| UniProt ID | SND1_YEAST | |
|---|---|---|
| UniProt AC | Q04007 | |
| Protein Name | SRP-independent targeting protein 1 {ECO:0000303|PubMed:27905431} | |
| Gene Name | SND1 {ECO:0000303|PubMed:27905431} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 877 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Functions in the SND pathway, a SRP (signal recognition particle) and GET (guided entry of tail-anchored proteins) independent pathway for targeting a broad range of substrate proteins to the endoplasmic reticulum. SND functions in parallel to GET in targeting proteins with downstream hydrophobic motifs.. | |
| Protein Sequence | MDTVGTDAAAASINERRFAQSTSPKVSVKSQDSLFLITYSNMQQTVVQASLADRYPSLKKLNILLYIDIPTIDYYNDEMTHNKLSRLNKRFKLHRLRNSIAQSFSNTSTAEDNDKFWEELKSLISSRSTPENKFDLNVLVSSSGSLRYVETIRFLVEKLFNSFKDLYVQKKLNLCFQINVSPTSLKWFSTFLNAELLNLKIINWQNIGSFTKTIQNSKSLPFKEYYTKLNEKFTGSNQSNGSMQDQTVLDSIVIVTNSTGVKALLTLLSDHPLTSLISQESIKALHEYSDAVNEDKGDDQSNTSLKRNSSSLLNFQNSVLTSNKDKSVRIRSLSINRKSNRAHMFKTNESITTIPSTSINNLIGQESNLRKQPSGTALHLQSHLHPHSRSQSYSSSNMSRSPSPFPYGKTPSNDELVYDELNNQINEVQDRAKNEEIVLYNNNNYDDYTKERGEQEQDRTSYADEYGFNYDDEEGGNEDNYDDDEDDDDDDDDDDESDDEGLSFYAPSILSRSGSSTDVLSSGIDSMAKNSKETRGRFRSLSLMDPALQKPFNQKFPNSQQPDSAGASSPKRSTSSNHFTNVYVHDGDFDGTDTINNKKNLSSATLIKRKSLMNRNLAPSISNGLIPPEFISRISTPSTSASSSNSSLNDMSTVSNAFSKLLNDTSKKQKFLNSPIPQHTQQASPLLMRNNSNSNLLFEKNLINKSFEELRRQPSVNLFSTLMNGNMEKNGLALNFKSRTPTDALMANSIKNSNNSSHRLLNLEEEDQIMSGSLPKEREDDNDSTNSTIVPNHPDNDNYNDNDNDNNTGINSNNFNLNLYDDNDSAGFTDVTTEGVKYSNSNSTVTKPVYKKAVTLDLYGEDDMDNMGGWVLGGNAR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 21 | Phosphorylation | NERRFAQSTSPKVSV HHHHHCCCCCCCEEE | 30377154 | ||
| 22 | Phosphorylation | ERRFAQSTSPKVSVK HHHHCCCCCCCEEEC | 30377154 | ||
| 23 | Phosphorylation | RRFAQSTSPKVSVKS HHHCCCCCCCEEECC | 23749301 | ||
| 33 | Phosphorylation | VSVKSQDSLFLITYS EEECCCCEEEEEEEC | 29136822 | ||
| 38 | Phosphorylation | QDSLFLITYSNMQQT CCEEEEEEECCHHHH | 29136822 | ||
| 39 | Phosphorylation | DSLFLITYSNMQQTV CEEEEEEECCHHHHH | 29136822 | ||
| 40 | Phosphorylation | SLFLITYSNMQQTVV EEEEEEECCHHHHHH | 29136822 | ||
| 45 | Phosphorylation | TYSNMQQTVVQASLA EECCHHHHHHHHHHH | 29136822 | ||
| 50 | Phosphorylation | QQTVVQASLADRYPS HHHHHHHHHHHHCCC | 29136822 | ||
| 125 | Phosphorylation | EELKSLISSRSTPEN HHHHHHHHCCCCCCC | 19779198 | ||
| 200 | Ubiquitination | NAELLNLKIINWQNI CHHHHCCEEECCEEC | 17644757 | ||
| 212 | Ubiquitination | QNIGSFTKTIQNSKS EECCCCCHHHHCCCC | 17644757 | ||
