| UniProt ID | EAP1_YEAST | |
|---|---|---|
| UniProt AC | P36041 | |
| Protein Name | Protein EAP1 | |
| Gene Name | EAP1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 632 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Can regulate translation through binding to eIF4E. Competes with eIF4G and p20 for binding to eIF4E in vivo and inhibits cap-dependent translation in vitro. Plays a role in cell growth and is implicated in the TOR signaling cascade. Functions independently of eIF4E to maintain genetic stability and to attenuate GCN4 translation upon TOR inactivation.. | |
| Protein Sequence | MELNDPSIISSSQFSGELSDSDTAAATHKSQQAISNLFQKLAKKGREEKPIGSVESSTDSSNISVATSGNNKESNKKKNKKTAMLNFSSLTDPITNYKPMDLQYKTYAYSMNELYHLKPSLASASYEEDPLISELVRSLPKRKFWRLRMGPPDQKHANNHHFNGNNGGGSWKAGYKNGKNDERRMSRTKNMQGGKRRSQQDDEEKKIDQEMLEMDKNLQLGGDVGHSIADFEDWKAKMKELELKKLSKSKGISNSTAIAPRESASHETPTDLRPVIPRGPSSITDFLNLKRQDKKEESSQQTPGIPVGQPSLSKTSIEQVNELETNSDLGKSSSSRFSSFFNKSATSLPSLDNNNQVPSSNVSVVNNDGNSTPHQSGSRLMSFFKESRSSTPNAESQLLSASDKDNGKMQTLPQFQQQPQQMQPMAFTQHPPNNNAFFNGLLNKGKSETSTPPPPPPGLIAHQGPQFPVMGVPPNFPQRMMPPPPGLVQFQKDSKDVNKKEDRQLRQNKNPNGTRNSKGKQEETATPDLPQQQYMPPPPPPGFFPMHPNFPNGPMPPLPQGFPIPPNGMLPVTGQQPQPPYPNMMLQGNFPPNFQQGFGSNSPMPIPSIINANGKNVTNQLPPGLNSKKNIK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MELNDPSIISSSQF -CCCCCHHHCCCCCC | 35.10 | 30377154 | |
| 15 | Phosphorylation | IISSSQFSGELSDSD HCCCCCCCCCCCCCH | 24.58 | 22369663 | |
| 19 | Phosphorylation | SQFSGELSDSDTAAA CCCCCCCCCCHHHHH | 30.66 | 22369663 | |
| 21 | Phosphorylation | FSGELSDSDTAAATH CCCCCCCCHHHHHHH | 33.22 | 22369663 | |
| 23 | Phosphorylation | GELSDSDTAAATHKS CCCCCCHHHHHHHHH | 23.34 | 22369663 | |
| 27 | Phosphorylation | DSDTAAATHKSQQAI CCHHHHHHHHHHHHH | 25.72 | 22369663 | |
| 30 | Phosphorylation | TAAATHKSQQAISNL HHHHHHHHHHHHHHH | 21.66 | 22369663 | |
| 40 | Acetylation | AISNLFQKLAKKGRE HHHHHHHHHHHCCCC | 42.98 | 24489116 | |
| 186 | Phosphorylation | KNDERRMSRTKNMQG CCHHHHHHHHHCCCC | 34.68 | 27717283 | |
| 188 | Phosphorylation | DERRMSRTKNMQGGK HHHHHHHHHCCCCCC | 21.33 | 27717283 | |
| 198 | Phosphorylation | MQGGKRRSQQDDEEK CCCCCCCCCCCHHHH | 35.91 | 28889911 | |
| 227 | Phosphorylation | LGGDVGHSIADFEDW CCCCCCCCHHCHHHH | 17.34 | 22369663 | |
| 263 | Phosphorylation | TAIAPRESASHETPT CEECCCCCCCCCCCC | 36.03 | 28132839 | |
| 265 | Phosphorylation | IAPRESASHETPTDL ECCCCCCCCCCCCCC | 31.00 | 28889911 | |
| 268 | Phosphorylation | RESASHETPTDLRPV CCCCCCCCCCCCCCC | 26.51 | 21440633 | |
| 270 | Phosphorylation | SASHETPTDLRPVIP CCCCCCCCCCCCCCC | 55.90 | 21440633 | |
| 281 | Phosphorylation | PVIPRGPSSITDFLN CCCCCCCCCHHHHHH | 36.88 | 22369663 | |
| 282 | Phosphorylation | VIPRGPSSITDFLNL CCCCCCCCHHHHHHH | 32.42 | 22369663 | |
| 284 | Phosphorylation | PRGPSSITDFLNLKR CCCCCCHHHHHHHHH | 23.73 | 22890988 | |
| 290 | Acetylation | ITDFLNLKRQDKKEE HHHHHHHHHCCCCHH | 47.11 | 24489116 | |
| 298 | Phosphorylation | RQDKKEESSQQTPGI HCCCCHHHCCCCCCC | 34.24 | 22369663 | |
| 299 | Phosphorylation | QDKKEESSQQTPGIP CCCCHHHCCCCCCCC | 29.59 | 28132839 | |
| 302 | Phosphorylation | KEESSQQTPGIPVGQ CHHHCCCCCCCCCCC | 18.82 | 22369663 | |
| 311 | Phosphorylation | GIPVGQPSLSKTSIE CCCCCCCCCCCCCHH | 37.07 | 21440633 | |
| 313 | Phosphorylation | PVGQPSLSKTSIEQV CCCCCCCCCCCHHHH | 37.92 | 22369663 | |
