| UniProt ID | EXO84_YEAST | |
|---|---|---|
| UniProt AC | P38261 | |
| Protein Name | Exocyst complex component EXO84 | |
| Gene Name | EXO84 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 753 | |
| Subcellular Localization | Cytoplasmic vesicle, secretory vesicle. Bud. Bud neck. Cell periphery, bud and bud neck. The polarization of EXO84 requires actin cables. | |
| Protein Description | Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis and to the budding site. Also involved in assembly of the spliceosome.. | |
| Protein Sequence | MVEFSLKKARNNWKHVKKSASSPAKQKTPPSPAKPKQKTKKNPYSDLKDPATSYTLPTINARERSRVATSMQRRLSIHNTNYAPPTLDYSMPLPDMPNMIVPNDNVDSSHNNSSFTTENESVSSKGPSNSLNLSTADLSLNDSSYNKVPARSAMRNTVNPSGSNDPFNNSTSLRKMLANPHFNAKDFVHDKLGNASAITIDKFTSNLTDLSIQVQEEVKLNINKSYNEIMTVNNDLNVAMLELKRVRANINDLNEVLDQCTKIAEKRLQLQDQIDQERQGNFNNVESHSNSPALLPPLKAGQNGNLMRRDRSSVLILEKFWDTELDQLFKNVEGAQKFINSTKGRHILMNSANWMELNTTTGKPLQMVQIFILNDLVLIADKSRDKQNDFIVSQCYPLKDVTVTQEEFSTKRLLFKFSNSNSSLYECRDADECSRLLDVIRKAKDDLCDIFHVEEENSKRIRESFRYLQSTQQTPGRENNRSPNKNKRRSMGGSITPGRNVTGAMDQYLLQNLTLSMHSRPRSRDMSSTAQRLKFLDEGVEEIDIELARLRFESAVETLLDIESQLEDLSERISDEELMLLNLISLKIEQRREAISSKLSQSILSSNEIVHLKSGTENMIKLGLPEQALDLFLQNRSNFIQDLILQIGSVDNPTNYLTQLAVIRFQTIKKTVEDFQDIFKELGAKISSILVDWCSDEVDNHFKLIDKQLLNDEMLSPGSIKSSRKQIDGLKAVGLDFVYKLDEFIKKNSDKIR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 19 | Phosphorylation | NWKHVKKSASSPAKQ CHHHHHHCCCCCCCC | 27.89 | 21440633 | |
| 21 | Phosphorylation | KHVKKSASSPAKQKT HHHHHCCCCCCCCCC | 43.90 | 29136822 | |
| 22 | Phosphorylation | HVKKSASSPAKQKTP HHHHCCCCCCCCCCC | 28.70 | 21440633 | |
| 28 | Phosphorylation | SSPAKQKTPPSPAKP CCCCCCCCCCCCCCC | 37.63 | 17563356 | |
| 31 | Phosphorylation | AKQKTPPSPAKPKQK CCCCCCCCCCCCCCC | 38.40 | 21551504 | |
| 52 | Phosphorylation | SDLKDPATSYTLPTI CCCCCCCHHCCCCCC | 27.88 | 19779198 | |
| 53 | Phosphorylation | DLKDPATSYTLPTIN CCCCCCHHCCCCCCC | 20.44 | 19779198 | |
| 55 | Phosphorylation | KDPATSYTLPTINAR CCCCHHCCCCCCCHH | 26.48 | 19779198 | |
| 58 | Phosphorylation | ATSYTLPTINARERS CHHCCCCCCCHHHHH | 29.94 | 19779198 | |
| 128 | Phosphorylation | SVSSKGPSNSLNLST CCCCCCCCCCCCCCC | 47.95 | 28889911 | |
| 130 | Phosphorylation | SSKGPSNSLNLSTAD CCCCCCCCCCCCCCC | 23.99 | 17563356 | |
| 134 | Phosphorylation | PSNSLNLSTADLSLN CCCCCCCCCCCCCCC | 22.07 | 25521595 | |
| 135 | Phosphorylation | SNSLNLSTADLSLND CCCCCCCCCCCCCCC | 27.62 | 25752575 | |
| 139 | Phosphorylation | NLSTADLSLNDSSYN CCCCCCCCCCCCCCC | 26.19 | 29136822 | |
