| UniProt ID | SOG2_YEAST | |
|---|---|---|
| UniProt AC | Q08817 | |
| Protein Name | Leucine-rich repeat-containing protein SOG2 | |
| Gene Name | SOG2 {ECO:0000312|SGD:S000005880} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 791 | |
| Subcellular Localization | Cytoplasm . Localizes to cortical sites of growth during both budding and mating pheromone response. Localized prominently to incipient bud sites and small buds and weakly to the cortex and bud necks of large budded cells. Also localized to the growi | |
| Protein Description | Required for proper cell morphogenesis and cell separation after mitosis. Functions in the RAM (regulation of ACE2 activity and cellular morphogenesis) signaling network and is required for proper ACE2 localization and CBK1 kinase activity.. | |
| Protein Sequence | MVATSSKRTLDPKEEHLPADKTSTNSSNTIISELATQEKSSSSGTTLKLIALNIKSISDEDVGYIQNVERLSLRKNHLTSLPASFKRLSRLQYLDLHNNNFKEIPYILTQCPQLEILDLSSNEIEALPDEISSFWQDNIRVLSLKDNNVTSIRNLKSITKLNKLSILDLEDNKIPKEELDQVQSYTPFHTGIPKEEYWAIAISRYLKDHPNLPTPEPKISRAAKRMGFINTNLSNGAMNENNIISLAPSANTTISASTAMVSSNQTSATSFSGTVNAESEQSGAVNGTELYNHTKYNDYFKRLSILPEESMSNGHQKISHAELVVSCRKLLFSFTECQQAIRKIASFCKEKAVAVNVVSLLYSVRSHTDNLVEVLQQTENEDESHDQALIKLCLTIITNFKQIITLLRKNFEIFFKEDDLCFIRMFYMTLMCAYMEMYNAWSFIKEDDQVSGSASKAPKKHSFSRHETSSSSITSGGGPAASTTSTHCSGNIKLLPKTRSTRTPSASALLSNSNILTGDTTAVPLLSPNLNGAHTHGPILGHQNAISNGSSQTNMNEVKTTSDTIPRQQLLQHNKSISDSKKESQAHEPKQHPVMTSSIINASNSNNVSNVNITPPPMNGGGAANSSANVVETNIDIQLYQTLSTVVKMVSVVYNQLTSEISKIAIASTMGKQILTDSLAPKIRDLTETCRQAMDLSKQLNERLNVLIPNDSNSEKYLTSLEKLKTWEIMNSFLKVIISILANTKIVMSDVPNLNELRPNLANLAKITKDVTVILDLSSYKAVSVSANSPE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 46 | Phosphorylation | KSSSSGTTLKLIALN CCCCCCCCEEEEEEE | 25.97 | 28889911 | |
| 150 | Phosphorylation | SLKDNNVTSIRNLKS ECCCCCCCCEECHHH | 22.14 | 27017623 | |
| 159 | Phosphorylation | IRNLKSITKLNKLSI EECHHHHHHHCCCEE | 36.25 | 27017623 | |
| 184 | Phosphorylation | EELDQVQSYTPFHTG HHHHHHHHCCCCCCC | 31.92 | 21440633 | |
| 214 | Phosphorylation | KDHPNLPTPEPKISR HCCCCCCCCCCHHHH | 43.37 | 20377248 | |
| 304 | Phosphorylation | NDYFKRLSILPEESM CHHHHHHHCCCHHHC | 26.55 | 21440633 | |
| 310 | Phosphorylation | LSILPEESMSNGHQK HHCCCHHHCCCCCCC | 26.33 | 30377154 | |
| 453 | Phosphorylation | EDDQVSGSASKAPKK CCCCCCCCCCCCCCC | 23.12 | 28889911 | |
| 468 | Phosphorylation | HSFSRHETSSSSITS CCCCCCCCCCCCCCC | 27.99 | 23749301 | |
| 658 | Phosphorylation | SVVYNQLTSEISKIA HHHHHHHHHHHHHHH | 17.98 | 28889911 | |
| 659 | Phosphorylation | VVYNQLTSEISKIAI HHHHHHHHHHHHHHH | 41.34 | 28889911 | |
| 662 | Phosphorylation | NQLTSEISKIAIAST HHHHHHHHHHHHHHH | 17.60 | 28889911 | |
| 779 | Phosphorylation | TVILDLSSYKAVSVS EEEEECCCCCEEEEE | 37.64 | 28889911 | |
| 784 | Phosphorylation | LSSYKAVSVSANSPE CCCCCEEEEECCCCC | 18.40 | 21126336 | |
| 789 | Phosphorylation | AVSVSANSPE----- EEEEECCCCC----- | 30.07 | 25521595 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SOG2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SOG2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SOG2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-214, AND MASSSPECTROMETRY. | |