| 262 | Ubiquitination | VTNSTGVKALLTLLS EECCHHHHHHHHHHC | 17644757 | ||
| 278 | Phosphorylation | HPLTSLISQESIKAL CCHHHHCCHHHHHHH | 21440633 | ||
| 281 | Phosphorylation | TSLISQESIKALHEY HHHCCHHHHHHHHHH | 21440633 | ||
| 283 | Ubiquitination | LISQESIKALHEYSD HCCHHHHHHHHHHHH | 17644757 | ||
| 296 | Ubiquitination | SDAVNEDKGDDQSNT HHHHCCCCCCCCCCC | 15699485 | ||
| 301 | Phosphorylation | EDKGDDQSNTSLKRN CCCCCCCCCCHHHCC | 21440633 | ||
| 303 | Phosphorylation | KGDDQSNTSLKRNSS CCCCCCCCHHHCCHH | 21440633 | ||
| 304 | Phosphorylation | GDDQSNTSLKRNSSS CCCCCCCHHHCCHHH | 21551504 | ||
| 306 | Ubiquitination | DQSNTSLKRNSSSLL CCCCCHHHCCHHHHH | 15699485 | ||
| 309 | Phosphorylation | NTSLKRNSSSLLNFQ CCHHHCCHHHHHHHH | 22369663 | ||
| 310 | Phosphorylation | TSLKRNSSSLLNFQN CHHHCCHHHHHHHHH | 22369663 | ||
| 311 | Phosphorylation | SLKRNSSSLLNFQNS HHHCCHHHHHHHHHH | 22369663 | ||
| 318 | Phosphorylation | SLLNFQNSVLTSNKD HHHHHHHHCCCCCCC | 22369663 | ||
| 321 | Phosphorylation | NFQNSVLTSNKDKSV HHHHHCCCCCCCCCE | 19823750 | ||
| 322 | Phosphorylation | FQNSVLTSNKDKSVR HHHHCCCCCCCCCEE | 19823750 | ||
| 324 | Ubiquitination | NSVLTSNKDKSVRIR HHCCCCCCCCCEEEE | 23749301 | ||
| 332 | Phosphorylation | DKSVRIRSLSINRKS CCCEEEEEEEECCCC | 17287358 | ||
| 334 | Phosphorylation | SVRIRSLSINRKSNR CEEEEEEEECCCCCC | 17287358 | ||
| 346 | Ubiquitination | SNRAHMFKTNESITT CCCCEEEECCCCCCC | 17644757 | ||
| 356 | Phosphorylation | ESITTIPSTSINNLI CCCCCCCCCHHHHHC | 23749301 | ||
| 367 | Phosphorylation | NNLIGQESNLRKQPS HHHCCCCCCCCCCCC | 23749301 | ||
| 371 | Ubiquitination | GQESNLRKQPSGTAL CCCCCCCCCCCCCEE | 17644757 | ||
| 374 | Phosphorylation | SNLRKQPSGTALHLQ CCCCCCCCCCEEHHH | 23749301 | ||
| 382 | Phosphorylation | GTALHLQSHLHPHSR CCEEHHHHCCCCCCC | 23749301 | ||
| 392 | Phosphorylation | HPHSRSQSYSSSNMS CCCCCCCCCCCCCCC | 23749301 | ||
| 393 | Phosphorylation | PHSRSQSYSSSNMSR CCCCCCCCCCCCCCC | 23749301 | ||
| 399 | Phosphorylation | SYSSSNMSRSPSPFP CCCCCCCCCCCCCCC | 25704821 | ||
| 403 | Phosphorylation | SNMSRSPSPFPYGKT CCCCCCCCCCCCCCC | 28889911 | ||
| 409 | Ubiquitination | PSPFPYGKTPSNDEL CCCCCCCCCCCCCHH | 22817900 | ||
| 410 | Phosphorylation | SPFPYGKTPSNDELV CCCCCCCCCCCCHHH | 22369663 | ||
| 412 | Phosphorylation | FPYGKTPSNDELVYD CCCCCCCCCCHHHHH | 25521595 | ||
| 418 | Phosphorylation | PSNDELVYDELNNQI CCCCHHHHHHHHHHH | 23749301 | ||
| 433 | Ubiquitination | NEVQDRAKNEEIVLY HHHHHHHCCCCEEEE | 23749301 | ||
| 513 | Phosphorylation | APSILSRSGSSTDVL HHHHHHCCCCCHHHH | 22369663 | ||
