SIS2_YEAST - dbPTM
SIS2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SIS2_YEAST
UniProt AC P36024
Protein Name Phosphopantothenoylcysteine decarboxylase subunit SIS2
Gene Name SIS2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 562
Subcellular Localization Nucleus. Cytoplasm.
Protein Description Component of the phosphopantothenoylcysteine decarboxylase (PPCDC) involved in the coenzyme A synthesis. Acts as an inhibitory subunit of protein phosphatase PPZ1, which is involved in many cellular processes such as G1-S transition or salt tolerance. Also modulates the expression of the ENA1 ATPase..
Protein Sequence MTAVASTSGKQDADHNQSIECPRFSRGQKEILLDHEDAKGKDSIINSPVSGRQSISPTLSNATTTTTKSIMNATGTSGAVVSNTPEPGLKRVPAVTFSDLKQQQKQDSLTQLKNDSERTKSPNSNPAPVSNSIPGNHAVIPNHTNTSRTTQLSGSPLVNEMKDYDPKKKDSALKIVDTMKPDKIMATSTPISRENNKVTAKAPTSITLRKEDAQDQANNVSGQINVRSTPEETPVKQSVIPSIIPKRENSKNLDPRLPQDDGKLHVLFGATGSLSVFKIKPMIKKLEEIYGRDRISIQVILTQSATQFFEQRYTKKIIKSSEKLNKMSQYESTPATPVTPTPGQCNMAQVVELPPHIQLWTDQDEWDAWKQRTDPVLHIELRRWADILVVAPLTANTLSKIALGLCDNLLTSVIRAWNPSYPILLAPSMVSSTFNSMMTKKQLQTIKEEMSWVTVFKPSEKVMDINGDIGLGGMMDWNEIVNKIVMKLGGYPKNNEEEDDDEDEEEDDDEEEDTEDKNENNNDDDDDDDDDDDDDDDDDDDDDDDDEDEDEAETPGIIDKHQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18PhosphorylationQDADHNQSIECPRFS
CCCCCCCCCCCCCCC		26.1823749301
43PhosphorylationEDAKGKDSIINSPVS
HHHCCCCCCCCCCCC		28.9322369663
47PhosphorylationGKDSIINSPVSGRQS
CCCCCCCCCCCCCCC		19.1022369663
50PhosphorylationSIINSPVSGRQSISP
CCCCCCCCCCCCCCC		31.4822369663
54PhosphorylationSPVSGRQSISPTLSN
CCCCCCCCCCCCCCC		24.5522369663
56PhosphorylationVSGRQSISPTLSNAT
CCCCCCCCCCCCCCC		19.6522369663
58PhosphorylationGRQSISPTLSNATTT
CCCCCCCCCCCCCCC		35.7122369663
60PhosphorylationQSISPTLSNATTTTT
CCCCCCCCCCCCCCC		27.2222369663
63PhosphorylationSPTLSNATTTTTKSI
CCCCCCCCCCCCHHH		29.0022369663
64PhosphorylationPTLSNATTTTTKSIM
CCCCCCCCCCCHHHH		21.5322369663
65PhosphorylationTLSNATTTTTKSIMN
CCCCCCCCCCHHHHH		28.2822369663
66PhosphorylationLSNATTTTTKSIMNA
CCCCCCCCCHHHHHC		30.0922369663
67PhosphorylationSNATTTTTKSIMNAT
CCCCCCCCHHHHHCC		22.2422369663
69PhosphorylationATTTTTKSIMNATGT
CCCCCCHHHHHCCCC		25.6128152593
74PhosphorylationTKSIMNATGTSGAVV
CHHHHHCCCCCCCEE		35.6727017623
76PhosphorylationSIMNATGTSGAVVSN
HHHHCCCCCCCEECC		21.4530377154
77PhosphorylationIMNATGTSGAVVSNT
HHHCCCCCCCEECCC		26.5430377154
82PhosphorylationGTSGAVVSNTPEPGL
CCCCCEECCCCCCCC		28.5222369663
84PhosphorylationSGAVVSNTPEPGLKR
CCCEECCCCCCCCCC		22.8622369663
96PhosphorylationLKRVPAVTFSDLKQQ
CCCCCEEEHHHHHHH		21.3730377154
101AcetylationAVTFSDLKQQQKQDS
EEEHHHHHHHHHHHH		51.5624489116
108PhosphorylationKQQQKQDSLTQLKND
HHHHHHHHHHHHHCH		30.7222369663
110PhosphorylationQQKQDSLTQLKNDSE
HHHHHHHHHHHCHHH		35.4922369663
119PhosphorylationLKNDSERTKSPNSNP
HHCHHHCCCCCCCCC		31.6422369663
121PhosphorylationNDSERTKSPNSNPAP
CHHHCCCCCCCCCCC		28.8022369663
124PhosphorylationERTKSPNSNPAPVSN
HCCCCCCCCCCCCCC		47.8022369663
130PhosphorylationNSNPAPVSNSIPGNH
