| UniProt ID | PROB_YEAST | |
|---|---|---|
| UniProt AC | P32264 | |
| Protein Name | Glutamate 5-kinase | |
| Gene Name | PRO1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 428 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline.. | |
| Protein Sequence | MKDANESKSYTIVIKLGSSSLVDEKTKEPKLAIMSLIVETVVKLRRMGHKVIIVSSGGIAVGLRTMRMNKRPKHLAEVQAIAAIGQGRLIGRWDLLFSQFDQRIAQILLTRNDILDWTQYKNAQNTINELLNMGVIPIVNENDTLSVREIKFGDNDTLSAITSALIHADYLFLLTDVDCLYTDNPRTNPDAMPILVVPDLSKGLPGVNTAGGSGSDVGTGGMETKLVAADLATNAGVHTLIMKSDTPANIGRIVEYMQTLELDDENKVKQAYNGDLTDLQKREFEKLKALNVPLHTKFIANDNKHHLKNREFWILHGLVSKGAVVIDQGAYAALTRKNKAGLLPAGVIDVQGTFHELECVDIKVGKKLPDGTLDPDFPLQTVGKARCNYTSSELTKIKGLHSDQIEEELGYNDSEYVAHRENLAFPPR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 35 | Phosphorylation | EPKLAIMSLIVETVV CCHHHHHHHHHHHHH | 14.61 | 30377154 | |
| 40 | Phosphorylation | IMSLIVETVVKLRRM HHHHHHHHHHHHHHC | 21.50 | 30377154 | |
| 213 | Phosphorylation | GVNTAGGSGSDVGTG CCCCCCCCCCCCCCC | 33.92 | 30377154 | |
| 215 | Phosphorylation | NTAGGSGSDVGTGGM CCCCCCCCCCCCCCC | 30.71 | 30377154 | |
| 219 | Phosphorylation | GSGSDVGTGGMETKL CCCCCCCCCCCCEEE | 30.34 | 30377154 | |
| 297 | Acetylation | LNVPLHTKFIANDNK CCCCCCCEEECCCCC | 24.83 | 24489116 | |
| 367 | Acetylation | VDIKVGKKLPDGTLD EEEECCCCCCCCCCC | 60.36 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PROB_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PROB_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PROB_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GLE2_YEAST | GLE2 | physical | 11805826 | |
| PROB_YEAST | PRO1 | physical | 18467557 | |
| PROB_YEAST | PRO1 | physical | 18719252 | |
| PUT4_YEAST | PUT4 | genetic | 16941010 | |
| UCRI_YEAST | RIP1 | genetic | 16941010 | |
| PROB_YEAST | PRO1 | physical | 22615397 | |
| TREA_YEAST | NTH1 | genetic | 22280966 | |
| BRE5_YEAST | BRE5 | genetic | 27442630 | |
| UBP3_YEAST | UBP3 | genetic | 27442630 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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