| 515 | Phosphorylation | SILSRSGSSTDVLSS HHHHCCCCCHHHHHH | 22369663 | ||
| 516 | Phosphorylation | ILSRSGSSTDVLSSG HHHCCCCCHHHHHHH | 22369663 | ||
| 517 | Phosphorylation | LSRSGSSTDVLSSGI HHCCCCCHHHHHHHH | 22890988 | ||
| 529 | Ubiquitination | SGIDSMAKNSKETRG HHHHHHHHCCHHHHH | 23749301 | ||
| 534 | Phosphorylation | MAKNSKETRGRFRSL HHHCCHHHHHHCHHH | 24961812 | ||
| 540 | Phosphorylation | ETRGRFRSLSLMDPA HHHHHCHHHHHCCHH | 17287358 | ||
| 542 | Phosphorylation | RGRFRSLSLMDPALQ HHHCHHHHHCCHHHC | 17330950 | ||
| 550 | Ubiquitination | LMDPALQKPFNQKFP HCCHHHCCCCCCCCC | 17644757 | ||
| 555 | Ubiquitination | LQKPFNQKFPNSQQP HCCCCCCCCCCCCCC | 17644757 | ||
| 559 | Phosphorylation | FNQKFPNSQQPDSAG CCCCCCCCCCCCCCC | 30377154 | ||
| 564 | Phosphorylation | PNSQQPDSAGASSPK CCCCCCCCCCCCCCC | 21440633 | ||
| 568 | Phosphorylation | QPDSAGASSPKRSTS CCCCCCCCCCCCCCC | 25521595 | ||
| 569 | Phosphorylation | PDSAGASSPKRSTSS CCCCCCCCCCCCCCC | 22369663 | ||
| 571 | Ubiquitination | SAGASSPKRSTSSNH CCCCCCCCCCCCCCC | 23749301 | ||
| 573 | Phosphorylation | GASSPKRSTSSNHFT CCCCCCCCCCCCCCE | 22369663 | ||
| 574 | Phosphorylation | ASSPKRSTSSNHFTN CCCCCCCCCCCCCEE | 22369663 | ||
| 575 | Phosphorylation | SSPKRSTSSNHFTNV CCCCCCCCCCCCEEE | 22369663 | ||
| 576 | Phosphorylation | SPKRSTSSNHFTNVY CCCCCCCCCCCEEEE | 22369663 | ||
| 580 | Phosphorylation | STSSNHFTNVYVHDG CCCCCCCEEEEEECC | 20377248 | ||
| 583 | Phosphorylation | SNHFTNVYVHDGDFD CCCCEEEEEECCCCC | 22369663 | ||
| 592 | Phosphorylation | HDGDFDGTDTINNKK ECCCCCCCCCCCCCC | 19823750 | ||
| 594 | Phosphorylation | GDFDGTDTINNKKNL CCCCCCCCCCCCCCC | 19823750 | ||
| 598 | Ubiquitination | GTDTINNKKNLSSAT CCCCCCCCCCCCCHH | 24961812 | ||
| 599 | Ubiquitination | TDTINNKKNLSSATL CCCCCCCCCCCCHHH | 23749301 | ||
| 602 | Phosphorylation | INNKKNLSSATLIKR CCCCCCCCCHHHHHH | 22369663 | ||
| 603 | Phosphorylation | NNKKNLSSATLIKRK CCCCCCCCHHHHHHH | 22369663 | ||
| 605 | Phosphorylation | KKNLSSATLIKRKSL CCCCCCHHHHHHHHH | 22369663 | ||
| 608 | Ubiquitination | LSSATLIKRKSLMNR CCCHHHHHHHHHHCC | 23749301 | ||
| 610 | Ubiquitination | SATLIKRKSLMNRNL CHHHHHHHHHHCCCC | 22817900 | ||
| 635 | Phosphorylation | PEFISRISTPSTSAS HHHHHHCCCCCCCCC | 23749301 | ||
| 646 | Phosphorylation | TSASSSNSSLNDMST CCCCCCCCCHHHHHH | 30377154 | ||
| 652 | Phosphorylation | NSSLNDMSTVSNAFS CCCHHHHHHHHHHHH | 30377154 | ||
| 653 | Phosphorylation | SSLNDMSTVSNAFSK CCHHHHHHHHHHHHH | 30377154 | ||
| 666 | Phosphorylation | SKLLNDTSKKQKFLN HHHHCCHHHHHHHHC | 30377154 | ||