CCCCCCCCCCCCCCC		24.6522369663
144PhosphorylationHAVIPNHTNTSRTTQ
CCCCCCCCCCCCCEE		47.0021551504
149PhosphorylationNHTNTSRTTQLSGSP
CCCCCCCCEECCCCC		20.7522369663
150PhosphorylationHTNTSRTTQLSGSPL
CCCCCCCEECCCCCC		26.8022369663
153PhosphorylationTSRTTQLSGSPLVNE
CCCCEECCCCCCHHH		27.6622369663
155PhosphorylationRTTQLSGSPLVNEMK
CCEECCCCCCHHHCC		16.2222369663
180AcetylationLKIVDTMKPDKIMAT
CHHHHCCCCCCEEEE		52.7524489116
183AcetylationVDTMKPDKIMATSTP
HHCCCCCCEEEECCC		42.8024489116
187PhosphorylationKPDKIMATSTPISRE
CCCCEEEECCCCCCC		18.7622369663
188PhosphorylationPDKIMATSTPISREN
CCCEEEECCCCCCCC		23.7322369663
189PhosphorylationDKIMATSTPISRENN
CCEEEECCCCCCCCC		21.9322369663
192PhosphorylationMATSTPISRENNKVT
EEECCCCCCCCCEEE		34.4422369663
199PhosphorylationSRENNKVTAKAPTSI
CCCCCEEEEECCCEE		24.8519823750
205PhosphorylationVTAKAPTSITLRKED
EEEECCCEEEEEHHH		16.7121551504
221PhosphorylationQDQANNVSGQINVRS
HHHHHCCCCEEECCC		27.4021440633
228PhosphorylationSGQINVRSTPEETPV
CCEEECCCCCCCCCC		43.9929136822
229PhosphorylationGQINVRSTPEETPVK
CEEECCCCCCCCCCC		24.9329136822
233PhosphorylationVRSTPEETPVKQSVI
CCCCCCCCCCCCHHC		31.5529136822
320PhosphorylationYTKKIIKSSEKLNKM
HHHHHHHCHHHHHHH		33.0629136822
321PhosphorylationTKKIIKSSEKLNKMS
HHHHHHCHHHHHHHH		33.4830377154
421PhosphorylationIRAWNPSYPILLAPS
HHHHCCCCCEEECHH		8.7828132839
491PhosphorylationIVMKLGGYPKNNEEE
HHHHHCCCCCCCCCC		14.8321551504
514PhosphorylationDDDEEEDTEDKNENN
CCCCCCCCCCCCCCC		49.7328889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SIS2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SIS2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SIS2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BCK2_YEASTBCK2genetic
12518319
CG13_YEASTCLN3genetic
12518319
HAL1_YEASTHAL1genetic
9178503
LIC4_YEASTATC1genetic
10102375
NAH1_YEASTNHA1genetic
12804783
NAH1_YEASTNHA1genetic
11382758
SWI4_YEASTSWI4genetic
12518319
VHS1_YEASTVHS1genetic
12518319
VHS2_YEASTVHS2genetic
12518319
VHS3_YEASTVHS3genetic
12518319
PP11_YEASTSIT4genetic
12518319
PPZ1_YEASTPPZ1genetic
9636153
VHS3_YEASTVHS3genetic
15192104
HSP73_YEASTSSA3physical
16554755
RDH54_YEASTRDH54physical
16554755
SWR1_YEASTSWR1physical
16554755
MNS1_YEASTMNS1physical
16554755
TRM2_YEASTTRM2physical
16554755
CSK22_YEASTCKA2physical
16554755
PP2C1_YEASTPTC1genetic
16956380
SODC_YEASTSOD1genetic
17314980
MED3_YEASTPGD1genetic
17314980
PPZ1_YEASTPPZ1physical
18467557
OSTD_YEASTSWP1physical
18467557
PIS_YEASTPIS1physical
18467557
SIS2_YEASTSIS2physical
18467557
CAB3_YEASTCAB3genetic
19915539
TRK1_YEASTTRK1genetic
21143561
PP2A1_YEASTPPH21genetic
12518319
PP2A2_YEASTPPH22genetic
12518319
HAL4_YEASTSAT4genetic
12518319
PTK2_YEASTPTK2genetic
12518319
PP2C2_YEASTPTC2genetic
12518319
NAH1_YEASTNHA1genetic
12518319
YAP7_YEASTYAP7genetic
12518319
VHS3_YEASTVHS3genetic
22124281
PPZ1_YEASTPPZ1physical
22615397
VHS3_YEASTVHS3genetic
23454581
PPZ1_YEASTPPZ1genetic
23454581
FLO8_YEASTFLO8genetic
23454581
FLO11_YEASTFLO11genetic
