GCSP_YEAST - dbPTM
GCSP_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GCSP_YEAST
UniProt AC P49095
Protein Name Glycine dehydrogenase (decarboxylating), mitochondrial
Gene Name GCV2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1034
Subcellular Localization Mitochondrion.
Protein Description The glycine cleavage system (glycine decarboxylase complex) catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein..
Protein Sequence MLRTRVTALLCRATVRSSTNYVSLARTRSFHSQSILLKTAATDITSTQYSRIFNPDLKNIDRPLDTFARRHLGPSPSDVKKMLKTMGYSDLNAFIEELVPPNILKRRPLKLEAPSKGFCEQEMLQHLEKIANKNHYKVKNFIGKGYYGTILPPVIQRNLLESPEWYTSYTPYQPEISQGRLEALLNFQTVVSDLTGLPVANASLLDEGTAAGEAMLLSFNISRKKKLKYVIDKKLHQQTKSVLHTRAKPFNIEIIEVDCSDIKKAVDVLKNPDVSGCLVQYPATDGSILPPDSMKQLSDALHSHKSLLSVASDLMALTLLKPPAHYGADIVLGSSQRFGVPMGYGGPHAAFFAVIDKLNRKIPGRIVGISKDRLGKTALRLALQTREQHIKRDKATSNICTAQALLANVASSYCVYHGPKGLQNISRRIFSLTSILANAIENDSCPHELINKTWFDTLTIKLGNGISSEQLLDKALKEFNINLFAVDTTTISLALDETTTKADVENLLKVFDIENSSQFLSEDYSNSFPREFQRTDEILRNEVFHMHHSETAMLRYLHRLQSRDLSLANSMIPLGSCTMKLNSTVEMMPITWPQFSNIHPFQPSNQVQGYKELITSLEKDLCSITGFDGISLQPNSGAQGEYTGLRVIRSYLESKGENHRNVCLIPVSAHGTNPASAAMAGLKVVPVNCLQDGSLDLVDLKNKAEQHSKELAAVMITYPSTYGLFEPGIQHAIDIVHSFGGQVYLDGANMNAQVGLTSPGDLGADVCHLNLHKTFSIPHGGGGPAGAPICVKSHLIPHLPKHDVVDMITGIGGSKSIDSVSSAPYGNALVLPISYAYIKMMGNEGLPFSSVIAMLNSNYMMTRLKDHYKILFVNEMSTLKHCAHEFIVDLREYKAKGVEAIDVAKRLQDYGFHAPTLAFPVPGTLMIEPTESENLEELDRFCDAMISIKEEINALVAGQPKGQILKNAPHSLEDLITSSNWDTRGYTREEAAYPLPFLRYNKFWPTVARLDDTYGDMNLICTCPSVEEIANETE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
29PhosphorylationVSLARTRSFHSQSIL
EEEEECCCCCCCCHH		27.0528889911
58AcetylationRIFNPDLKNIDRPLD
HHCCCCCCCCCCCHH		60.2724489116
75PhosphorylationARRHLGPSPSDVKKM
HHHHCCCCHHHHHHH		34.9328152593
77PhosphorylationRHLGPSPSDVKKMLK
HHCCCCHHHHHHHHH		60.4124930733
80AcetylationGPSPSDVKKMLKTMG
CCCHHHHHHHHHHCC		37.1422865919
129AcetylationEMLQHLEKIANKNHY
HHHHHHHHHHCCCCC		54.1824489116
556PhosphorylationSETAMLRYLHRLQSR
CHHHHHHHHHHHHHC		11.6928132839
566PhosphorylationRLQSRDLSLANSMIP
HHHHCCCHHCCCCCC		29.7129688323
570PhosphorylationRDLSLANSMIPLGSC
CCCHHCCCCCCCCCC		16.6929688323
576PhosphorylationNSMIPLGSCTMKLNS
CCCCCCCCCEEECCC		17.6929688323
578PhosphorylationMIPLGSCTMKLNSTV
CCCCCCCEEECCCEE		21.0229688323
701AcetylationSLDLVDLKNKAEQHS
CCCHHCCCHHHHHHC		52.5224489116
708PhosphorylationKNKAEQHSKELAAVM
CHHHHHHCHHHHHHH		27.7621126336
773N6-(pyridoxal phosphate)lysineVCHLNLHKTFSIPHG
EEEEEEECEECCCCC		55.20-
773OtherVCHLNLHKTFSIPHG
EEEEEEECEECCCCC		55.20-
776PhosphorylationLNLHKTFSIPHGGGG
EEEECEECCCCCCCC		40.2023749301
821PhosphorylationSKSIDSVSSAPYGNA
CCCCCCCCCCCCCCE		25.4130377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GCSP_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GCSP_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GCSP_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDC20_YEASTCDC20genetic
27708008
MSC7_YEASTMSC7genetic
27708008
CDC27_YEASTCDC27genetic
27708008
TFC1_YEASTTFC1genetic
27708008
LCB2_YEASTLCB2genetic
27708008
SYF1_YEASTSYF1genetic
27708008
ACT_YEASTACT1genetic
27708008
ERG26_YEASTERG26genetic
27708008
DAM1_YEASTDAM1genetic
27708008
CTF8_YEASTCTF8genetic
27708008
SMC4_YEASTSMC4genetic
27708008
UTP13_YEASTUTP13genetic
27708008
SEC22_YEASTSEC22genetic
27708008
SEC39_YEASTSEC39genetic
27708008
TYSY_YEASTCDC21genetic
27708008
YCY0_YEASTYCR090Cgenetic
27708008
GPR1_YEASTGPR1genetic
27708008
AIM11_YEASTAIM11genetic
27708008
CBP4_YEASTCBP4genetic
27708008
SODM_YEASTSOD2genetic
27708008
PHO86_YEASTPHO86genetic
27708008
VPS17_YEASTVPS17genetic
27708008
SERC_YEASTSER1genetic
27708008
ELP3_YEASTELP3genetic
27708008
YP022_YEASTYPR022Cgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GCSP_YEAST

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Related Literatures of Post-Translational Modification

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