CBK1_YEAST - dbPTM
CBK1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CBK1_YEAST
UniProt AC P53894
Protein Name Serine/threonine-protein kinase CBK1
Gene Name CBK1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 756
Subcellular Localization
Protein Description Protein kinase that seems to play a role in the regulation of cell morphogenesis and proliferation..
Protein Sequence MYNSSTNHHEGAPTSGHGYYMSQQQDQQHQQQQQYANEMNPYQQIPRPPAAGFSSNYMKEQGSHQSLQEHLQRETGNLGSGFTDVPALNYPATPPPHNNYAASNQMINTPPPSMGGLYRHNNNSQSMVQNGNGSGNAQLPQLSPGQYSIESEYNQNLNGSSSSSPFHQPQTLRSNGSYSSGLRSVKSFQRLQQEQENVQVQQQLSQAQQQNSRQQQQQLQYQQQQQQQQQQQHMQIQQQQQQQQQQQQSQSPVQSGFNNGTISNYMYFERRPDLLTKGTQDKAAAVKLKIENFYQSSVKYAIERNERRVELETELTSHNWSEERKSRQLSSLGKKESQFLRLRRTRLSLEDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKLGFIHRDIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPGTYNANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPDDIHISYEAEDLIRRLLTHADQRLGRHGGADEIKSHPFFRGVDWNTIRQVEAPYIPKLSSITDTRFFPTDELENVPDSPAMAQAAKQREQMTKQGGSAPVKEDLPFIGYTYSRFDYLTRKNAL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
63PhosphorylationNYMKEQGSHQSLQEH
HHHHHCCCHHHHHHH		20.3222369663
66PhosphorylationKEQGSHQSLQEHLQR
HHCCCHHHHHHHHHH		26.9622369663
93PhosphorylationPALNYPATPPPHNNY
CCCCCCCCCCCCCCC		31.6528889911
109PhosphorylationASNQMINTPPPSMGG
CCCCCCCCCCCCCCC		26.6723749301
174PhosphorylationHQPQTLRSNGSYSSG
CCCCCHHCCCCCCCC		48.9722369663
177PhosphorylationQTLRSNGSYSSGLRS
CCHHCCCCCCCCCCC		26.5422369663
178PhosphorylationTLRSNGSYSSGLRSV
CHHCCCCCCCCCCCH		14.3021440633
179PhosphorylationLRSNGSYSSGLRSVK
HHCCCCCCCCCCCHH		21.4522369663
180PhosphorylationRSNGSYSSGLRSVKS
HCCCCCCCCCCCHHH		33.3522369663
184PhosphorylationSYSSGLRSVKSFQRL
CCCCCCCCHHHHHHH		38.6522369663
187PhosphorylationSGLRSVKSFQRLQQE
CCCCCHHHHHHHHHH		25.1822369663
205PhosphorylationVQVQQQLSQAQQQNS
HHHHHHHHHHHHHHH		21.0922369663
378PhosphorylationKKDTGKIYAMKTLLK
ECCCCCCHHHHHHHH		12.2527017623
492PhosphorylationIRGHIKLSDFGLSTG
ECCCEEHHHCCCCCC		26.3730377154
524UbiquitinationEATNGISKPGTYNAN
HHCCCCCCCCCCCCC		45.6123749301
532PhosphorylationPGTYNANTTDTANKR
CCCCCCCCCCCCCCC		24.5223749301
538UbiquitinationNTTDTANKRQTMVVD
CCCCCCCCCCEEEEE		43.3423749301
559PhosphorylationSNRQQIQTWRKSRRL
CCHHHHHHHHHHHCH		28.9423749301
570PhosphorylationSRRLMAYSTVGTPDY
HHCHHHHCCCCCCCC		13.6928889911
690AcetylationVEAPYIPKLSSITDT
EECCCCCCCCCCCCC		51.9824489116
693PhosphorylationPYIPKLSSITDTRFF
CCCCCCCCCCCCCCC		39.6930377154
711PhosphorylationELENVPDSPAMAQAA
HHCCCCCCHHHHHHH		14.4220377248
742PhosphorylationEDLPFIGYTYSRFDY
CCCCCCCEECCHHHH		9.5522890988
