APJ1_YEAST - dbPTM
APJ1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID APJ1_YEAST
UniProt AC P53940
Protein Name J domain-containing protein APJ1
Gene Name APJ1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 528
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Putative chaperone involved in protein folding. Interferes with propagation of [PSI+] prion when overproduced..
Protein Sequence MQQNTSLYDSLNVTAAASTSEIKKAYRNAALKYHPDKNNHTEESKRKFQEICQAYEILKDNRLRALYDQYGTTDEVLIQEQQAQAQRQQAGPFSSSSNFDTEAMSFPDLSPGDLFAQFFNSSATPSSNGSKSSFNFSFNNSSTPSFSFVNGSGVNNLYSSSAKYNSNDEDHHLDRGPDIKHNLKCTLKELYMGKTAKLGLNRTRICSVCDGHGGLKKCTCKTCKGQGIQTQTRRMGPLVQSWSQTCADCGGAGVFVKNKDICQQCQGLGFIKERKILQVTVQPGSCHNQLIVLTGEGDEVISTKGGGHEKVIPGDVVITILRLKDPNFQVINYSNLICKKCKIDFMTSLCGGVVYIEGHPSGKLIKLDIIPGEILKPGCFKTVEDMGMPKFINGVRSGFGHLYVKFDVTYPERLEPENAKKIQNILANDKYIKAERSTMETADSDCYCDLEKSYDSVEEHVLSSFEAPNLNNEVIEDDDLGDLINERDSRKRNNRRFDESNINNNNETKRNKYSSPVSGFYDHDINGY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MQQNTSLYDSLN
---CCCCCCHHHHHC		18.7728889911
10PhosphorylationQNTSLYDSLNVTAAA
CCCCHHHHHCHHHCC		14.3228889911
14PhosphorylationLYDSLNVTAAASTSE
HHHHHCHHHCCCHHH		14.9830377154
19PhosphorylationNVTAAASTSEIKKAY
CHHHCCCHHHHHHHH		26.1730377154
20PhosphorylationVTAAASTSEIKKAYR
HHHCCCHHHHHHHHH		34.5230377154
94PhosphorylationRQQAGPFSSSSNFDT
HHHHCCCCCCCCCCC		32.2329688323
95PhosphorylationQQAGPFSSSSNFDTE
HHHCCCCCCCCCCCC		37.8629688323
96PhosphorylationQAGPFSSSSNFDTEA
HHCCCCCCCCCCCCH		28.2729688323
97PhosphorylationAGPFSSSSNFDTEAM
HCCCCCCCCCCCCHH		43.3929688323
101PhosphorylationSSSSNFDTEAMSFPD
CCCCCCCCCHHCCCC		22.8529688323
105PhosphorylationNFDTEAMSFPDLSPG
CCCCCHHCCCCCCHH		40.4529688323
110PhosphorylationAMSFPDLSPGDLFAQ
HHCCCCCCHHHHHHH		33.9329688323
121PhosphorylationLFAQFFNSSATPSSN
HHHHHHCCCCCCCCC		19.0529688323
122PhosphorylationFAQFFNSSATPSSNG
HHHHHCCCCCCCCCC		36.9529688323
124PhosphorylationQFFNSSATPSSNGSK
HHHCCCCCCCCCCCC		26.1729688323
126PhosphorylationFNSSATPSSNGSKSS
HCCCCCCCCCCCCCE		31.8929688323
127PhosphorylationNSSATPSSNGSKSSF
CCCCCCCCCCCCCEE		46.5529688323
130PhosphorylationATPSSNGSKSSFNFS
CCCCCCCCCCEEEEE		33.3529688323
166PhosphorylationSSSAKYNSNDEDHHL
CCCCCCCCCCCCCCC		42.4421440633
224UbiquitinationKCTCKTCKGQGIQTQ
CEEECCCCCCCCCCC		60.5423749301
444PhosphorylationSTMETADSDCYCDLE
HHCHHCCCCCCCCHH		27.4123749301
513PhosphorylationNETKRNKYSSPVSGF
CHHHCCCCCCCCCCC		20.2422369663
514PhosphorylationETKRNKYSSPVSGFY
HHHCCCCCCCCCCCC		29.7622369663
515PhosphorylationTKRNKYSSPVSGFYD
HHCCCCCCCCCCCCC		26.6522369663
518PhosphorylationNKYSSPVSGFYDHDI
CCCCCCCCCCCCCCC		26.9421440633
521PhosphorylationSSPVSGFYDHDINGY
CCCCCCCCCCCCCCC		18.8519823750
528PhosphorylationYDHDINGY-------
CCCCCCCC-------		15.7619823750
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of APJ1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of APJ1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of APJ1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SLX5_YEASTSLX5genetic
23329686
ASK10_YEASTASK10genetic
27708008
PEX22_YEASTPEX22genetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
MGR1_YEASTMGR1genetic
27708008
SLX5_YEASTSLX5genetic
27708008
PEX19_YEASTPEX19genetic
27708008
BRE1_YEASTBRE1genetic
27708008
MDHP_YEASTMDH3genetic
27708008
VPS41_YEASTVPS41genetic
27708008
SAC3_YEASTSAC3genetic
27708008
SLX8_YEASTSLX8genetic
27708008
RTF1_YEASTRTF1genetic
27708008
MED20_YEASTSRB2genetic
27708008
ELM1_YEASTELM1genetic
27708008
CTK1_YEASTCTK1genetic
27708008
UBR2_YEASTUBR2genetic
27708008
NU188_YEASTNUP188genetic
27708008
MLH1_YEASTMLH1genetic
27708008
CY1_YEASTCYT1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of APJ1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-515 AND TYR-528, ANDMASS SPECTROMETRY.

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