KIC1_YEAST - dbPTM
KIC1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KIC1_YEAST
UniProt AC P38692
Protein Name Serine/threonine-protein kinase KIC1
Gene Name KIC1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1080
Subcellular Localization
Protein Description Protein kinase involved in morphogenesis and cell integrity..
Protein Sequence MTTKPQNSKQGLAEGEMDVSSLFKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRPGKIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRLEDRSYSTSLKEFIALCLDEDPKERLSADDLLKSKFIRAHKATPTSILKELISRYLLFRDKNKNKYKIEGSIPENEPSKPSEAPKPSQNGGGDEAQKSIASNDNEIKRVNEGDVEMKWDFDSLSSSDYIIENNINLDALAEDNNEWATAQHDLFNYAYPDEDSYYFDPTSHNTRPFVYQGTTIGKGYPGTIAQNSTLNAPVTNNYTNSKYPSKMVAGTTNTSGTHTAGPMTSSKRLESKAPKQLLELFEDNEIITAENDVNTEAPKISKSISSLNAGNSSRDDFIPSISNEVNGNINNNKMRPHLPPLSSGNNYYSQSTPALPLLQTKFNKTSKGPPTSGLTTAPTSIEIEIPEELPNSALPTPASADPVLIPSTKARSSTVTAGTPSSSSSIQYKSPSNVPRRLTVSNNRPEHCPSTITNQKLGSAVASNSGISSTPNNSNNYNNNTDSENSRGSSGSNTANSTQMGITNPGNVTKLSTHKASSPSRPLFGVGTSPNRKPAGSPTQNIGHNSTHTNLAPPPTMKPMANSKDNKDILLQPLNSIPSSSTLNTISGNSSNNLTSSNYFSNEKEGSRVNGDFKRNNPNLKLQMPLPTPVVRNKLLDPNTATSQNNNGMPGSAGISTNENINQFGFNTSSASNIPVSMTPISEKHIDFGGKIKRSQSISNRKNSSASEHPLNILGSSVSGNVSGIGNNNVGSNNNSGPNNSVPLSANTGNTTIKANSTTIATSSSAAASTTAPISQQTIPSGTQFNHILSSAATAANSVNSLGFGMCPPPQSLQMEMFLDLESFLPGKQRRVDRKPQVLKELENLLQMFEEGLPCIEHALKEQLISTPIKDNEH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
178PhosphorylationQTSLRRQTMAGTPYW
CHHHHHHHCCCCCCC		13.7427017623
182PhosphorylationRRQTMAGTPYWMAPE
HHHHCCCCCCCCCCH		12.0327017623
196PhosphorylationEVIMEGVYYDTKVDI
HHHHCCCCCCCCEEE		13.3828132839
197PhosphorylationVIMEGVYYDTKVDIW
HHHCCCCCCCCEEEE		18.0928132839
199PhosphorylationMEGVYYDTKVDIWSL
HCCCCCCCCEEEEEE		19.4927017623
310PhosphorylationNKYKIEGSIPENEPS
CCEEEECCCCCCCCC		23.3721551504
317PhosphorylationSIPENEPSKPSEAPK
CCCCCCCCCCCCCCC		51.5321551504
320PhosphorylationENEPSKPSEAPKPSQ
CCCCCCCCCCCCCCC		50.5624961812
326PhosphorylationPSEAPKPSQNGGGDE
CCCCCCCCCCCCCHH		42.2623749301
337PhosphorylationGGDEAQKSIASNDNE
CCHHHHHHHHCCCCC		16.0021440633
340PhosphorylationEAQKSIASNDNEIKR
HHHHHHHCCCCCCEE		42.9421440633
421PhosphorylationPFVYQGTTIGKGYPG
CEEEECCCCCCCCCC		34.2625704821
434PhosphorylationPGTIAQNSTLNAPVT
CCCCCCCCCCCCCCC		23.3821440633
435PhosphorylationGTIAQNSTLNAPVTN
CCCCCCCCCCCCCCC		31.4221440633
441PhosphorylationSTLNAPVTNNYTNSK
CCCCCCCCCCCCCCC		19.3823749301
444PhosphorylationNAPVTNNYTNSKYPS
CCCCCCCCCCCCCCC		14.9023749301
445PhosphorylationAPVTNNYTNSKYPSK
