NCPR_YEAST - dbPTM
NCPR_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NCPR_YEAST
UniProt AC P16603
Protein Name NADPH--cytochrome P450 reductase {ECO:0000255|HAMAP-Rule:MF_03212}
Gene Name NCP1 {ECO:0000255|HAMAP-Rule:MF_03212}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 691
Subcellular Localization Endoplasmic reticulum membrane
Single-pass membrane protein
Cytoplasmic side . Mitochondrion outer membrane
Single-pass membrane protein
Cytoplasmic side . Cell membrane
Single-pass membrane protein
Cytoplasmic side .
Protein Description This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. Has NADPH-dependent ferrireductase activity on the plasma membrane..
Protein Sequence MPFGIDNTDFTVLAGLVLAVLLYVKRNSIKELLMSDDGDITAVSSGNRDIAQVVTENNKNYLVLYASQTGTAEDYAKKFSKELVAKFNLNVMCADVENYDFESLNDVPVIVSIFISTYGEGDFPDGAVNFEDFICNAEAGALSNLRYNMFGLGNSTYEFFNGAAKKAEKHLSAAGAIRLGKLGEADDGAGTTDEDYMAWKDSILEVLKDELHLDEQEAKFTSQFQYTVLNEITDSMSLGEPSAHYLPSHQLNRNADGIQLGPFDLSQPYIAPIVKSRELFSSNDRNCIHSEFDLSGSNIKYSTGDHLAVWPSNPLEKVEQFLSIFNLDPETIFDLKPLDPTVKVPFPTPTTIGAAIKHYLEITGPVSRQLFSSLIQFAPNADVKEKLTLLSKDKDQFAVEITSKYFNIADALKYLSDGAKWDTVPMQFLVESVPQMTPRYYSISSSSLSEKQTVHVTSIVENFPNPELPDAPPVVGVTTNLLRNIQLAQNNVNIAETNLPVHYDLNGPRKLFANYKLPVHVRRSNFRLPSNPSTPVIMIGPGTGVAPFRGFIRERVAFLESQKKGGNNVSLGKHILFYGSRNTDDFLYQDEWPEYAKKLDGSFEMVVAHSRLPNTKKVYVQDKLKDYEDQVFEMINNGAFIYVCGDAKGMAKGVSTALVGILSRGKSITTDEATELIKMLKTSGRYQEDVW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
41PhosphorylationMSDDGDITAVSSGNR
CCCCCCEEEECCCCC		26.2520377248
44PhosphorylationDGDITAVSSGNRDIA
CCCEEEECCCCCCEE		30.0227214570
45PhosphorylationGDITAVSSGNRDIAQ
CCEEEECCCCCCEEE		33.2224961812
59UbiquitinationQVVTENNKNYLVLYA
EEECCCCCCEEEEEE		59.5617644757
61PhosphorylationVTENNKNYLVLYASQ
ECCCCCCEEEEEEEC		10.3728889911
67PhosphorylationNYLVLYASQTGTAED
CEEEEEEECCCCHHH		18.0828889911
69PhosphorylationLVLYASQTGTAEDYA
EEEEEECCCCHHHHH		33.7228889911
75PhosphorylationQTGTAEDYAKKFSKE
CCCCHHHHHHHHHHH		16.3028889911
169AcetylationGAAKKAEKHLSAAGA
HHHHHHHHHHHHHHH		55.4922865919
172PhosphorylationKKAEKHLSAAGAIRL
HHHHHHHHHHHHHHC		18.7828889911
181UbiquitinationAGAIRLGKLGEADDG
HHHHHCCCCCCCCCC		58.8923749301
219UbiquitinationHLDEQEAKFTSQFQY
CCCHHHHHHCHHHHH		48.7119722269
275UbiquitinationPYIAPIVKSRELFSS
CEEEHHCCCHHHHCC		44.5117644757
281PhosphorylationVKSRELFSSNDRNCI
CCCHHHHCCCCCCCE		40.6427214570
350PhosphorylationKVPFPTPTTIGAAIK
CCCCCCCCHHHHHHH		33.2619779198
351PhosphorylationVPFPTPTTIGAAIKH
CCCCCCCHHHHHHHH		20.7219779198
367PhosphorylationLEITGPVSRQLFSSL
HHHHCHHHHHHHHHH		19.9019779198
384AcetylationFAPNADVKEKLTLLS
HCCCCCHHHHHHHHC		50.0724489116
394AcetylationLTLLSKDKDQFAVEI
HHHHCCCHHHHHHHH		58.1124489116
413AcetylationFNIADALKYLSDGAK
CCHHHHHHHHCCCCC		45.9624489116
444PhosphorylationTPRYYSISSSSLSEK
CCCEEEECCCCCCCC		20.4422369663
445PhosphorylationPRYYSISSSSLSEKQ
CCEEEECCCCCCCCC		23.4422369663
