PHO91_YEAST - dbPTM
PHO91_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PHO91_YEAST
UniProt AC P27514
Protein Name Low-affinity phosphate transporter PHO91
Gene Name PHO91
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 894
Subcellular Localization Vacuole membrane
Multi-pass membrane protein .
Protein Description Vacuolar phosphate transporter that probably exports phosphate from the vacuolar lumen to the cytosol..
Protein Sequence MKFSHSLQFNSVPEWSTKYLAYSQLKKLIYSLQKDKLYSNNKHHVVEPHDANDENLPLLADASPDDQFYISKFVAALNQELKKIDKFYISQETGLIANYNELKDDVMELENTNKATQLFNQQQQHQLQSVARNRKSKSQQRQRRFSSVSSTDSNPSLTDMSIDSAPVIHTQVSNTTNNGNSMQNLASASVSLSNSNPVYLSPFTQHRLSLKKRLISIYTQLSELKDFIELNQTGFSKICKKFDKSLNTNLKQNYLNYIKFHSHVFNPATINRIQHHITETILTYASLNKGTRRPSNTFNLDADRINNDENSSGNEEDEDGNRQEVLDFQDAERELSSHLRDHVVWERNTVWKDMMNLERKYQSAKTDNKKFSKLSSSQLRPNANITESMAMSSGGAGIIAPSTDSLTFRELMHLPPKQWLQFIMGQTSLLKFLLITSCFIALLTFNLTPFTQDSLQKNCFAILIYASLLWATETIPLFVTSLMIPLLIVVFPVIKDPITSQPMSPRDSSQFILSTMWSSVIMLLLGGFTLAAALSKYNIAKVLSTHILASAGTNPHFILLTNMFVALFVSMWVSNVAAPVLCYSIVQPLLRTLPRNCSYAKALILGIALASNIGGMSSPIASPQNIFSIGIMDPSPSWAEWFMIALPVCFICVMAIWVLLIITFPPEPNVKILQLHPSRDPFTLKQWFVTLVCIITIVLWCLSNQISGIFGEMGIISIIPIVVFFGTGLLTSDDFNNFMWTIVVLAMGGTTLGKAVSSSGLLSTMAQLIKAQVEHEPIFIIVLIFGLVILVMATFVSHTVAAMIIVPLMSEIGSNLPSGDHSRLLIVIAALLCSSAMGLPTSGFPNVTAISMIDEVGDRYLTVGTFITRGVPASLLSYAAIVTVGYGILKVMGF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18AcetylationSVPEWSTKYLAYSQL
CCCHHHHHHHHHHHH		32.5224489116
19PhosphorylationVPEWSTKYLAYSQLK
CCHHHHHHHHHHHHH		9.1729688323
22PhosphorylationWSTKYLAYSQLKKLI
HHHHHHHHHHHHHHH		8.3829688323
23PhosphorylationSTKYLAYSQLKKLIY
HHHHHHHHHHHHHHH		24.3529688323
26SuccinylationYLAYSQLKKLIYSLQ
HHHHHHHHHHHHHHH		37.5923954790
88PhosphorylationLKKIDKFYISQETGL
HHHHCHHHHCCCCCC		12.8525533186
129PhosphorylationQQQHQLQSVARNRKS
HHHHHHHHHHHHHHC		26.7428889911
191PhosphorylationNLASASVSLSNSNPV
HHHHEEEECCCCCCE		24.4728889911
201PhosphorylationNSNPVYLSPFTQHRL
CCCCEECCCCHHHCH		10.5728889911
216PhosphorylationSLKKRLISIYTQLSE
HHHHHHHHHHHHHHH		17.7128889911
219PhosphorylationKRLISIYTQLSELKD
HHHHHHHHHHHHHHH		22.7428889911
222PhosphorylationISIYTQLSELKDFIE
HHHHHHHHHHHHHHH		30.9428889911
251AcetylationKSLNTNLKQNYLNYI
HHHCHHHHHHHHHHH		38.2724489116
295PhosphorylationNKGTRRPSNTFNLDA
CCCCCCCCCCCCCCH		46.8417330950
297PhosphorylationGTRRPSNTFNLDADR
CCCCCCCCCCCCHHH		20.4517330950
311PhosphorylationRINNDENSSGNEEDE
HCCCCCCCCCCCCCC		37.2617330950
312PhosphorylationINNDENSSGNEEDED
CCCCCCCCCCCCCCC		58.1617330950
427PhosphorylationLQFIMGQTSLLKFLL
HHHHHCHHHHHHHHH		18.6628132839
428PhosphorylationQFIMGQTSLLKFLLI
HHHHCHHHHHHHHHH		24.6628132839
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseRSP5P39940
