| UniProt ID | CDS1_YEAST | |
|---|---|---|
| UniProt AC | P38221 | |
| Protein Name | Phosphatidate cytidylyltransferase | |
| Gene Name | CDS1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 457 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle. Exclusively present in the ER, and not in mitochondria. Also associated with post-Golgi apparatus secretory vesicles destined for the plasma membrane |
|
| Protein Description | Supplies CDP-diacylglycerol, which may play an important role as both a precursor to phosphoinositide biosynthesis in the plasma membrane and as a negative effector of phosphatidylinositol 4-kinase activity, thereby exerting an effect on cell proliferation via a lipid-dependent signal transduction cascade.. | |
| Protein Sequence | MSDNPEMKPHGTSKEIVESVTDATSKAIDKLQEELHKDASESVTPVTKESTAATKESRKYNFFIRTVWTFVMISGFFITLASGHAWCIVLILGCQIATFKECIAVTSASGREKNLPLTKTLNWYLLFTTIYYLDGKSLFKFFQATFYEYPVLNFIVTNHKFICYCLYLMGFVLFVCSLRKGFLKFQFGSLCVTHMVLLLVVFQAHLIIKNVLNGLFWFLLPCGLVIVNDIFAYLCGITFGKTKLIEISPKKTLEGFLGAWFFTALASIILTRILSPYTYLTCPVEDLHTNFFSNLTCELNPVFLPQVYRLPPIFFDKVQINSITVKPIYFHALNLATFASLFAPFGGFFASGLKRTFKVKDFGHSIPGHGGITDRVDCQFIMGSFANLYYETFISEHRITVDTVLSTILMNLNDKQIIELIDILIRFLSKKGIISAKNFEKLADIFNVTKKSLTNHS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSDNPEMKP ------CCCCCCCCC | 46.20 | 30377154 | |
| 8 | Acetylation | MSDNPEMKPHGTSKE CCCCCCCCCCCCCHH | 32.00 | 24489116 | |
| 12 | Phosphorylation | PEMKPHGTSKEIVES CCCCCCCCCHHHHHH | 33.32 | 30377154 | |
| 13 | Phosphorylation | EMKPHGTSKEIVESV CCCCCCCCHHHHHHH | 32.65 | 30377154 | |
| 14 | Acetylation | MKPHGTSKEIVESVT CCCCCCCHHHHHHHH | 51.83 | 24489116 | |
| 19 | Phosphorylation | TSKEIVESVTDATSK CCHHHHHHHHHHHHH | 21.30 | 27214570 | |
| 21 | Phosphorylation | KEIVESVTDATSKAI HHHHHHHHHHHHHHH | 29.24 | 24961812 | |
| 24 | Phosphorylation | VESVTDATSKAIDKL HHHHHHHHHHHHHHH | 33.30 | 24961812 | |
| 25 | Phosphorylation | ESVTDATSKAIDKLQ HHHHHHHHHHHHHHH | 23.08 | 24961812 | |
| 30 | Acetylation | ATSKAIDKLQEELHK HHHHHHHHHHHHHHH | 46.05 | 24489116 | |
| 37 | Ubiquitination | KLQEELHKDASESVT HHHHHHHHCHHHCCC | 68.56 | 23749301 | |
| 40 | Phosphorylation | EELHKDASESVTPVT HHHHHCHHHCCCCCC | 40.30 | 22369663 | |
| 42 | Phosphorylation | LHKDASESVTPVTKE HHHCHHHCCCCCCHH | 28.88 | 22369663 | |
| 44 | Phosphorylation | KDASESVTPVTKEST HCHHHCCCCCCHHHC | 22.71 | 22369663 | |
| 47 | Phosphorylation | SESVTPVTKESTAAT HHCCCCCCHHHCCCC | 30.23 | 22369663 | |
| 48 | Ubiquitination | ESVTPVTKESTAATK HCCCCCCHHHCCCCH | 50.32 | 23749301 | |
| 248 | Phosphorylation | KTKLIEISPKKTLEG CCEEEEECCCCCHHH | 20.20 | 20377248 | |
| 360 | Acetylation | LKRTFKVKDFGHSIP CCEEEEECCCCCCCC | 48.18 | 24489116 | |
| 437 | Acetylation | KKGIISAKNFEKLAD HCCCCCCCCHHHHHH | 56.21 | 24489116 | |
| 441 | Acetylation | ISAKNFEKLADIFNV CCCCCHHHHHHHHHC | 44.85 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CDS1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CDS1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CDS1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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