23454581
TRK2_YEASTTRK2genetic
23454581
SLT2_YEASTSLT2genetic
23962284
ACT_YEASTACT1genetic
27708008
CDC12_YEASTCDC12genetic
27708008
CDC11_YEASTCDC11genetic
27708008
RU1C_YEASTYHC1genetic
27708008
CDC3_YEASTCDC3genetic
27708008
SEC63_YEASTSEC63genetic
27708008
VPS8_YEASTVPS8genetic
27708008
BUD3_YEASTBUD3genetic
27708008
MDM34_YEASTMDM34genetic
27708008
AAR2_YEASTAAR2genetic
27708008
CDC27_YEASTCDC27genetic
27708008
CND2_YEASTBRN1genetic
27708008
TRS20_YEASTTRS20genetic
27708008
RRP42_YEASTRRP42genetic
27708008
ERF3_YEASTSUP35genetic
27708008
NSE3_YEASTNSE3genetic
27708008
RPB7_YEASTRPB7genetic
27708008
MOB2_YEASTMOB2genetic
27708008
YPT1_YEASTYPT1genetic
27708008
CDC14_YEASTCDC14genetic
27708008
PRS8_YEASTRPT6genetic
27708008
CDC20_YEASTCDC20genetic
27708008
MCE1_YEASTCEG1genetic
27708008
ZPR1_YEASTZPR1genetic
27708008
BRL1_YEASTBRL1genetic
27708008
RPF1_YEASTRPF1genetic
27708008
UTP9_YEASTUTP9genetic
27708008
MCM10_YEASTMCM10genetic
27708008
KTHY_YEASTCDC8genetic
27708008
RRN3_YEASTRRN3genetic
27708008
YKT6_YEASTYKT6genetic
27708008
SEC22_YEASTSEC22genetic
27708008
CDC91_YEASTGAB1genetic
27708008
RSE1_YEASTRSE1genetic
27708008
POB3_YEASTPOB3genetic
27708008
TAF4_YEASTTAF4genetic
27708008
VTI1_YEASTVTI1genetic
27708008
RNA1_YEASTRNA1genetic
27708008
DPOA_YEASTPOL1genetic
27708008
PRP2_YEASTPRP2genetic
27708008
APC5_YEASTAPC5genetic
27708008
NSL1_YEASTNSL1genetic
27708008
ARP7_YEASTARP7genetic
27708008
SRO77_YEASTSRO77genetic
27708008
YRO2_YEASTYRO2genetic
27708008
TYDP1_YEASTTDP1genetic
27708008
AP3M_YEASTAPM3genetic
27708008
HAL4_YEASTSAT4genetic
27708008
SNT1_YEASTSNT1genetic
27708008
CSM1_YEASTCSM1genetic
27708008
YCZ1_YEASTYCR101Cgenetic
27708008
GPR1_YEASTGPR1genetic
27708008
ATG9_YEASTATG9genetic
27708008
ARO1_YEASTARO1genetic
27708008
MEI4_YEASTMEI4genetic
27708008
GEP7_YEASTGEP7genetic
27708008
DOG2_YEASTDOG2genetic
27708008
VPS53_YEASTVPS53genetic
27708008
PBS2_YEASTPBS2genetic
27708008
BCA2_YEASTBAT2genetic
27708008
DBR1_YEASTDBR1genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
CSF1_YEASTCSF1genetic
27708008
HOG1_YEASTHOG1genetic
27708008
ELP1_YEASTIKI3genetic
27708008
PRM6_YEASTPRM6genetic
27708008
MSC1_YEASTMSC1genetic
27708008
SCS7_YEASTSCS7genetic
27708008
YNE0_YEASTYNL040Wgenetic
27708008
BRE5_YEASTBRE5genetic
27708008
COQ10_YEASTCOQ10genetic
27708008
2A5D_YEASTRTS1genetic
27708008
VHS3_YEASTVHS3genetic
27708008
TIP41_YEASTTIP41genetic
27708008
CAB3_YEASTCAB3physical
26514574
VHS3_YEASTVHS3physical
26514574
SIS2_YEASTSIS2physical
26514574
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SIS2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47; SER-50; SER-54;SER-56 AND SER-155, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47; SER-50; SER-54 ANDSER-56, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47; SER-50 AND SER-54,AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56, AND MASSSPECTROMETRY.

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