CCCCCCCCCCCCCCC		34.8321440633
457PhosphorylationPSKMVAGTTNTSGTH
CCCEEEECCCCCCCC		13.7221440633
458PhosphorylationSKMVAGTTNTSGTHT
CCEEEECCCCCCCCC		35.2621440633
460PhosphorylationMVAGTTNTSGTHTAG
EEEECCCCCCCCCCC		26.8321440633
461PhosphorylationVAGTTNTSGTHTAGP
EEECCCCCCCCCCCC		43.7121440633
463PhosphorylationGTTNTSGTHTAGPMT
ECCCCCCCCCCCCCC		18.8021440633
465PhosphorylationTNTSGTHTAGPMTSS
CCCCCCCCCCCCCCC		32.9021551504
471PhosphorylationHTAGPMTSSKRLESK
CCCCCCCCCHHHHCC		27.8421440633
472PhosphorylationTAGPMTSSKRLESKA
CCCCCCCCHHHHCCC		16.7821551504
509PhosphorylationEAPKISKSISSLNAG
CCCCCCHHHHHCCCC		22.4022369663
511PhosphorylationPKISKSISSLNAGNS
CCCCHHHHHCCCCCC		35.5422369663
512PhosphorylationKISKSISSLNAGNSS
CCCHHHHHCCCCCCC		24.7922369663
518PhosphorylationSSLNAGNSSRDDFIP
HHCCCCCCCHHHCHH		26.3222369663
519PhosphorylationSLNAGNSSRDDFIPS
HCCCCCCCHHHCHHH		43.6721440633
526PhosphorylationSRDDFIPSISNEVNG
CHHHCHHHHHHCCCC		33.5622369663
528PhosphorylationDDFIPSISNEVNGNI
HHCHHHHHHCCCCCC		31.1322369663
557PhosphorylationGNNYYSQSTPALPLL
CCCCCCCCCCCHHHE		30.3421440633
558PhosphorylationNNYYSQSTPALPLLQ
CCCCCCCCCCHHHEE		12.6324961812
618PhosphorylationIPSTKARSSTVTAGT
ECCCCCCCCEEECCC		34.9121440633
619PhosphorylationPSTKARSSTVTAGTP
CCCCCCCCEEECCCC		22.7321082442
620PhosphorylationSTKARSSTVTAGTPS
CCCCCCCEEECCCCC		24.1121082442
622PhosphorylationKARSSTVTAGTPSSS
CCCCCEEECCCCCCC		21.3223749301
625PhosphorylationSSTVTAGTPSSSSSI
CCEEECCCCCCCCCC		19.9621440633
627PhosphorylationTVTAGTPSSSSSIQY
EEECCCCCCCCCCEE		42.5619779198
628PhosphorylationVTAGTPSSSSSIQYK
EECCCCCCCCCCEEC		35.1321440633
630PhosphorylationAGTPSSSSSIQYKSP
CCCCCCCCCCEECCC		33.1519779198
631PhosphorylationGTPSSSSSIQYKSPS
CCCCCCCCCEECCCC		18.6921440633
634PhosphorylationSSSSSIQYKSPSNVP
CCCCCCEECCCCCCC		16.2621440633
636PhosphorylationSSSIQYKSPSNVPRR
CCCCEECCCCCCCCC		28.7328152593
638PhosphorylationSIQYKSPSNVPRRLT
CCEECCCCCCCCCEE		58.5123749301
645PhosphorylationSNVPRRLTVSNNRPE
CCCCCCEEECCCCCC		21.7823607784
647PhosphorylationVPRRLTVSNNRPEHC
CCCCEEECCCCCCCC		24.1323607784
674PhosphorylationVASNSGISSTPNNSN
HHCCCCCCCCCCCCC		31.5223749301
676PhosphorylationSNSGISSTPNNSNNY
CCCCCCCCCCCCCCC		24.2023749301
680PhosphorylationISSTPNNSNNYNNNT
CCCCCCCCCCCCCCC		32.8528889911
700PhosphorylationRGSSGSNTANSTQMG
CCCCCCCCCCCCCCC		28.9828889911
723PhosphorylationKLSTHKASSPSRPLF
EEECCCCCCCCCCCC		47.8122369663
724PhosphorylationLSTHKASSPSRPLFG
EECCCCCCCCCCCCC		31.5822369663
726PhosphorylationTHKASSPSRPLFGVG