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PHO91_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PHO91_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YNE6_YEASTYNL046Wgenetic
16269340
UBX2_YEASTUBX2genetic
16269340
BFR1_YEASTBFR1genetic
16269340
PHO84_YEASTPHO84genetic
17804816
PHO88_YEASTPHO88physical
16093310
MKAR_YEASTIFA38physical
16093310
CHS7_YEASTCHS7physical
16093310
ERG2_YEASTERG2genetic
21623372
RL2A_YEASTRPL2Aphysical
22940862
RL2B_YEASTRPL2Aphysical
22940862
HSP71_YEASTSSA1physical
22940862
HSP72_YEASTSSA2physical
22940862
SSB2_YEASTSSB2physical
22940862
SSB1_YEASTSSB1physical
22940862
RS3_YEASTRPS3physical
22940862
EF1A_YEASTTEF2physical
22940862
CDC37_YEASTCDC37genetic
27708008
TAD3_YEASTTAD3genetic
27708008
SWC3_YEASTSWC3genetic
27708008
SWD1_YEASTSWD1genetic
27708008
KIN3_YEASTKIN3genetic
27708008
HIR1_YEASTHIR1genetic
27708008
OLA1_YEASTOLA1genetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
SWC5_YEASTSWC5genetic
27708008
YCQ6_YEASTYCR016Wgenetic
27708008
ATG15_YEASTATG15genetic
27708008
RS29B_YEASTRPS29Bgenetic
27708008
S2538_YEASTYDL119Cgenetic
27708008
PCL2_YEASTPCL2genetic
27708008
RRP8_YEASTRRP8genetic
27708008
ARX1_YEASTARX1genetic
27708008
INO2_YEASTINO2genetic
27708008
NBP2_YEASTNBP2genetic
27708008
PEX5_YEASTPEX5genetic
27708008
APT2_YEASTAPT2genetic
27708008
AIM11_YEASTAIM11genetic
27708008
MIC19_YEASTMIC19genetic
27708008
RL9A_YEASTRPL9Agenetic
27708008
RTG2_YEASTRTG2genetic
27708008
TPC1_YEASTTPC1genetic
27708008
SYF2_YEASTSYF2genetic
27708008
RSSA1_YEASTRPS0Agenetic
27708008
TBP7_YEASTYTA7genetic
27708008
MED20_YEASTSRB2genetic
27708008
DAL81_YEASTDAL81genetic
27708008
INA22_YEASTINA22genetic
27708008
MOG1_YEASTMOG1genetic
27708008
RL43A_YEASTRPL43Bgenetic
27708008
RL43B_YEASTRPL43Bgenetic
27708008
TCTP_YEASTTMA19genetic
27708008
CYT2_YEASTCYT2genetic
27708008
MRP8_YEASTMRP8genetic
27708008
PAM17_YEASTPAM17genetic
27708008
MMR1_YEASTMMR1genetic
27708008
ARPC3_YEASTARC18genetic
27708008
COX8_YEASTCOX8genetic
27708008
TSA1_YEASTTSA1genetic
27708008
ATP18_YEASTATP18genetic
27708008
PLB1_YEASTPLB1genetic
27708008
MTND_YEASTADI1genetic
27708008
MLH1_YEASTMLH1genetic
27708008
CTL1_YEASTCTL1genetic
27708008
NOP12_YEASTNOP12genetic
27708008
CSK22_YEASTCKA2genetic
27708008
MUM3_YEASTMUM3genetic
27708008
SGE1_YEASTSGE1genetic
27708008
CDC15_YEASTCDC15genetic
27708008
TECR_YEASTTSC13genetic
27708008
ARP2_YEASTARP2genetic
27708008
KIN28_YEASTKIN28genetic
27708008
RPB1_YEASTRPO21genetic
27708008
PDC2_YEASTPDC2genetic
27708008
ACT_YEASTACT1genetic
27708008
CDC20_YEASTCDC20genetic
27708008
BIG1_YEASTBIG1genetic
27708008
FDFT_YEASTERG9genetic
27708008
TIM44_YEASTTIM44genetic
27708008
CDC16_YEASTCDC16genetic
27708008
HYM1_YEASTHYM1genetic
27708008
ERO1_YEASTERO1genetic
27708008
VTI1_YEASTVTI1genetic