| 315 | Phosphorylation | GQPSLSKTSIEQVNE CCCCCCCCCHHHHHH | 31.40 | 29136822 | |
| 316 | Phosphorylation | QPSLSKTSIEQVNEL CCCCCCCCHHHHHHH | 28.06 | 29136822 | |
| 325 | Phosphorylation | EQVNELETNSDLGKS HHHHHHHCCCCCCCC | 53.28 | 22369663 | |
| 327 | Phosphorylation | VNELETNSDLGKSSS HHHHHCCCCCCCCCH | 41.45 | 22369663 | |
| 332 | Phosphorylation | TNSDLGKSSSSRFSS CCCCCCCCCHHHHHH | 33.38 | 23749301 | |
| 333 | Phosphorylation | NSDLGKSSSSRFSSF CCCCCCCCHHHHHHH | 35.50 | 22369663 | |
| 334 | Phosphorylation | SDLGKSSSSRFSSFF CCCCCCCHHHHHHHH | 32.40 | 22369663 | |
| 335 | Phosphorylation | DLGKSSSSRFSSFFN CCCCCCHHHHHHHHC | 39.01 | 22369663 | |
| 338 | Phosphorylation | KSSSSRFSSFFNKSA CCCHHHHHHHHCCCC | 25.73 | 22369663 | |
| 339 | Phosphorylation | SSSSRFSSFFNKSAT CCHHHHHHHHCCCCC | 31.01 | 22369663 | |
| 344 | Phosphorylation | FSSFFNKSATSLPSL HHHHHCCCCCCCCCC | 37.57 | 22369663 | |
| 346 | Phosphorylation | SFFNKSATSLPSLDN HHHCCCCCCCCCCCC | 37.58 | 22369663 | |
| 347 | Phosphorylation | FFNKSATSLPSLDNN HHCCCCCCCCCCCCC | 37.69 | 22369663 | |
| 350 | Phosphorylation | KSATSLPSLDNNNQV CCCCCCCCCCCCCCC | 54.36 | 22369663 | |
| 359 | Phosphorylation | DNNNQVPSSNVSVVN CCCCCCCCCCEEEEC | 35.37 | 22369663 | |
| 360 | Phosphorylation | NNNQVPSSNVSVVNN CCCCCCCCCEEEECC | 34.87 | 22369663 | |
| 363 | Phosphorylation | QVPSSNVSVVNNDGN CCCCCCEEEECCCCC | 25.29 | 22369663 | |
| 371 | Phosphorylation | VVNNDGNSTPHQSGS EECCCCCCCCCCCHH | 49.17 | 22369663 | |
| 372 | Phosphorylation | VNNDGNSTPHQSGSR ECCCCCCCCCCCHHH | 28.88 | 22369663 | |
| 376 | Phosphorylation | GNSTPHQSGSRLMSF CCCCCCCCHHHHHHH | 35.38 | 22369663 | |
| 378 | Phosphorylation | STPHQSGSRLMSFFK CCCCCCHHHHHHHHH | 27.73 | 22369663 | |
| 382 | Phosphorylation | QSGSRLMSFFKESRS CCHHHHHHHHHHHHC | 31.93 | 22369663 | |
| 385 | Acetylation | SRLMSFFKESRSSTP HHHHHHHHHHHCCCC | 53.41 | 24489116 | |
| 387 | Phosphorylation | LMSFFKESRSSTPNA HHHHHHHHHCCCCCH | 37.74 | 22369663 | |
| 389 | Phosphorylation | SFFKESRSSTPNAES HHHHHHHCCCCCHHH | 48.09 | 22369663 | |
| 390 | Phosphorylation | FFKESRSSTPNAESQ HHHHHHCCCCCHHHH | 46.93 | 22369663 | |
| 391 | Phosphorylation | FKESRSSTPNAESQL HHHHHCCCCCHHHHH | 23.08 | 22369663 | |
| 396 | Phosphorylation | SSTPNAESQLLSASD CCCCCHHHHHHHCCC | 24.58 | 22890988 | |
| 400 | Phosphorylation | NAESQLLSASDKDNG CHHHHHHHCCCCCCC | 34.03 | 22369663 | |
| 402 | Phosphorylation | ESQLLSASDKDNGKM HHHHHHCCCCCCCCC | 41.64 | 22369663 | |
| 447 | Phosphorylation | GLLNKGKSETSTPPP CCCCCCCCCCCCCCC | 55.57 | 21440633 | |
| 449 | Phosphorylation | LNKGKSETSTPPPPP CCCCCCCCCCCCCCC | 45.02 | 28132839 | |
| 450 | Phosphorylation | NKGKSETSTPPPPPP CCCCCCCCCCCCCCC | 34.56 | 29136822 | |
| 451 | Phosphorylation | KGKSETSTPPPPPPG CCCCCCCCCCCCCCC | 47.43 | 21440633 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EAP1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EAP1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EAP1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30; SER-281; SER-282;THR-315; THR-325; SER-327; SER-344; SER-387 AND THR-391, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-281; SER-282; SER-344;THR-346 AND SER-390, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-281, AND MASSSPECTROMETRY. | |
