| UniProt ID | KFA_YEAST | |
|---|---|---|
| UniProt AC | Q04066 | |
| Protein Name | Kynurenine formamidase {ECO:0000255|HAMAP-Rule:MF_03014} | |
| Gene Name | BNA7 {ECO:0000255|HAMAP-Rule:MF_03014} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 261 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.. | |
| Protein Sequence | MSNTVRAISPDITLFNKTLTFQEISQNTREAVIYIHGGAWNDPENTPNDFNQLANTIKSMDTESTVCQYSIEYRLSPEITNPRNLYDAVSNITRLVKEKGLTNINMVGHSVGATFIWQILAALKDPQEKMSEAQLQMLGLLQIVKRVFLLDGIYSLKELLVEYPEYDCFTRLAFPDGIQMYEEEPSRVMPYVKKALSRFSIDMHLVHSYSDELLTLRQTNCLISCLQDYQLSFKLYLDDLGLHNDVYKNGKVAKYIFDNIC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | SNTVRAISPDITLFN CCCEEECCCCEEEEC | 22369663 | ||
| 13 | Phosphorylation | RAISPDITLFNKTLT EECCCCEEEECCEEE | 21440633 | ||
| 64 | Phosphorylation | IKSMDTESTVCQYSI HHHCCCCCCCEEEEE | 19779198 | ||
| 86 | Phosphorylation | ITNPRNLYDAVSNIT CCCCCCHHHHHHHHH | 19779198 | ||
| 93 | Phosphorylation | YDAVSNITRLVKEKG HHHHHHHHHHHHHHC | 19779198 | ||
| 248 | Acetylation | GLHNDVYKNGKVAKY CCCCCHHHCCHHHHH | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KFA_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KFA_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KFA_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| YBS1_YEAST | YBR071W | genetic | 27708008 | |
| YAD7_YEAST | YAL037W | genetic | 27708008 | |
| CSG2_YEAST | CSG2 | genetic | 27708008 | |
| BMT2_YEAST | BMT2 | genetic | 27708008 | |
| GPR1_YEAST | GPR1 | genetic | 27708008 | |
| ENT1_YEAST | ENT1 | genetic | 27708008 | |
| GCS1_YEAST | GCS1 | genetic | 27708008 | |
| YG036_YEAST | YGL036W | genetic | 27708008 | |
| TNA1_YEAST | TNA1 | genetic | 27708008 | |
| NPT1_YEAST | NPT1 | genetic | 27708008 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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