PLB1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLB1_YEAST
• UniProt AC: P39105
• Protein Name: Lysophospholipase 1 {ECO:0000303|PubMed:8051052}
• Gene Name: PLB1 {ECO:0000303|PubMed:8051052}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 664
• Subcellular Localization: Cell membrane ; Lipid-anchor, GPI-anchor .
• Protein Description: Sequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine > phosphatidylinositol >> phosphatidylcholine > phosphatidylethanolamine..
• Protein Sequence: MKLQSLLVSAAVLTSLTENVNAWSPNNSYVPANVTCDDDINLVREASGLSDNETEWLKKRDAYTKEALHSFLNRATSNFSDTSLLSTLFGSNSSNMPKIAVACSGGGYRAMLSGAGMLAAMDNRTDGANEHGLGGLLQGATYLAGLSGGNWLTSTLAWNNWTSVQAIVDNTTESNSIWDISHSILTPDGINIFKTGSRWDDISDDVQDKKDAGFNISLADVWGRALAYNFWPSLHRGGVGYTWSTLREADVFKNGEMPFPITVADGRYPGTTVINLNATLFEFNPFEMGSWDPTLNAFTDVKYLGTNVTNGKPVNKGQCIAGFDNTGFITATSSTLFNQFLLRLNSTDLPSFIANLATDFLEDLSDNSDDIAIYAPNPFKEANFLQKNATSSIIESEYLFLVDGGEDNQNIPLVPLLQKERELDVIFALDNSADTDDYWPDGASLVNTYQRQFGSQGLNLSFPYVPDVNTFVNLGLNKKPTFFGCDARNLTDLEYIPPLIVYIPNSRHSFNGNQSTFKMSYSDSERLGMIKNGFEAATMGNFTDDSDFLGCVGCAIIRRKQQNLNATLPSECSQCFTNYCWNGTIDSRSVSGVGNDDYSSSASLSASAAAASASASASASASASASGSSTHKKNAGNALVNYSNLNTNTFIGVLSVISAVFGLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	N-linked_Glycosylation	NVNAWSPNNSYVPAN CCCCCCCCCCCCCCC	44.56	-
33	N-linked_Glycosylation	NNSYVPANVTCDDDI CCCCCCCCEECCCCH	24.46	-
52	N-linked_Glycosylation	EASGLSDNETEWLKK HHHCCCCCCCHHHHH	55.50	-
65	Acetylation	KKRDAYTKEALHSFL HHCCCCHHHHHHHHH	28.45	24489116
78	N-linked_Glycosylation	FLNRATSNFSDTSLL HHHHHHCCCCHHHHH	35.77	-
87	Phosphorylation	SDTSLLSTLFGSNSS CHHHHHHHHHCCCCC	26.52	19779198
92	N-linked_Glycosylation	LSTLFGSNSSNMPKI HHHHHCCCCCCCCEE	50.24	-
93	Phosphorylation	STLFGSNSSNMPKIA HHHHCCCCCCCCEEE	25.45	19779198
94	Phosphorylation	TLFGSNSSNMPKIAV HHHCCCCCCCCEEEE	41.20	19779198
123	N-linked_Glycosylation	GMLAAMDNRTDGANE HHEEHHCCCCCCCCC	35.35	-
160	N-linked_Glycosylation	TSTLAWNNWTSVQAI CCCHHHCCCCCEEEE	32.47	-
170	N-linked_Glycosylation	SVQAIVDNTTESNSI CEEEEEECCCCCCCC	37.70	-
215	N-linked_Glycosylation	DKKDAGFNISLADVW CHHHCCCCEEHHHHH	23.25	-
277	N-linked_Glycosylation	GTTVINLNATLFEFN CCEEEECCCEEEEEC	26.79	-
307	N-linked_Glycosylation	DVKYLGTNVTNGKPV CCEECCCCCCCCCCC	36.50	-
345	N-linked_Glycosylation	NQFLLRLNSTDLPSF HHHHHHCCCCCHHHH	36.11	-
388	N-linked_Glycosylation	EANFLQKNATSSIIE HHCHHCCCCCCHHHC	35.17	-
459	N-linked_Glycosylation	QFGSQGLNLSFPYVP HHCCCCCCCCCCCCC	40.23	-
489	N-linked_Glycosylation	FFGCDARNLTDLEYI CCCCCCCCCCCHHHC	49.35	-
491	Phosphorylation	GCDARNLTDLEYIPP CCCCCCCCCHHHCCC	41.93	25371407
506	Phosphorylation	LIVYIPNSRHSFNGN EEEEECCCCCCCCCC	26.47	25371407
513	N-linked_Glycosylation	SRHSFNGNQSTFKMS CCCCCCCCCCEEEEE	33.46	-
520	Phosphorylation	NQSTFKMSYSDSERL CCCEEEEECCCHHHH	23.29	27017623
521	Phosphorylation	QSTFKMSYSDSERLG CCEEEEECCCHHHHE	17.01	27017623
522	Phosphorylation	STFKMSYSDSERLGM CEEEEECCCHHHHEE	27.61	27017623
524	Phosphorylation	FKMSYSDSERLGMIK EEEECCCHHHHEEEC	20.76	27017623
541	N-linked_Glycosylation	FEAATMGNFTDDSDF CCCCCCCCCCCCHHH	26.31	-
565	N-linked_Glycosylation	RRKQQNLNATLPSEC HHHHHCCCCCCCHHH	38.13	-
582	N-linked_Glycosylation	CFTNYCWNGTIDSRS HHCCCCCCCEECCCC	33.88	-
634	GPI-anchor	GSSTHKKNAGNALVN CCCCCCCCCCCEEEE	58.86	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLB1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLB1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLB1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PLB2_YEAST	PLB2	genetic	10497163
PLB2_YEAST	PLB2	genetic	10231538
ALE1_YEAST	ALE1	genetic	17890783
QCR7_YEAST	QCR7	genetic	21623372
PROA_YEAST	PRO2	genetic	21623372
MON2_YEAST	MON2	genetic	23891562
SRO7_YEAST	SRO7	genetic	23891562
CDC11_YEAST	CDC11	genetic	27708008
ERF3_YEAST	SUP35	genetic	27708008
SRPR_YEAST	SRP101	genetic	27708008
GPI11_YEAST	GPI11	genetic	27708008
RNA1_YEAST	RNA1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.