dbPTM

SEC8_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SEC8_YEAST
UniProt AC	P32855
Protein Name	Exocyst complex component SEC8
Gene Name	SEC8
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	1065
Subcellular Localization	Cytoplasm. Cell membrane Peripheral membrane protein. 75% cytoplasmic. 25% associated with the cell membrane.
Protein Description	Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane..
Protein Sequence	MDYLKPAQKGRRRGLSINSLSETQQSAMNSSLDHLQNDLNRINLQWNRILSDNTNPLELALAFLDDTSVGLGHRYEEFNQLKSQIGSHLQDVVNEHSQVFNTNVASYGKAVSSIMQAQEQTLNLKNCLKEANEKITTDKGSLQELNDNNLKYTKMIDVLVNIEELLQIPEKIEENIRKENFHQVQILLERGFILMNNKSLKTVEILKPINQQLELQEHLLFNNLIEEIHDIMYSKSNKTNFTRVTNNDIFKIISISHNGFTSLENYLYNIVNIDIMEHSKTINKNLEQFIHDQSLNKGNIMLQENAATQAPLAPSRNQENEGFNRIGFLLKTINNINKLPVAFNIITERAKEEIHNIIVKSTESIRSKHPSLLKMATSLKNDNHFGLPVQDILSIILRECFWEIFLKLLYAIQCHRAIFEMSNILQPTSSAKPAFKFNKIWGKLLDEIELLLVRYINDPELISSNNGSIKPINGATNNAPTLPKRKNPKIFSLEYNIEDNSSVKDQAFELKALLKDIFPGFSVSSNMDLDSIYVKDESFEQDEPLVPPSVFNMKVILDPFLLFTQSTSTIVPSVLTQNTISSLTFFDDYMNKSFLPKIQMTMDYLFTVEVESNNPYALELSDENHNIFKTALDFQRLFYNLLNVFNTANTFREKISYCILDLLNHFYNYYLGLFNSLIGTSDRHLTRKIITAWLQNGILMDQEQKILNGDETLFHEESIELFKEIPHFYQAGKGLSKSDLFNNLTLDTILQFSASVLWILNWLPGLKKAINIDEVSQEPMLDADRLRSSWTFSESMDLNYSNPSSSPNSLGNLKILLDDKASKKFDETIDGFKTLKFKLITILRFNIRALCIYDIGSFFQNTKIWNMDVGSIELDQNIASLISELRRTESKLKQQLPEKEKNSIFIGLDIVNNYALIKGAKSIKVLNHNGIKKMLRNVNVLQHAYRNLSSEPSKINMNVTMNFYSLCGSSEAELFEYIKDNELPHCSVEDLKTILRLQFSEEMHRQLKRQSTSSTKGSIKPSNKRYTEALEKLSNLEKEQSKEGARTKIGKLKSKLNAVHTANEK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	KGRRRGLSINSLSET CCCCCCCCCCCCCHH	23.65	19684113
19	Phosphorylation	RRGLSINSLSETQQS CCCCCCCCCCHHHHH	31.44	21082442
21	Phosphorylation	GLSINSLSETQQSAM CCCCCCCCHHHHHHH	38.12	23607784
23	Phosphorylation	SINSLSETQQSAMNS CCCCCCHHHHHHHHH	28.65	23607784
26	Phosphorylation	SLSETQQSAMNSSLD CCCHHHHHHHHHHHH	21.48	19779198
30	Phosphorylation	TQQSAMNSSLDHLQN HHHHHHHHHHHHHHH	21.13	23607784
31	Phosphorylation	QQSAMNSSLDHLQND HHHHHHHHHHHHHHH	32.58	19779198
134	Ubiquitination	CLKEANEKITTDKGS HHHHHHHHCCCCCCC	45.20	19722269
139	Ubiquitination	NEKITTDKGSLQELN HHHCCCCCCCHHHHC	48.59	23749301
522	Phosphorylation	KDIFPGFSVSSNMDL HHHCCCCCCCCCCCC	27.31	27017623
525	Phosphorylation	FPGFSVSSNMDLDSI CCCCCCCCCCCCCEE	33.74	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SEC8_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SEC8_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SEC8_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EXO84_YEAST	EXO84	physical	10438536
SEC15_YEAST	SEC15	physical	7615633
