PROA_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PROA_YEAST
• UniProt AC: P54885
• Protein Name: Gamma-glutamyl phosphate reductase
• Gene Name: PRO2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 456
• Protein Description: Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate..
• Protein Sequence: MSSSQQIAKNARKAGNILKTISNEGRSDILYKIHDALKANAHAIEEANKIDLAVAKETGLADSLLKRLDLFKGDKFEVMLQGIKDVAELEDPVGKVKMARELDDGLTLYQVTAPVGVLLVIFESRPEVIANITALSIKSGNAAILKGGKESVNTFREMAKIVNDTIAQFQSETGVPVGSVQLIETRQDVSDLLDQDEYIDLVVPRGSNALVRKIKDTTKIPVLGHADGICSIYLDEDADLIKAKRISLDAKTNYPAGCNAMETLLINPKFSKWWEVLENLTLEGGVTIHATKDLKTAYFDKLNELGKLTEAIQCKTVDADEEQDFDKEFLSLDLAAKFVTSTESAIQHINTHSSRHTDAIVTENKANAEKFMKGVDSSGVYWNASTRFADGFRYGFGAEVGISTSKIHARGPVGLDGLVSYQYQIRGDGQVASDYLGAGGNKAFVHKDLDIKTVTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSSQQIAK ------CCHHHHHHH	38.40	22814378
2	Phosphorylation	------MSSSQQIAK ------CCHHHHHHH	38.40	30377154
3	Phosphorylation	-----MSSSQQIAKN -----CCHHHHHHHH	30.76	30377154
4	Phosphorylation	----MSSSQQIAKNA ----CCHHHHHHHHH	20.85	30377154
9	Acetylation	SSSQQIAKNARKAGN CHHHHHHHHHHHHHH	53.41	22865919
9	Succinylation	SSSQQIAKNARKAGN CHHHHHHHHHHHHHH	53.41	23954790
32	Acetylation	GRSDILYKIHDALKA CCCHHHHHHHHHHHH	30.07	24489116
38	Acetylation	YKIHDALKANAHAIE HHHHHHHHHCHHHHH	41.12	24489116
49	Acetylation	HAIEEANKIDLAVAK HHHHHHHCCCHHHHH	44.65	24489116
56	Acetylation	KIDLAVAKETGLADS CCCHHHHHHHCCHHH	49.57	24489116
66	Acetylation	GLADSLLKRLDLFKG CCHHHHHHHHCCCCC	57.09	24489116
66	Succinylation	GLADSLLKRLDLFKG CCHHHHHHHHCCCCC	57.09	23954790
66	2-Hydroxyisobutyrylation	GLADSLLKRLDLFKG CCHHHHHHHHCCCCC	57.09	-
72	Acetylation	LKRLDLFKGDKFEVM HHHHCCCCCCHHHHH	73.77	24489116
97	2-Hydroxyisobutyrylation	EDPVGKVKMARELDD CCCCCEEEEEEECCC	30.26	-
269	Acetylation	ETLLINPKFSKWWEV HHHEECCHHHHHHHH	58.75	24489116
295	2-Hydroxyisobutyrylation	IHATKDLKTAYFDKL EEECCCCCHHHHHHH	41.04	-
295	Acetylation	IHATKDLKTAYFDKL EEECCCCCHHHHHHH	41.04	24489116
295	Succinylation	IHATKDLKTAYFDKL EEECCCCCHHHHHHH	41.04	23954790
301	Acetylation	LKTAYFDKLNELGKL CCHHHHHHHHHHHHH	43.23	24489116
301	2-Hydroxyisobutyrylation	LKTAYFDKLNELGKL CCHHHHHHHHHHHHH	43.23	-
301	Ubiquitination	LKTAYFDKLNELGKL CCHHHHHHHHHHHHH	43.23	23749301
301	Succinylation	LKTAYFDKLNELGKL CCHHHHHHHHHHHHH	43.23	23954790
370	Acetylation	ENKANAEKFMKGVDS CCHHHHHHHHCCCCC	48.63	24489116
370	Ubiquitination	ENKANAEKFMKGVDS CCHHHHHHHHCCCCC	48.63	23749301
373	Acetylation	ANAEKFMKGVDSSGV HHHHHHHCCCCCCCC	59.94	24489116
433	Phosphorylation	RGDGQVASDYLGAGG CCCCCCCCCCCCCCC	28.12	28889911
435	Phosphorylation	DGQVASDYLGAGGNK CCCCCCCCCCCCCCC	12.44	28889911
442	Acetylation	YLGAGGNKAFVHKDL CCCCCCCCCEEECCC	46.61	24489116
447	Acetylation	GNKAFVHKDLDIKTV CCCCEEECCCCCEEE	55.47	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PROA_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PROA_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PROA_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDP2_YEAST	PTC6	physical	11805826
PEP3_YEAST	PEP3	physical	16554755
PROA_YEAST	PRO2	physical	18467557
PUT4_YEAST	PUT4	genetic	16941010
GAP1_YEAST	GAP1	genetic	16941010
NCPR_YEAST	NCP1	genetic	16941010
UCRI_YEAST	RIP1	genetic	16941010

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.