27708008
GPI12_YEASTGPI12genetic
27708008
SMC5_YEASTSMC5genetic
27708008
TYSY_YEASTCDC21genetic
27708008
DYR_YEASTDFR1genetic
27708008
GPN2_YEASTGPN2genetic
27708008
PSB5_YEASTPRE2genetic
27708008
FUN26_YEASTFUN26genetic
27708008
RBG1_YEASTRBG1genetic
27708008
GEM1_YEASTGEM1genetic
27708008
RL19A_YEASTRPL19Bgenetic
27708008
RL19B_YEASTRPL19Bgenetic
27708008
SIF2_YEASTSIF2genetic
27708008
AGP2_YEASTAGP2genetic
27708008
YSW1_YEASTYSW1genetic
27708008
NPL4_YEASTNPL4genetic
27708008
AIM4_YEASTAIM4genetic
27708008
GLU2A_YEASTROT2genetic
27708008
LSB5_YEASTLSB5genetic
27708008
PAT1_YEASTPAT1genetic
27708008
SLX5_YEASTSLX5genetic
27708008
CRD1_YEASTCRD1genetic
27708008
OST4_YEASTOST4genetic
27708008
UBC5_YEASTUBC5genetic
27708008
RT103_YEASTRTT103genetic
27708008
LSM6_YEASTLSM6genetic
27708008
STP1_YEASTSTP1genetic
27708008
SWP82_YEASTSWP82genetic
27708008
ARO8_YEASTARO8genetic
27708008
RTF1_YEASTRTF1genetic
27708008
RT13_YEASTMRP13genetic
27708008
PSD2_YEASTPSD2genetic
27708008
YOR1_YEASTYOR1genetic
27708008
GLPK_YEASTGUT1genetic
27708008
PIH1_YEASTPIH1genetic
27708008
MSC7_YEASTMSC7genetic
27708008
LRP1_YEASTLRP1genetic
27708008
WSS1_YEASTWSS1genetic
27708008
RGI2_YEASTRGI2genetic
27708008
FMC1_YEASTFMC1genetic
27708008
6P21_YEASTPFK26genetic
27708008
VTC4_YEASTVTC4genetic
27708008
CUL8_YEASTRTT101genetic
27708008
MDM35_YEASTMDM35genetic
27708008
IRS4_YEASTIRS4genetic
27708008
VBA5_YEASTVBA5genetic
27708008
YL036_YEASTYLR036Cgenetic
27708008
APTH1_YEASTYLR118Cgenetic
27708008
DCN1_YEASTDCN1genetic
27708008
SKG3_YEASTSKG3genetic
27708008
SEC72_YEASTSEC72genetic
27708008
ELO3_YEASTELO3genetic
27708008
ATP10_YEASTATP10genetic
27708008
CG11_YEASTCLN1genetic
27708008
RNH1_YEASTRNH1genetic
27708008
SAP30_YEASTSAP30genetic
27708008
CAT8_YEASTCAT8genetic
27708008
SIN3_YEASTSIN3genetic
27708008
YO036_YEASTYOL036Wgenetic
27708008
PEX15_YEASTPEX15genetic
27708008
RTG1_YEASTRTG1genetic
27708008
RTC1_YEASTRTC1genetic
27708008
MRX11_YEASTYPL041Cgenetic
27708008
ELOC_YEASTELC1genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
DSS4_YEASTDSS4genetic
27708008
THP3_YEASTTHP3genetic
27708008
SPEE_YEASTSPE3genetic
27708008
VPS4_YEASTVPS4genetic
27708008
YP174_YEASTYPR174Cgenetic
27708008
OPT2_YEASTOPT2genetic
27708008
ARR2_YEASTARR2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PHO91_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-191; SER-201; SER-295;THR-297; SER-311 AND SER-312, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295; THR-297 ANDSER-312, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295; SER-311 ANDSER-312, AND MASS SPECTROMETRY.
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311 AND SER-312, ANDMASS SPECTROMETRY.

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