| 143 | Phosphorylation | ADLSLNDSSYNKVPA CCCCCCCCCCCCCCC | 33.38 | 28889911 | |
| 144 | Phosphorylation | DLSLNDSSYNKVPAR CCCCCCCCCCCCCCH | 35.27 | 24961812 | |
| 171 | Phosphorylation | NDPFNNSTSLRKMLA CCCCCCCHHHHHHHH | 33.63 | 28889911 | |
| 219 | Ubiquitination | IQVQEEVKLNINKSY HHHHHHHHHCCCCCH | 38.81 | 12872131 | |
| 287 | Phosphorylation | GNFNNVESHSNSPAL CCCCCCCCCCCCCCC | 28.12 | 23749301 | |
| 289 | Phosphorylation | FNNVESHSNSPALLP CCCCCCCCCCCCCCC | 48.56 | 23749301 | |
| 291 | Phosphorylation | NVESHSNSPALLPPL CCCCCCCCCCCCCCC | 17.98 | 29136822 | |
| 312 | Phosphorylation | NLMRRDRSSVLILEK CCCCCCCCEEEEEEH | 29.14 | 28889911 | |
| 313 | Phosphorylation | LMRRDRSSVLILEKF CCCCCCCEEEEEEHH | 23.10 | 28889911 | |
| 337 | Acetylation | KNVEGAQKFINSTKG CCCHHHHHHHHCCCC | 47.91 | 25381059 | |
| 470 | Phosphorylation | ESFRYLQSTQQTPGR HHHHHHHHHCCCCCC | 26.11 | 17287358 | |
| 471 | Phosphorylation | SFRYLQSTQQTPGRE HHHHHHHHCCCCCCC | 16.25 | 28152593 | |
| 474 | Phosphorylation | YLQSTQQTPGRENNR HHHHHCCCCCCCCCC | 20.21 | 28152593 | |
| 482 | Phosphorylation | PGRENNRSPNKNKRR CCCCCCCCCCCCCCC | 34.64 | 17287358 | |
| 490 | Phosphorylation | PNKNKRRSMGGSITP CCCCCCCCCCCCCCC | 26.30 | 22369663 | |
| 494 | Phosphorylation | KRRSMGGSITPGRNV CCCCCCCCCCCCCCC | 19.98 | 22369663 | |
| 496 | Phosphorylation | RSMGGSITPGRNVTG CCCCCCCCCCCCCCH | 22.76 | 22369663 | |
| 523 | Phosphorylation | SMHSRPRSRDMSSTA HCCCCCCCCCCCHHH | 35.00 | 28889911 | |
| 716 | Phosphorylation | LLNDEMLSPGSIKSS HHCCCCCCCCCCCCC | 26.38 | 28152593 | |
| 719 | Phosphorylation | DEMLSPGSIKSSRKQ CCCCCCCCCCCCHHH | 30.17 | 24961812 | |
| 722 | Phosphorylation | LSPGSIKSSRKQIDG CCCCCCCCCHHHCCH | 33.43 | 19779198 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EXO84_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EXO84_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EXO84_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130; SER-139; SER-143;SER-490 AND SER-716, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-28; SER-31; SER-130 ANDSER-134, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-470 AND SER-482, ANDMASS SPECTROMETRY. | |
| Ubiquitylation | |
| Reference | PubMed |
| "A proteomics approach to understanding protein ubiquitination."; Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.; Nat. Biotechnol. 21:921-926(2003). Cited for: PROTEIN SEQUENCE OF 213-224, MASS SPECTROMETRY, AND UBIQUITINATION[LARGE SCALE ANALYSIS] AT LYS-219. | |