743PhosphorylationDLPFIGYTYSRFDYL
CCCCCCEECCHHHHH		15.1422890988
744PhosphorylationLPFIGYTYSRFDYLT
CCCCCEECCHHHHHH		6.8622890988
745PhosphorylationPFIGYTYSRFDYLTR
CCCCEECCHHHHHHH		20.7622890988
751PhosphorylationYSRFDYLTRKNAL--
CCHHHHHHHHCCC--		33.1121440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CBK1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CBK1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CBK1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SSD1_YEASTSSD1physical
11805837
SGT2_YEASTSGT2physical
11805837
HSP7E_YEASTECM10physical
11805837
UBP15_YEASTUBP15physical
11805837
PRTB_YEASTPRB1physical
11805837
GAL7_YEASTGAL7physical
11805837
SIS1_YEASTSIS1physical
11805837
TAO3_YEASTTAO3physical
11805837
ARP2_YEASTARP2physical
11805837
MOB2_YEASTMOB2physical
11805837
COPE_YEASTSEC28physical
11805837
VA0D_YEASTVMA6physical
11805837
MOB2_YEASTMOB2physical
12196508
TAO3_YEASTTAO3physical
11854408
LRE1_YEASTLRE1physical
11580836
ACE2_YEASTACE2physical
10970846
LRE1_YEASTLRE1physical
10970846
MOB2_YEASTMOB2physical
10970846
NOT3_YEASTNOT3physical
10970846
SEC2_YEASTSEC2physical
10970846
SSD1_YEASTSSD1physical
10970846
ARB1_YEASTARB1physical
10970846
YO036_YEASTYOL036Wphysical
10970846
CBK1_YEASTCBK1physical
12972564
KIC1_YEASTKIC1physical
12972564
MOB2_YEASTMOB2physical
12972564
SOG2_YEASTSOG2physical
12972564
STE5_YEASTSTE5physical
10411916
STE50_YEASTSTE50physical
10411916
STE20_YEASTSTE20physical
10411916
SIM1_YEASTSIM1genetic
11854408
KAPA_YEASTTPK1genetic
14871942
RAS2_YEASTRAS2genetic
14871942
UBC3_YEASTCDC34genetic
11957109
SSD1_YEASTSSD1genetic
11854408
CCW12_YEASTCCW12genetic
15972461
SIM1_YEASTSIM1genetic
15972461
SRL1_YEASTSRL1genetic
15972461
ZRG8_YEASTZRG8genetic
15972461
SSD1_YEASTSSD1genetic
12454058
BEM1_YEASTBEM1genetic
12454058
BEM2_YEASTBEM2genetic
12454058
BEM4_YEASTBEM4genetic
12454058
BST1_YEASTBST1genetic
12454058
GAS1_YEASTGAS1genetic
12454058
GOSR1_YEASTGOS1genetic
12454058
KRE1_YEASTKRE1genetic
12454058
NBP2_YEASTNBP2genetic
12454058
SAC7_YEASTSAC7genetic
12454058
ACE2_YEASTACE2genetic
15947194
ACE2_YEASTACE2physical
18292088
SEC2_YEASTSEC2physical
18843045
SEC2_YEASTSEC2genetic
18843045
COG1_YEASTCOG1genetic
18843045
YPT6_YEASTYPT6genetic
18843045
SEC16_YEASTSEC16genetic
18843045
MNN1_YEASTMNN1genetic
18843045
MNN4_YEASTMNN4genetic
18843045
MNN9_YEASTMNN9genetic
18843045
PMT1_YEASTPMT1genetic
18843045
PMT3_YEASTPMT3genetic
18843045
KTR1_YEASTKTR1genetic
18843045
KTR2_YEASTKTR2genetic
18843045
ACE2_YEASTACE2physical
18715118
CBK1_YEASTCBK1physical
19345193
BRR1_YEASTBRR1genetic
19546315