CCCCCCCCCCCCCCC		48.7722369663
734PhosphorylationRPLFGVGTSPNRKPA
CCCCCCCCCCCCCCC		38.3122369663
735PhosphorylationPLFGVGTSPNRKPAG
CCCCCCCCCCCCCCC		17.7822369663
743PhosphorylationPNRKPAGSPTQNIGH
CCCCCCCCCCCCCCC		27.2120377248
745PhosphorylationRKPAGSPTQNIGHNS
CCCCCCCCCCCCCCC		35.6321551504
752PhosphorylationTQNIGHNSTHTNLAP
CCCCCCCCCCCCCCC		18.8520377248
753PhosphorylationQNIGHNSTHTNLAPP
CCCCCCCCCCCCCCC		37.7321551504
901PhosphorylationFGGKIKRSQSISNRK
CCCCCCCHHHCCCCC		24.2330377154
903PhosphorylationGKIKRSQSISNRKNS
CCCCCHHHCCCCCCC		29.2724909858
905PhosphorylationIKRSQSISNRKNSSA
CCCHHHCCCCCCCCC		35.5127717283
1072PhosphorylationALKEQLISTPIKDNE
HHHHHHHCCCCCCCC		36.4022369663
1073PhosphorylationLKEQLISTPIKDNEH
HHHHHHCCCCCCCCC		23.2622369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KIC1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KIC1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KIC1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HSC82_YEASTHSC82physical
9813095
CDC31_YEASTCDC31physical
9813095
MSG5_YEASTMSG5genetic
12480907
RHO3_YEASTRHO3genetic
12480907
STB3_YEASTSTB3genetic
12480907
RAS2_YEASTRAS2genetic
14871942
CDC31_YEASTCDC31genetic
9813095
SSD1_YEASTSSD1genetic
12454058
KCS1_YEASTKCS1physical
16554755
PIK1_YEASTPIK1physical
16554755
CBK1_YEASTCBK1genetic
16552603
MOB2_YEASTMOB2genetic
16552603
ACE2_YEASTACE2genetic
15947194
HYM1_YEASTHYM1physical
11283351
CBK1_YEASTCBK1genetic
19967545
ACE2_YEASTACE2genetic
19967545
HYM1_YEASTHYM1genetic
19967545
XPO1_YEASTCRM1genetic
19967545
TCPQ_YEASTCCT8physical
20489023
IMB4_YEASTKAP123physical
20489023
MDM30_YEASTMDM30physical
20489023
TREB_YEASTNTH2physical
20489023
PFKA1_YEASTPFK1physical
20489023
METK1_YEASTSAM1physical
20489023
SKP1_YEASTSKP1physical
20489023
SOG2_YEASTSOG2physical
20489023
SUB2_YEASTSUB2physical
20489023
HOG1_YEASTHOG1physical
21118957
HYM1_YEASTHYM1physical
21118957
KRE9_YEASTKRE9genetic
12480907
KRE6_YEASTKRE6genetic
12480907
KRE1_YEASTKRE1genetic
12480907
FKS1_YEASTFKS1genetic
12480907
CBK1_YEASTCBK1physical
24205201
HYM1_YEASTHYM1physical
24205201
PP2B1_YEASTCNA1physical
24930733
PP2B2_YEASTCMP2physical
24930733
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KIC1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-512; SER-723; SER-724;THR-734; SER-735 AND THR-1073, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-724 AND THR-1073, ANDMASS SPECTROMETRY.

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