SEC6_YEAST	SEC6	physical	7615633
EXO70_YEAST	EXO70	physical	9658167
SEC10_YEAST	SEC10	physical	9658167
SEC15_YEAST	SEC15	physical	9658167
SEC3_YEAST	SEC3	physical	9658167
SEC5_YEAST	SEC5	physical	9658167
SEC6_YEAST	SEC6	physical	9658167
SEC15_YEAST	SEC15	physical	1512289
SEC3_YEAST	SEC3	physical	15788396
SEC15_YEAST	SEC15	physical	15788396
SEC5_YEAST	SEC5	physical	15788396
EXO84_YEAST	EXO84	physical	15788396
SEC10_YEAST	SEC10	physical	15788396
SEC6_YEAST	SEC6	physical	15788396
EXO70_YEAST	EXO70	physical	15788396
SEC6_YEAST	SEC6	physical	15583030
SEC10_YEAST	SEC10	physical	15583030
SEC1_YEAST	SEC1	physical	15583030
SEC15_YEAST	SEC15	physical	15583030
SEC10_YEAST	SEC10	genetic	9658167
SC6B1_YEAST	SBH1	genetic	12665530
SEM1_YEAST	SEM1	genetic	9927667
CDC42_YEAST	CDC42	genetic	11706050
SEC1_YEAST	SEC1	genetic	11063675
SEC2_YEAST	SEC2	genetic	11063675
SEC3_YEAST	SEC3	genetic	11063675
SEC4_YEAST	SEC4	genetic	11063675
SEC5_YEAST	SEC5	genetic	11063675
SEC6_YEAST	SEC6	genetic	11063675
SEC10_YEAST	SEC10	genetic	11063675
SEC15_YEAST	SEC15	genetic	11063675
SEC9_YEAST	SEC9	genetic	11063675
GDI1_YEAST	GDI1	genetic	11063675
DSS4_YEAST	DSS4	genetic	11063675
YPT1_YEAST	YPT1	genetic	11063675
MYO2_YEAST	MYO2	genetic	11063675
CDC42_YEAST	CDC42	genetic	11063675
MSO1_YEAST	MSO1	genetic	16087665
SEC1_YEAST	SEC1	genetic	16087665
SRO7_YEAST	SRO7	genetic	16027223
RPC9_YEAST	RPC17	physical	16429126
SEC10_YEAST	SEC10	physical	16429126
SEC3_YEAST	SEC3	physical	16429126
SEC5_YEAST	SEC5	physical	16429126
SEC6_YEAST	SEC6	physical	16429126
SEC3_YEAST	SEC3	physical	11210526
SEC15_YEAST	SEC15	physical	11210526
SEC5_YEAST	SEC5	physical	11210526
SEC10_YEAST	SEC10	physical	11210526
EXO84_YEAST	EXO84	physical	11210526
SEC6_YEAST	SEC6	physical	11210526
EXO70_YEAST	EXO70	physical	11210526
RTN1_YEAST	RTN1	genetic	16624861
SC61G_YEAST	SSS1	genetic	12665530
SEC9_YEAST	SEC9	genetic	15563607
SAC1_YEAST	SAC1	genetic	2687291
SEC5_YEAST	SEC5	physical	18946089
SEC6_YEAST	SEC6	physical	18946089
SEC3_YEAST	SEC3	physical	19955214
SEC5_YEAST	SEC5	physical	19955214
SEC6_YEAST	SEC6	physical	19955214
SEC10_YEAST	SEC10	physical	19955214
SEC15_YEAST	SEC15	physical	19955214
EXO70_YEAST	EXO70	physical	19955214
EXO84_YEAST	EXO84	physical	19955214
MSS4_YEAST	MSS4	genetic	19477927
SFH5_YEAST	SFH5	genetic	19477927
SRO7_YEAST	SRO7	genetic	10402465
SEC9_YEAST	SEC9	genetic	10402465
SFH5_YEAST	SFH5	genetic	16262726
MSS4_YEAST	MSS4	genetic	16262726
SEC9_YEAST	SEC9	genetic	16262726
SRO7_YEAST	SRO7	genetic	21248204
RV167_YEAST	RVS167	genetic	21554509