MPT5_YEASTMPT5genetic
19546315
SSD1_YEASTSSD1genetic
19962308
RS8A_YEASTRPS8Agenetic
20093466
RS8B_YEASTRPS8Agenetic
20093466
THRC_YEASTTHR4genetic
20093466
RT103_YEASTRTT103genetic
20093466
RPOM_YEASTRPO41genetic
20093466
BLM10_YEASTBLM10genetic
20093466
VPS35_YEASTVPS35genetic
20093466
HOG1_YEASTHOG1genetic
20093466
LIPB_YEASTLIP2genetic
20093466
SST2_YEASTSST2genetic
20093466
MSC1_YEASTMSC1genetic
20093466
VPS71_YEASTVPS71genetic
20093466
SUB1_YEASTSUB1genetic
20093466
INO4_YEASTINO4genetic
20093466
SIN3_YEASTSIN3genetic
20093466
NEW1_YEASTNEW1genetic
20093466
CTI6_YEASTCTI6genetic
20093466
LGE1_YEASTLGE1genetic
20093466
NAA30_YEASTMAK3genetic
20093466
BUD4_YEASTBUD4genetic
15947194
ACE2_YEASTACE2physical
20489023
CDC14_YEASTCDC14physical
20489023
IF4E_YEASTCDC33physical
20489023
EAP1_YEASTEAP1physical
20489023
FIR1_YEASTFIR1physical
20489023
KIN2_YEASTKIN2physical
20489023
MOB2_YEASTMOB2physical
20489023
MRP8_YEASTMRP8physical
20489023
PABP_YEASTPAB1physical
20489023
SLM1_YEASTSLM1physical
20489023
STE20_YEASTSTE20physical
20489023
TAO3_YEASTTAO3physical
20489023
IF4F1_YEASTTIF4631physical
20489023
IF4F2_YEASTTIF4632physical
20489023
YO036_YEASTYOL036Wphysical
20489023
ZRG8_YEASTZRG8physical
20489023
FKS2_YEASTGSC2physical
21118957
HLR1_YEASTHLR1physical
21118957
LRE1_YEASTLRE1physical
21118957
KIN1_YEASTKIN1physical
21118957
KIN2_YEASTKIN2physical
21118957
CBK1_YEASTCBK1physical
21118957
TAO3_YEASTTAO3physical
21118957
PAL1_YEASTPAL1physical
21118957
CDK1_YEASTCDC28physical
21118957
SVL3_YEASTSVL3physical
21118957
AST1_YEASTAST1physical
21460040
ARB1_YEASTARB1physical
21460040
NBA1_YEASTNBA1physical
21460040
SNL1_YEASTSNL1physical
21460040
SSD1_YEASTSSD1physical
21460040
HSP79_YEASTSSE2physical
21460040
RNZ_YEASTTRZ1physical
21460040
WWM1_YEASTWWM1physical
21460040
YD132_YEASTYDR132Cphysical
21460040
RGI1_YEASTRGI1physical
21460040
YPT32_YEASTYPT32physical
21460040
SSD1_YEASTSSD1genetic
21762218
BCK2_YEASTBCK2genetic
22031291
RPH1_YEASTRPH1genetic
22031291
LRE1_YEASTLRE1physical
23954433
KIC1_YEASTKIC1physical
23954433
TAO3_YEASTTAO3physical
23954433
HYM1_YEASTHYM1physical
23954433
ACE2_YEASTACE2physical
23954433
HOG1_YEASTHOG1genetic
22282571
MOB2_YEASTMOB2physical
25966461
ACE2_YEASTACE2physical
25966461
SSD1_YEASTSSD1physical
25966461
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CBK1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63; SER-66; THR-109 ANDSER-177, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63; SER-66 AND SER-187,AND MASS SPECTROMETRY.

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