
SSB1_YEAST	SSB1	physical	22940862
NBP1_YEAST	NBP1	physical	24515347
PO152_YEAST	POM152	physical	24515347
POM34_YEAST	POM34	physical	24515347
MPS3_YEAST	MPS3	physical	24515347
PO152_YEAST	POM152	genetic	24515347
YOP1_YEAST	YOP1	physical	26041935
RTN1_YEAST	RTN1	physical	26041935
BBP1_YEAST	BBP1	physical	28356353

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NDC1_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-401, AND MASSSPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-401, AND MASSSPECTROMETRY.	17563356 [Abstract]