| UniProt ID | PCL2_YEAST | |
|---|---|---|
| UniProt AC | P25693 | |
| Protein Name | PHO85 cyclin-2 | |
| Gene Name | PCL2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 308 | |
| Subcellular Localization | Cytoplasm . Nucleus . Localizes to sites of polarized growth, namely the incipient bud site, the bud tip and the bud neck. | |
| Protein Description | G1/S-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Essential for the control of the cell cycle at the G1/S (start) transition. Together with cyclin PCL1, positively controls degradation of sphingoid long chain base kinase LCB4. The PCL2-PHO85 cyclin-CDK holoenzyme phosphorylates LCB4, which is required for its ubiquitination and degradation. PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton.. | |
| Protein Sequence | MSNYEALLKFNRKAVSKEMVQYLASTTASIIKIKKTNSMIDIALPAPPLTKFINRLIKHSNVQTPTLMATSVYLAKLRSIIPSNVYGIETTRHRIFLGCLILAAKTLNDSSPLNKHWAEYTDGLLILREVNTIERELLEYFDWDVTISTDDLITCLSPFLKPIKEEQLYKSQRDCRTLKNFSAQEKDIVNKTSISHSRSSSNMSIPSLASTSTLSTLESRRSNLSNYSNRIRTLPELHESNNISDKFSPRTYNIDSKHDNKENRPIPTIKPFNFSKARPVILKTGLNKQIIKEDTKVKKSNWSNYFKS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 58 | Ubiquitination | KFINRLIKHSNVQTP HHHHHHHHCCCCCCC | 45.64 | 17644757 | |
| 76 | Ubiquitination | ATSVYLAKLRSIIPS HHHHHHHHHHHHCCC | 41.67 | 17644757 | |
| 105 | Ubiquitination | GCLILAAKTLNDSSP HHHHHHHHHCCCCCC | 48.19 | 17644757 | |
| 115 | Ubiquitination | NDSSPLNKHWAEYTD CCCCCCHHHHHHHCC | 48.48 | 17644757 | |
| 200 | Phosphorylation | SISHSRSSSNMSIPS CCCCCCCCCCCCCCC | 25.31 | 27017623 | |
| 211 | Phosphorylation | SIPSLASTSTLSTLE CCCCHHCCCHHHHHH | 21.81 | 27017623 | |
| 213 | Phosphorylation | PSLASTSTLSTLESR CCHHCCCHHHHHHHH | 25.47 | 27017623 | |
| 215 | Phosphorylation | LASTSTLSTLESRRS HHCCCHHHHHHHHHH | 30.91 | 27017623 | |
| 216 | Phosphorylation | ASTSTLSTLESRRSN HCCCHHHHHHHHHHH | 37.34 | 27017623 | |
| 219 | Phosphorylation | STLSTLESRRSNLSN CHHHHHHHHHHHCHH | 35.79 | 27017623 | |
| 246 | Ubiquitination | ESNNISDKFSPRTYN HCCCCCCCCCCCCCC | 40.74 | 17644757 | |
| 248 | Phosphorylation | NNISDKFSPRTYNID CCCCCCCCCCCCCCC | 21.15 | 28889911 | |
| 256 | Phosphorylation | PRTYNIDSKHDNKEN CCCCCCCCCCCCCCC | 28.26 | 28889911 | |
| 257 | Ubiquitination | RTYNIDSKHDNKENR CCCCCCCCCCCCCCC | 51.75 | 17644757 | |
| 261 | Ubiquitination | IDSKHDNKENRPIPT CCCCCCCCCCCCCCC | 63.52 | 17644757 | |
| 270 | Ubiquitination | NRPIPTIKPFNFSKA CCCCCCCCCCCCCCC | 46.14 | 17644757 | |
| 276 | Ubiquitination | IKPFNFSKARPVILK CCCCCCCCCCCEEEC | 44.25 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PCL2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PCL2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PCL2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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