YRB2_YEAST - dbPTM
YRB2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YRB2_YEAST
UniProt AC P40517
Protein Name Ran-specific GTPase-activating protein 2
Gene Name YRB2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 327
Subcellular Localization Nucleus .
Protein Description Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1..
Protein Sequence MSETNGGNAARENSEVKQTAVENPIDKLDGTPKRPREKDQDEQAEETSDKSEAPNKNDEEKKEEGKKDQEPSHKKIKVDDGKTVESGIVEDDKKEDKFVFGAASKFGTGFGVAKKDTKDGDATTSTESLPASDSKTKKPFAFGSGLSFGSGFNILKNKTENNSESEKKATDVDKDKVHSGSEQLANASEDTKDKPKPLKLQKQEVKSGEESEECIYQVNAKLYQLSNIKEGWKERGVGIIKINKSKDDVEKTRIVMRSRGILKVILNIQLVKGFTVQKGFTGSLQSEKFIRLLAVDDNGDPAQYAIKTGKKETTDELYNIIVKSVPK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSETNGGNA
------CCCCCCCCH		53.8022369663
4Phosphorylation----MSETNGGNAAR
----CCCCCCCCHHH		31.6822369663
14PhosphorylationGNAARENSEVKQTAV
CCHHHCCCHHHHHHH		38.7322369663
17AcetylationARENSEVKQTAVENP
HHCCCHHHHHHHHCC		37.5724489116
19PhosphorylationENSEVKQTAVENPID
CCCHHHHHHHHCCHH		27.2719795423
27AcetylationAVENPIDKLDGTPKR
HHHCCHHHCCCCCCC		49.5524489116
31PhosphorylationPIDKLDGTPKRPREK
CHHHCCCCCCCCCCC		25.8822369663
47PhosphorylationQDEQAEETSDKSEAP
HHHHHHHHCCCCCCC		33.4619795423
48PhosphorylationDEQAEETSDKSEAPN
HHHHHHHCCCCCCCC		46.4529136822
51PhosphorylationAEETSDKSEAPNKND
HHHHCCCCCCCCCCH		43.9421551504
74AcetylationKDQEPSHKKIKVDDG
CCCCCCCCCEECCCC		61.6125381059
105AcetylationFVFGAASKFGTGFGV
EEEEHHHHCCCCEEE		42.9825381059
117PhosphorylationFGVAKKDTKDGDATT
EEEEECCCCCCCCCC		39.6619779198
123PhosphorylationDTKDGDATTSTESLP
CCCCCCCCCCCCCCC		26.4822369663
124PhosphorylationTKDGDATTSTESLPA
CCCCCCCCCCCCCCC		35.0622369663
125PhosphorylationKDGDATTSTESLPAS
CCCCCCCCCCCCCCC		26.3122369663
126PhosphorylationDGDATTSTESLPASD
CCCCCCCCCCCCCCC		27.7422369663
128PhosphorylationDATTSTESLPASDSK
CCCCCCCCCCCCCCC		39.4822369663
132PhosphorylationSTESLPASDSKTKKP
CCCCCCCCCCCCCCC		40.2429136822
144PhosphorylationKKPFAFGSGLSFGSG
CCCCCCCCCCCCCCC		30.0624961812
147PhosphorylationFAFGSGLSFGSGFNI
CCCCCCCCCCCCCHH		30.9624961812
150PhosphorylationGSGLSFGSGFNILKN
CCCCCCCCCCHHHCC		37.9021440633
170PhosphorylationSESEKKATDVDKDKV
CHHHHHCCCCCHHHC		45.4928889911
179PhosphorylationVDKDKVHSGSEQLAN
CCHHHCCCCHHHHHC		47.1822369663
181PhosphorylationKDKVHSGSEQLANAS
HHHCCCCHHHHHCCC		25.7822369663
188PhosphorylationSEQLANASEDTKDKP
HHHHHCCCCCCCCCC		35.4922890988
191PhosphorylationLANASEDTKDKPKPL
HHCCCCCCCCCCCCC		36.7722890988
207PhosphorylationLQKQEVKSGEESEEC
HHHEEHHCCCCCHHH		57.5223749301
216PhosphorylationEESEECIYQVNAKLY
CCCHHHHHHHHHHHH		20.3327017623
221AcetylationCIYQVNAKLYQLSNI
HHHHHHHHHHHHHCC		42.3924489116
229AcetylationLYQLSNIKEGWKERG
HHHHHCCCHHHHHCC		55.1924489116
288AcetylationTGSLQSEKFIRLLAV
CCCCCCHHEEEEEEE		51.8724489116
307AcetylationDPAQYAIKTGKKETT
CHHHHHHHCCCCCCH		42.9524489116
323AcetylationELYNIIVKSVPK---
HHHHHHHHCCCC---		35.0124489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YRB2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YRB2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YRB2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
XPO1_YEASTCRM1physical
11805837
SYSM_YEASTDIA4physical
11805837
KPR5_YEASTPRS5physical
11805837
XPO1_YEASTCRM1physical
9636166
RCC1_YEASTSRM1physical
9395535
GSP1_YEASTGSP1physical
9121474
GSP1_YEASTGSP1physical
9395535
XPO1_YEASTCRM1genetic
10050047
GSP1_YEASTGSP1genetic
10050047
RCC1_YEASTSRM1genetic
9395535
RNA1_YEASTRNA1genetic
9121474
RRP1_YEASTRRP1physical
16554755
CYPD_YEASTCPR5physical
16554755
RV167_YEASTRVS167physical
16554755
RAD4_YEASTRAD4physical
16554755
SYEC_YEASTGUS1physical
16554755
SSZ1_YEASTSSZ1physical
16554755
CSK21_YEASTCKA1physical
16554755
SC160_YEASTSCP160physical
16554755
DEF1_YEASTDEF1physical
16554755
NAP1_YEASTNAP1physical
16554755
EIF3C_YEASTNIP1physical
16554755
END3_YEASTEND3physical
16554755
GTR1_YEASTGTR1physical
16143306
GTR1_YEASTGTR1genetic
16143306
GTR2_YEASTGTR2genetic
16143306
LTV1_YEASTLTV1genetic
16888326
SAC3_YEASTSAC3genetic
19061648
PTH2_YEASTPTH2genetic
19061648
MRH4_YEASTMRH4genetic
19061648
MRT4_YEASTMRT4genetic
19061648
SSBP1_YEASTSBP1genetic
19061648
XPO1_YEASTCRM1physical
25437554
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YRB2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; THR-31; SER-125;SER-179 AND SER-181, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; THR-31; SER-179 ANDSER-181, AND MASS SPECTROMETRY.

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