AGC1_YEAST - dbPTM
AGC1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AGC1_YEAST
UniProt AC Q12482
Protein Name Mitochondrial aspartate-glutamate transporter AGC1
Gene Name AGC1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 902
Subcellular Localization Mitochondrion inner membrane
Multi-pass membrane protein .
Protein Description Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids..
Protein Sequence MEQINSNSRKKKQQLEVFKYFASVLTKEDKPISISNGMLDMPTVNSSKLTAGNGKPDTEKLTGELILTYDDFIELISSSKTIYSKFTDHSFNLNQIPKNVFGCIFFAIDEQNKGYLTLNDWFYFNNLLEYDNYHLIILYEFFRKFDVENLKAKQKKELGSSSFNLKAADDRIKSINYGNRFLSFDDLLLNLNQFKDTIRLLHESIDDNFVKDNKLLLDWNDFRFLKFYKCYHENEEYLSLNSLVTILQNDLKNEKIFIGFDRLAQMDSQGHRLALSKNQLTYLLRLFYSHRVSADIFSSLNLSNTELLKADNNSIPYNVFKDIFYLFQNFDLLNQIFHKYVTENNLNEQDIREQIVTKNDFMTVLNAQYNKVNNIIEFSPSQINLLFSIVANSKENRRLRKRNQDRDDELLNDHHYDSDIDFFIHNEYLHGVSRSRKNLESFNDYYHDLSDGFDQDSGVKKASKASTGLFESVFGGKKDKATMRSDLTIEDFMKILNPNYLNDLVHQMELQKNQNESLYINYYFYPIFDSLYNFSLGSIAGCIGATVVYPIDFIKTRMQAQRSLAQYKNSIDCLLKIISREGIKGLYSGLGPQLIGVAPEKAIKLTVNDFMRNRLTDKNGKLSLFPEIISGASAGACQVIFTNPLEIVKIRLQVQSDYVGENIQQANETATQIVKKLGLRGLYNGVAACLMRDVPFSAIYFPTYAHLKKDLFDFDPNDKTKRNRLKTWELLTAGAIAGMPAAFLTTPFDVIKTRLQIDPRKGETKYNGIFHAIRTILKEESFRSFFKGGGARVLRSSPQFGFTLAAYELFKGFIPSPDNKLKSREGRKRFCIDDDAGNEETVVHSNGELPQQKFYSDDRKHANYYYKSCQIAKTFIDLDNNFSRFDSSVYKNFQEHLRSING
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MEQINSNSRKKKQ
--CCCCCCCHHHHHH		37.5019795423
8PhosphorylationMEQINSNSRKKKQQL
CCCCCCCHHHHHHHH		45.3519795423
363PhosphorylationVTKNDFMTVLNAQYN
CCHHHHHHHHHHHHH		23.1025521595
450PhosphorylationNDYYHDLSDGFDQDS
HHHHHHCCCCCCCCC		41.5727017623
606PhosphorylationPEKAIKLTVNDFMRN
CHHHHCCCHHHHHHH		16.5619795423
616PhosphorylationDFMRNRLTDKNGKLS
HHHHHCCCCCCCCCC		41.5119795423
868PhosphorylationHANYYYKSCQIAKTF
HHHHHHHHHHHHHEE		8.6419779198
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AGC1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AGC1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AGC1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YOR1_YEASTYOR1physical
16093310
MOB2_YEASTMOB2genetic
27708008
PRP19_YEASTPRP19genetic
27708008
MCM1_YEASTMCM1genetic
27708008
MAK16_YEASTMAK16genetic
27708008
CDC15_YEASTCDC15genetic
27708008
RFC5_YEASTRFC5genetic
27708008
CALM_YEASTCMD1genetic
27708008
MAK5_YEASTMAK5genetic
27708008
CDC10_YEASTCDC10genetic
27708008
PRS4_YEASTRPT2genetic
27708008
APC11_YEASTAPC11genetic
27708008
CDC7_YEASTCDC7genetic
27708008
ARP2_YEASTARP2genetic
27708008
CDC48_YEASTCDC48genetic
27708008
GLE1_YEASTGLE1genetic
27708008
CDC13_YEASTCDC13genetic
27708008
SLU7_YEASTSLU7genetic
27708008
CAB5_YEASTCAB5genetic
27708008
SNU56_YEASTSNU56genetic
27708008
SP110_YEASTSPC110genetic
27708008
GPI17_YEASTGPI17genetic
27708008
UTP6_YEASTUTP6genetic
27708008
TSC11_YEASTTSC11genetic
27708008
RSP5_YEASTRSP5genetic
27708008
CDC4_YEASTCDC4genetic
27708008
GNA1_YEASTGNA1genetic
27708008
ACT_YEASTACT1genetic
27708008
CDC14_YEASTCDC14genetic
27708008
PSA1_YEASTSCL1genetic
27708008
PRS8_YEASTRPT6genetic
27708008
RCC1_YEASTSRM1genetic
27708008
CDC20_YEASTCDC20genetic
27708008
SWC4_YEASTSWC4genetic
27708008
TEL2_YEASTTEL2genetic
27708008
NUP57_YEASTNUP57genetic
27708008
TIM44_YEASTTIM44genetic
27708008
MET30_YEASTMET30genetic
27708008
ATC7_YEASTNEO1genetic
27708008
ARPC5_YEASTARC15genetic
27708008
OST1_YEASTOST1genetic
27708008
HACD_YEASTPHS1genetic
27708008
KRE9_YEASTKRE9genetic
27708008
SWD2_YEASTSWD2genetic
27708008
GFA1_YEASTGFA1genetic
27708008
HYM1_YEASTHYM1genetic
27708008
CD123_YEASTCDC123genetic
27708008
CDC3_YEASTCDC3genetic
27708008
TAF4_YEASTTAF4genetic
27708008
DPOA_YEASTPOL1genetic
27708008
NUF2_YEASTNUF2genetic
27708008
TPT1_YEASTTPT1genetic
27708008
HRP1_YEASTHRP1genetic
27708008
XRN2_YEASTRAT1genetic
27708008
SYA_YEASTALA1genetic
27708008
SYLC_YEASTCDC60genetic
27708008
MEX67_YEASTMEX67genetic
27708008
ORC4_YEASTORC4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AGC1_YEAST

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Related Literatures of Post-Translational Modification

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