YFH6_YEAST - dbPTM
YFH6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YFH6_YEAST
UniProt AC P43590
Protein Name Uncharacterized peptidase YFR006W
Gene Name YFR006W
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 535
Subcellular Localization Membrane
Single-pass membrane protein .
Protein Description
Protein Sequence MCLEPISLVVFGSLVFFFGLVKYFKRGERQRTRGILQPEYKDKYYYSKEKGEEMGEVANVNEIPVKIRNHKYPAKEHNLRVKDLLLNRNPKLSKISTAFFIAGEELEGNKYCDTNKDFRQNRYFYHLSGVDIPASAILFNCSTDKLTLFLPNIDEEDVIWSGMPLSLDEAMRVFDIDEALYISDLGKKFKELQDFAIFTTDLDNVHDENIARSLIPSDPNFFYAMDETRAIKDWYEIESIRKACQISDKSHLAVMSALPIELNELQIQAEFEYHATRQGGRSLGYDPICCSGPACGTLHYVKNSEDIKGKHSILIDAGAEWRQYTSDITRCFPTSGKFTAEHREVYETVLDMQNQAMERIKPGAKWDDLHALTHKVLIKHFLSMGIFKKEFSEDEIFKRRASCAFYPHGLGHMLGLDVHDVGGNPNYDDPDPMFRYLRIRRPLKENMVITNEPGCYFNQFLIKEFLEKHPERLEVVDMSVLKRYMYVGGVRIEDDILVTKDGYENLTGITSDPDEIEKIVQKGLKKPRSGFHVIV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
41UbiquitinationGILQPEYKDKYYYSK
CCCCHHHCCCCEEEC		46.1923749301
43UbiquitinationLQPEYKDKYYYSKEK
CCHHHCCCCEEECCC		30.8823749301
48UbiquitinationKDKYYYSKEKGEEMG
CCCCEEECCCCCCCC		47.5322817900
50UbiquitinationKYYYSKEKGEEMGEV
CCEEECCCCCCCCCE		75.3023749301
145UbiquitinationLFNCSTDKLTLFLPN
EEECCCCCEEEECCC		43.3817644757
190UbiquitinationSDLGKKFKELQDFAI
HHHHHHHHHHHCEEE		67.4123749301
232UbiquitinationMDETRAIKDWYEIES
CCHHHHCCCHHHHHH		41.0217644757
242UbiquitinationYEIESIRKACQISDK
HHHHHHHHHHCCCCC		52.4217644757
302UbiquitinationCGTLHYVKNSEDIKG
CCEEEEECCCHHCCC		47.8117644757
365UbiquitinationERIKPGAKWDDLHAL
HHCCCCCCHHHHHHH		58.0117644757
365AcetylationERIKPGAKWDDLHAL
HHCCCCCCHHHHHHH		58.0124489116
375UbiquitinationDLHALTHKVLIKHFL
HHHHHHHHHHHHHHH		33.2417644757
375AcetylationDLHALTHKVLIKHFL
HHHHHHHHHHHHHHH		33.2424489116
398AcetylationFSEDEIFKRRASCAF
CCHHHHHHHHHHHHC		46.7824489116
479PhosphorylationRLEVVDMSVLKRYMY
HCEEEEHHHHHHHHE		21.6027017623
500UbiquitinationEDDILVTKDGYENLT
ECCEEEECCCCHHCC		41.5023749301
518UbiquitinationSDPDEIEKIVQKGLK
CCHHHHHHHHHHCCC		54.5623749301
529PhosphorylationKGLKKPRSGFHVIV-
HCCCCCCCCCEEEC-		55.1022369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YFH6_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YFH6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YFH6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HSP72_YEASTSSA2physical
22940862
HSP71_YEASTSSA1physical
22940862
UTP5_YEASTUTP5genetic
27708008
SED5_YEASTSED5genetic
27708008
RPC6_YEASTRPC34genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
FABG_YEASTOAR1genetic
27708008
CTK1_YEASTCTK1genetic
27708008
CDC24_YEASTCDC24genetic
27708008
CDC27_YEASTCDC27genetic
27708008
KPC1_YEASTPKC1genetic
27708008