SEC3_YEAST	SEC3	genetic	9247645
HSP71_YEAST	SSA1	physical	22940862
PSB3_YEAST	PUP3	genetic	27708008
IMB1_YEAST	KAP95	genetic	27708008
OST2_YEAST	OST2	genetic	27708008
SMD1_YEAST	SMD1	genetic	27708008
PAT1_YEAST	PAT1	genetic	27708008
MON1_YEAST	MON1	genetic	27708008
DBF2_YEAST	DBF2	genetic	27708008
THIK_YEAST	POT1	genetic	27708008
ROM2_YEAST	ROM2	genetic	27708008
PFD4_YEAST	GIM3	genetic	27708008
PSB6_YEAST	PRE7	genetic	27708008
MAK5_YEAST	MAK5	genetic	27708008
NSE4_YEAST	NSE4	genetic	27708008
RPN5_YEAST	RPN5	genetic	27708008
SEC5_YEAST	SEC5	genetic	27708008
NSE3_YEAST	NSE3	genetic	27708008
SMT3_YEAST	SMT3	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
RPN12_YEAST	RPN12	genetic	27708008
SEC15_YEAST	SEC15	genetic	27708008
RRP41_YEAST	SKI6	genetic	27708008
ZPR1_YEAST	ZPR1	genetic	27708008
RPN1_YEAST	RPN1	genetic	27708008
RRP4_YEAST	RRP4	genetic	27708008
SEC6_YEAST	SEC6	genetic	27708008
NU159_YEAST	NUP159	genetic	27708008
RHO3_YEAST	RHO3	genetic	27708008
PRI1_YEAST	PRI1	genetic	27708008
RRN7_YEAST	RRN7	genetic	27708008
EXO70_YEAST	EXO70	genetic	27708008
ESS1_YEAST	ESS1	genetic	27708008
KTHY_YEAST	CDC8	genetic	27708008
PRS7_YEAST	RPT1	genetic	27708008
PRP19_YEAST	PRP19	genetic	27708008
NOC3_YEAST	NOC3	genetic	27708008
NSE1_YEAST	NSE1	genetic	27708008
SEC10_YEAST	SEC10	genetic	27708008
ORC1_YEAST	ORC1	genetic	27708008
POB3_YEAST	POB3	genetic	27708008
UTP15_YEAST	UTP15	genetic	27708008
DPOA_YEAST	POL1	genetic	27708008
PROF_YEAST	PFY1	genetic	27708008
PRS10_YEAST	RPT4	genetic	27708008
EXO84_YEAST	EXO84	genetic	27708008
PRP9_YEAST	PRP9	genetic	27708008
NOP14_YEAST	NOP14	genetic	27708008
NHP2_YEAST	NHP2	genetic	27708008
RRP1_YEAST	RRP1	genetic	27708008
SLU7_YEAST	SLU7	genetic	27708008
TCPA_YEAST	TCP1	genetic	27708008
GDI1_YEAST	GDI1	genetic	27708008
TBP_YEAST	SPT15	genetic	27708008
SEC4_YEAST	SEC4	genetic	27708008
MED6_YEAST	MED6	genetic	27708008
HACD_YEAST	PHS1	genetic	27708008
YJ9I_YEAST	YJR141W	genetic	27708008
NEP1_YEAST	EMG1	genetic	27708008
TAD3_YEAST	TAD3	genetic	27708008
DCP2_YEAST	DCP2	genetic	27708008
CAP_YEAST	SRV2	genetic	27708008
NOG2_YEAST	NOG2	genetic	27708008
NIP7_YEAST	NIP7	genetic	27708008
ATC3_YEAST	DRS2	genetic	27708008
HEK2_YEAST	HEK2	genetic	27708008
RXT2_YEAST	RXT2	genetic	27708008
BUD31_YEAST	BUD31	genetic	27708008
IMG2_YEAST	IMG2	genetic	27708008
NHP10_YEAST	NHP10	genetic	27708008
PP2C1_YEAST	PTC1	genetic	27708008
ATG20_YEAST	ATG20	genetic	27708008
SWF1_YEAST	SWF1	genetic	27708008
RLA4_YEAST	RPP2B	genetic	27708008
DOT1_YEAST	DOT1	genetic	27708008
BOI2_YEAST	BOI2	genetic	27708008