| 667 | Ubiquitination | KLLNDTSKKQKFLNS HHHCCHHHHHHHHCC | 23749301 | ||
| 668 | Ubiquitination | LLNDTSKKQKFLNSP HHCCHHHHHHHHCCC | 22817900 | ||
| 670 | Ubiquitination | NDTSKKQKFLNSPIP CCHHHHHHHHCCCCC | 23749301 | ||
| 674 | Phosphorylation | KKQKFLNSPIPQHTQ HHHHHHCCCCCHHHH | 19684113 | ||
| 680 | Phosphorylation | NSPIPQHTQQASPLL CCCCCHHHHHCCCHH | 21440633 | ||
| 684 | Phosphorylation | PQHTQQASPLLMRNN CHHHHHCCCHHCCCC | 19684113 | ||
| 692 | Phosphorylation | PLLMRNNSNSNLLFE CHHCCCCCCCCCEEE | 22369663 | ||
| 694 | Phosphorylation | LMRNNSNSNLLFEKN HCCCCCCCCCEEEHH | 22369663 | ||
| 700 | Ubiquitination | NSNLLFEKNLINKSF CCCCEEEHHHHHHHH | 23749301 | ||
| 706 | Phosphorylation | EKNLINKSFEELRRQ EHHHHHHHHHHHHCC | 17330950 | ||
| 715 | Phosphorylation | EELRRQPSVNLFSTL HHHHCCCCCCHHHHH | 20377248 | ||
| 720 | Phosphorylation | QPSVNLFSTLMNGNM CCCCCHHHHHHCCCH | 21440633 | ||
| 721 | Phosphorylation | PSVNLFSTLMNGNME CCCCHHHHHHCCCHH | 19823750 | ||
| 738 | Phosphorylation | GLALNFKSRTPTDAL CEECCCCCCCCCHHH | 22369663 | ||
| 740 | Phosphorylation | ALNFKSRTPTDALMA ECCCCCCCCCHHHHH | 22369663 | ||
| 742 | Phosphorylation | NFKSRTPTDALMANS CCCCCCCCHHHHHHH | 22369663 | ||
| 749 | Phosphorylation | TDALMANSIKNSNNS CHHHHHHHHCCCCCC | 22369663 | ||
| 753 | Phosphorylation | MANSIKNSNNSSHRL HHHHHCCCCCCCCCC | 21440633 | ||
| 756 | Phosphorylation | SIKNSNNSSHRLLNL HHCCCCCCCCCCCCH | 20377248 | ||
| 757 | Phosphorylation | IKNSNNSSHRLLNLE HCCCCCCCCCCCCHH | 20377248 | ||
| 771 | Phosphorylation | EEEDQIMSGSLPKER HHHHHHHHCCCCCCC | 19823750 | ||
| 773 | Phosphorylation | EDQIMSGSLPKERED HHHHHHCCCCCCCCC | 19823750 | ||
| 837 | Ubiquitination | DVTTEGVKYSNSNST EEECCCEEECCCCCC | 17644757 | ||
| 838 | Phosphorylation | VTTEGVKYSNSNSTV EECCCEEECCCCCCC | 21440633 | ||
| 839 | Phosphorylation | TTEGVKYSNSNSTVT ECCCEEECCCCCCCC | 30377154 | ||
| 841 | Phosphorylation | EGVKYSNSNSTVTKP CCEEECCCCCCCCCC | 21440633 | ||
| 843 | Phosphorylation | VKYSNSNSTVTKPVY EEECCCCCCCCCCEE | 28889911 | ||
| 847 | Ubiquitination | NSNSTVTKPVYKKAV CCCCCCCCCEEECCE | 17644757 | ||
| 851 | Ubiquitination | TVTKPVYKKAVTLDL CCCCCEEECCEEEEC | 17644757 | ||
| 852 | Ubiquitination | VTKPVYKKAVTLDLY CCCCEEECCEEEECC | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SND1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SND1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SND1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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