MCM7_YEASTMCM7genetic
27708008
SCC1_YEASTMCD1genetic
27708008
RPN6_YEASTRPN6genetic
27708008
LCB2_YEASTLCB2genetic
27708008
RRP1_YEASTRRP1genetic
27708008
RIFK_YEASTFMN1genetic
27708008
NCS1_YEASTFRQ1genetic
27708008
NUP57_YEASTNUP57genetic
27708008
CYAA_YEASTCYR1genetic
27708008
SEC22_YEASTSEC22genetic
27708008
ORC1_YEASTORC1genetic
27708008
HAS1_YEASTHAS1genetic
27708008
NOP2_YEASTNOP2genetic
27708008
MED10_YEASTNUT2genetic
27708008
ATG15_YEASTATG15genetic
27708008
RL13A_YEASTRPL13Agenetic
27708008
BAP3_YEASTBAP3genetic
27708008
ACL4_YEASTYDR161Wgenetic
27708008
YD179_YEASTYDR179W-Agenetic
27708008
CAJ1_YEASTCAJ1genetic
27708008
CEM1_YEASTCEM1genetic
27708008
CGR1_YEASTCGR1genetic
27708008
TFS2_YEASTDST1genetic
27708008
ATG1_YEASTATG1genetic
27708008
VAM7_YEASTVAM7genetic
27708008
YGZ2_YEASTYGL242Cgenetic
27708008
ADH4_YEASTADH4genetic
27708008
SNF6_YEASTSNF6genetic
27708008
SODM_YEASTSOD2genetic
27708008
HTD2_YEASTHTD2genetic
27708008
AIM18_YEASTAIM18genetic
27708008
SNL1_YEASTSNL1genetic
27708008
VPS53_YEASTVPS53genetic
27708008
LPLA_YEASTAIM22genetic
27708008
YJE9_YEASTYJL049Wgenetic
27708008
RPA34_YEASTRPA34genetic
27708008
MPCP_YEASTMIR1genetic
27708008
YJ90_YEASTYJR120Wgenetic
27708008
PRR1_YEASTPRR1genetic
27708008
ELF1_YEASTELF1genetic
27708008
NNK1_YEASTNNK1genetic
27708008
YL032_YEASTYLL032Cgenetic
27708008
UBI4P_YEASTUBI4genetic
27708008
ALAM_YEASTALT1genetic
27708008
ENT2_YEASTENT2genetic
27708008
LIPB_YEASTLIP2genetic
27708008
YL278_YEASTYLR278Cgenetic
27708008
GBLP_YEASTASC1genetic
27708008
RAD14_YEASTRAD14genetic
27708008
LSM7_YEASTLSM7genetic
27708008
ATG3_YEASTATG3genetic
27708008
PDAT_YEASTLRO1genetic
27708008
BRE5_YEASTBRE5genetic
27708008
LAG2_YEASTLAG2genetic
27708008
MSN1_YEASTMSN1genetic
27708008
BUD21_YEASTBUD21genetic
27708008
WHI5_YEASTWHI5genetic
27708008
PUR6_YEASTADE2genetic
27708008
IDH2_YEASTIDH2genetic
27708008
SFL1_YEASTSFL1genetic
27708008
LIPA_YEASTLIP5genetic
27708008
PMT3_YEASTPMT3genetic
27708008
HAP5_YEASTHAP5genetic
27708008
HAT1_YEASTHAT1genetic
27708008
RAD1_YEASTRAD1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
UBA3_YEASTUBA3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YFH6_YEAST

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Related Literatures of Post-Translational Modification
Ubiquitylation
ReferencePubMed
"A subset of membrane-associated proteins is ubiquitinated in responseto mutations in the endoplasmic reticulum degradation machinery.";
Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.;
Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-50, AND MASSSPECTROMETRY.

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