DDI1_YEAST	DDI1	genetic	27708008
BEM2_YEAST	BEM2	genetic	27708008
RAD4_YEAST	RAD4	genetic	27708008
CHAC_YEAST	GCG1	genetic	27708008
ODPA_YEAST	PDA1	genetic	27708008
LCL3_YEAST	LCL3	genetic	27708008
KEX1_YEAST	KEX1	genetic	27708008
RTF1_YEAST	RTF1	genetic	27708008
RTG2_YEAST	RTG2	genetic	27708008
YAP3_YEAST	YAP3	genetic	27708008
NEM1_YEAST	NEM1	genetic	27708008
MED20_YEAST	SRB2	genetic	27708008
OSH3_YEAST	OSH3	genetic	27708008
SOL3_YEAST	SOL3	genetic	27708008
PTH_YEAST	PTH1	genetic	27708008
SDS3_YEAST	SDS3	genetic	27708008
VPS53_YEAST	VPS53	genetic	27708008
SNX4_YEAST	SNX4	genetic	27708008
PIR5_YEAST	YJL160C	genetic	27708008
YJV3_YEAST	YJL213W	genetic	27708008
YJ24_YEAST	KCH1	genetic	27708008
DOHH_YEAST	LIA1	genetic	27708008
MOG1_YEAST	MOG1	genetic	27708008
CSN12_YEAST	YJR084W	genetic	27708008
VPS51_YEAST	VPS51	genetic	27708008
AIM29_YEAST	AIM29	genetic	27708008
DNM1_YEAST	DNM1	genetic	27708008
UBR2_YEAST	UBR2	genetic	27708008
ERG3_YEAST	ERG3	genetic	27708008
RL22A_YEAST	RPL22A	genetic	27708008
ENV10_YEAST	ENV10	genetic	27708008
RL37A_YEAST	RPL37A	genetic	27708008
CORO_YEAST	CRN1	genetic	27708008
ATG23_YEAST	ATG23	genetic	27708008
SST2_YEAST	SST2	genetic	27708008
UBX2_YEAST	UBX2	genetic	27708008
ATP18_YEAST	ATP18	genetic	27708008
SUB1_YEAST	SUB1	genetic	27708008
MUB1_YEAST	MUB1	genetic	27708008
SSO2_YEAST	SSO2	genetic	27708008
ERG2_YEAST	ERG2	genetic	27708008
SAP30_YEAST	SAP30	genetic	27708008
SCS7_YEAST	SCS7	genetic	27708008
SIW14_YEAST	SIW14	genetic	27708008
RL9B_YEAST	RPL9B	genetic	27708008
MKS1_YEAST	MKS1	genetic	27708008
PHO23_YEAST	PHO23	genetic	27708008
MSO1_YEAST	MSO1	genetic	27708008
SIN3_YEAST	SIN3	genetic	27708008
TLG2_YEAST	TLG2	genetic	27708008
SDHF2_YEAST	SDH5	genetic	27708008
INO4_YEAST	INO4	genetic	27708008
WHI5_YEAST	WHI5	genetic	27708008
ODC2_YEAST	ODC2	genetic	27708008
YO223_YEAST	DSC3	genetic	27708008
RS10A_YEAST	RPS10A	genetic	27708008
BUD7_YEAST	BUD7	genetic	27708008
SNC2_YEAST	SNC2	genetic	27708008
MNE1_YEAST	MNE1	genetic	27708008
NEW1_YEAST	NEW1	genetic	27708008
YAR1_YEAST	YAR1	genetic	27708008
OPI1_YEAST	OPI1	genetic	27708008
RS27B_YEAST	RPS27B	genetic	27708008
CAF20_YEAST	CAF20	genetic	27708008
SEC6_YEAST	SEC6	physical	25232005
SEC3_YEAST	SEC3	physical	25232005
SEC1_YEAST	SEC1	genetic	25232005
SEC4_YEAST	SEC4	genetic	25232005
EXO70_YEAST	EXO70	genetic	25313406

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SEC8_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, AND MASSSPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, AND MASSSPECTROMETRY.	17563356 [Abstract]