RTP1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RTP1_YEAST
• UniProt AC: Q12751
• Protein Name: RNA polymerase II assembly factor RTP1 {ECO:0000305|PubMed:23438601}
• Gene Name: RTP1 {ECO:0000303|PubMed:23438601}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 981
• Subcellular Localization: Cytoplasm .
• Protein Description: Required for the cytoplasmic assembly and the nuclear import of RNA polymerase II. May facilitate the starting interaction between RNA polymerase II subunits RPB2 and RPB3 and the subsequent interaction of the resulting complex with subunit RPB1. May also participate in the transport of RNA polymerase II through the nuclear pore complex..
• Protein Sequence: MNEDKEQKINIHDILNTRPKLTKKTALDVFFEDLDDNVITPINEYVLDSGSSSSSSIYQALKCSNNNEFVAVLLQKFQNLHIHVLEQQRRLIESKSDLLPISLHDMKYVDELINLLIIHGIDANLSPTMKIPFDSKRINTFKKGQKSAEYETPRWHTINNDTLSQVITVFYNVLTSERSSDYLREIISKGSAYANILLGLIVLHLQLPNRYSSQMITNLEDTQETYTLFGVYTLLVETIQDEKVREPILSKLTTLTLRRPENGLISLIDFVLGVRDAEDIDIEKFNRIYQILMSKPKTMTNLQYLTELFKQIYDGLTFVNRPILVTCLNGLILKFYLRNKRIVNDFLFKKVRSIIFNSPLTDHTAKELNDVINVLISLSKNSSSDLLNDLVTSCPDEDGTTPGQFFLYVWIYALFLKKNQKLDPLEINKLSISDNKSTDSIHFPEQSSSKYYEVVLSLLKSLIVITENFQYLNVLSLNLLNFEHEKWKYLIDLDTQLPYISVKNTDMAELFFEKGSKNSQISEFLQDMDLSIELFMEFLVLLNDEEQSKTLFLDILKRWVHHTKKSEKRSSDNHSGMPSVTDNALILMDLKLLECMNNRFKTKIVNKPKDVLIVIDQLIDVVQEKDETIQEVEADSDDEVEEGEETEELDPNENSSYKIILQLLSTVLSESSSSILLQNSYILKSISRKLQSFNTNASEIDALLASIDNILINGHTTERNDNIEIEMDEERLDKAITSLHDPLVPIKSYGLTELRHLAEKKSPVISLEKVLQIHLDYLKNMDPFIYLNVIKGLTTLCELEPETILPLLAEFYANKKKKNRLDDVLKVGEVFINYIQRQNELFQGKLAYLIIDTCLSIVRPNDSKPLDNRWRMSSMSILGMCLQINARGVSDRIRDMLDCVFGILQLEQPQNHLKDKDDSFLMRRSAVHLIHDLLYSTGFDLLPFEYNYDKLKTLLSYVRDQDEDYMVCEQIDKLLTVLDSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
636	Phosphorylation	IQEVEADSDDEVEEG CEEECCCCCCCCCCC		21551504
919	Phosphorylation	HLKDKDDSFLMRRSA HCCCCCCCHHHHHHH		27017623
936	Phosphorylation	LIHDLLYSTGFDLLP HHHHHHHHCCCCCCC		27017623
946	Phosphorylation	FDLLPFEYNYDKLKT CCCCCCCCCHHHHHH		27017623
948	Phosphorylation	LLPFEYNYDKLKTLL CCCCCCCHHHHHHHH		27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RTP1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RTP1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RTP1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IWR1_YEAST	IWR1	genetic	23438601
NU100_YEAST	NUP100	physical	23438601
NU116_YEAST	NUP116	physical	23438601
RPB2_YEAST	RPB2	physical	23438601
RPB3_YEAST	RPB3	physical	23438601
RPB1_YEAST	RPO21	physical	23438601
RUVB2_YEAST	RVB2	physical	23438601
PIH1_YEAST	PIH1	physical	23438601

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.