446PhosphorylationRYYSISSSSLSEKQT
CEEEECCCCCCCCCE		28.6222369663
447PhosphorylationYYSISSSSLSEKQTV
EEEECCCCCCCCCEE		37.5522369663
449PhosphorylationSISSSSLSEKQTVHV
EECCCCCCCCCEEEE		44.7022369663
451UbiquitinationSSSSLSEKQTVHVTS
CCCCCCCCCEEEEEE		48.1417644757
516AcetylationRKLFANYKLPVHVRR
CCEECCCCCCEEEEC		46.2324489116
561PhosphorylationERVAFLESQKKGGNN
HHHHHHHHHCCCCCC		49.8227017623
570PhosphorylationKKGGNNVSLGKHILF
CCCCCCCCCCCEEEE		33.2627017623
597AcetylationDEWPEYAKKLDGSFE
CCCHHHHHHCCCCEE		53.6324489116
597UbiquitinationDEWPEYAKKLDGSFE
CCCHHHHHHCCCCEE		53.6317644757
598UbiquitinationEWPEYAKKLDGSFEM
CCHHHHHHCCCCEEE		43.5717644757
666UbiquitinationVGILSRGKSITTDEA
HHHHHCCCCCCHHHH		37.2623749301
667PhosphorylationGILSRGKSITTDEAT
HHHHCCCCCCHHHHH		28.1721551504
678AcetylationDEATELIKMLKTSGR
HHHHHHHHHHHHCCC		51.2924489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NCPR_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NCPR_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NCPR_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RV161_YEASTRVS161physical
16554755
RV167_YEASTRVS167physical
16554755
NCB5R_YEASTCBR1genetic
17895367
STE24_YEASTSTE24physical
18467557
PIS_YEASTPIS1physical
18467557
PUT1_YEASTPUT1genetic
16941010
UCRI_YEASTRIP1genetic
16941010
PROB_YEASTPRO1genetic
16941010
SEO1_YEASTSEO1physical
16093310
FUR4_YEASTFUR4physical
16093310
TCM62_YEASTTCM62physical
16093310
AGP2_YEASTAGP2physical
16093310
DTR1_YEASTDTR1physical
16093310
SSU1_YEASTSSU1physical
16093310
TPS2_YEASTTPS2genetic
21623372
GGPPS_YEASTBTS1genetic
21623372
GSH1_YEASTGSH1genetic
21623372
TPS1_YEASTTPS1genetic
21623372
THRC_YEASTTHR4genetic
21623372
COQ3_YEASTCOQ3genetic
21623372
METX_YEASTYML082Wgenetic
21623372
ARO1_YEASTARO1genetic
21623372
KCS1_YEASTKCS1genetic
21623372
INP53_YEASTINP53genetic
21623372
JEN1_YEASTJEN1genetic
21623372
CEM1_YEASTCEM1genetic
21623372
CYS3_YEASTCYS3genetic
21623372
DHOM_YEASTHOM6genetic
21623372
CHO2_YEASTCHO2genetic
21623372
ELO3_YEASTELO3genetic
21623372
GPDM_YEASTGUT2genetic
21623372
SDT1_YEASTSDT1genetic
21623372
PFKA1_YEASTPFK1genetic
21623372
KPYK1_YEASTCDC19physical
22940862
SSB1_YEASTSSB1physical
22940862
HSP71_YEASTSSA1physical
22940862
HSP72_YEASTSSA2physical
22940862
HSP7F_YEASTSSE1physical
22940862
GMT1_YEASTVRG4genetic
23891562
ARP3_YEASTARP3genetic
23891562
GUP1_YEASTGUP1genetic
23891562
ERG3_YEASTERG3genetic
23891562
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NCPR_YEAST

loading...

Related Literatures of Post-Translational Modification
Ubiquitylation
ReferencePubMed
"A subset of membrane-associated proteins is ubiquitinated in responseto mutations in the endoplasmic reticulum degradation machinery.";
Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.;
Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-666, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory