dbPTM

SKG3_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SKG3_YEAST
UniProt AC	Q06315
Protein Name	Protein SKG3
Gene Name	SKG3
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	1026
Subcellular Localization	Cytoplasm . Bud neck . Cell membrane Peripheral membrane protein Cytoplasmic side .
Protein Description	May play a role in cell wall integrity..
Protein Sequence	MKRIFSGVKSPKLSAPPKVFKNDESPSTPSSPKFDQGLRSLSASASRLFSNSISTPGSPTLDLPQEHSINGDISPELVPIVTLLSAQAHRRYHYGIFLILHDLKTDGTPAARQWEECYGVLLGTQLALWDAKELSDSKNNKNTSTMKKAASRPSFINFTDASVRSLDANDQVIIASENEKTKKDLDNVLVVSTTLKNRYFLKFKNSKSFKTWNAAIRLSLFEFTALQEAYTGSFLSSRGVKLGDIKVVMADTKFTYEDWVSVRFGTGMPWKRCYAVISPQSGKKKKNSKGSICFYENNKKTKKSNIMTTVVDARALYAVYPSSPILIDTSTIIKLEGFVSFDKSEEPQETNLFIMPEKHQGVPGYDTIIRFLIPAMNAFYLYGRPKGLIANRTDPDSLLFALPTLPHIYYLQVDDVLSLTKDKNYIHWSAADWRNNIVQVLQKKLSKGYKGCGNKTVSVSSGMMKSPAISSAELFEGYDSLPERQMESPQKSKMKSPTLASTDDINSASASVNSHATSVKQTELFVTDNSSKINDSVSAQSSVTTNFKDTFTTPMTSGMLNHENSERSFGSGLKLKITDSNLENMEDVEAKSANEFSTTPEDKHIHLANAAELSALYDKYSTSPFGKSEANSSPKPQKLEVKDRSKNENRSPYERYVGTSAESKTFEIGNVRESKSTINTSLSSPLRVEDSRRSKNEDLGSLKEFEELSQKISNMGMANISSEALSDTAENSSFVTDLNLNINNSSSVNLNEEQRVPDFGEENVFDPDYMEQNQMLETESRYTTDEFDFSDNQDAASSNYSNGQTNRTVTETLSASDRNDKIPHSSLFTNLNQLTSNGGNYQDREDFSGDQINKPQQSQPLHVKGPQTSSFGYRNSSANSSQPQAPYPVGRPLGKIRTGPLTVQPMQQGGNSSMYSFQSSQHRFHSSQQRQNQSLSFRNNTYGSGNNQNTFHPSPQLQQQPQNMRYLNNKLPINDRSPIPQTQHHVPDGRPSLHINTTNRTNPLTAQSGFSQFMPPNSTSTNPYSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MKRIFSGVKSPKL --CCCCCCCCCCCCC	40.06	29136822
9	Acetylation	KRIFSGVKSPKLSAP CCCCCCCCCCCCCCC	65.65	25381059
10	Phosphorylation	RIFSGVKSPKLSAPP CCCCCCCCCCCCCCC	25.51	17330950
21	Ubiquitination	SAPPKVFKNDESPST CCCCCCCCCCCCCCC	67.49	23749301
25	Phosphorylation	KVFKNDESPSTPSSP CCCCCCCCCCCCCCC	27.32	22369663
27	Phosphorylation	FKNDESPSTPSSPKF CCCCCCCCCCCCCCH	63.33	25521595
28	Phosphorylation	KNDESPSTPSSPKFD CCCCCCCCCCCCCHH	30.49	25521595
30	Phosphorylation	DESPSTPSSPKFDQG CCCCCCCCCCCHHHH	60.40	25521595
31	Phosphorylation	ESPSTPSSPKFDQGL CCCCCCCCCCHHHHH	33.06	22369663
42	Phosphorylation	DQGLRSLSASASRLF HHHHHHHHHHHHHHH	22.79	23749301
44	Phosphorylation	GLRSLSASASRLFSN HHHHHHHHHHHHHCC	24.33	23749301
46	Phosphorylation	RSLSASASRLFSNSI HHHHHHHHHHHCCCC	27.33	28889911
54	Phosphorylation	RLFSNSISTPGSPTL HHHCCCCCCCCCCCC	28.50	23749301
58	Phosphorylation	NSISTPGSPTLDLPQ CCCCCCCCCCCCCCC	18.86	28889911
60	Phosphorylation	ISTPGSPTLDLPQEH CCCCCCCCCCCCCCC	34.30	23749301
68	Phosphorylation	LDLPQEHSINGDISP CCCCCCCCCCCCCCH	19.59	23749301
192	Phosphorylation	LDNVLVVSTTLKNRY HCCEEEEEEECCCCE	14.27	19823750
193	Phosphorylation	DNVLVVSTTLKNRYF CCEEEEEEECCCCEE	25.25	19823750
194	Phosphorylation	NVLVVSTTLKNRYFL CEEEEEEECCCCEEE	28.38	19823750
210	Acetylation	FKNSKSFKTWNAAIR ECCCCCHHHHHHHHH	60.77	24489116
323	Phosphorylation	LYAVYPSSPILIDTS HHHHCCCCCEEEECH	16.08	28889911
460	Phosphorylation	GNKTVSVSSGMMKSP CCCEEEECCCCCCCC	17.42	27017623
461	Phosphorylation	NKTVSVSSGMMKSPA CCEEEECCCCCCCCC	28.66	27017623
466	Phosphorylation	VSSGMMKSPAISSAE ECCCCCCCCCCCHHH	11.15	25752575
470	Phosphorylation	MMKSPAISSAELFEG CCCCCCCCHHHHHCC	26.12	28152593
471	Phosphorylation	MKSPAISSAELFEGY CCCCCCCHHHHHCCC	21.46	25752575
478	Phosphorylation	SAELFEGYDSLPERQ HHHHHCCCCCCCHHH	8.65	20377248
480	Phosphorylation	ELFEGYDSLPERQME HHHCCCCCCCHHHCC	37.02	25521595
488	Phosphorylation	LPERQMESPQKSKMK CCHHHCCCCCCCCCC	27.56	25521595
492	Phosphorylation	QMESPQKSKMKSPTL HCCCCCCCCCCCCCC	32.51	21440633
496	Phosphorylation	PQKSKMKSPTLASTD CCCCCCCCCCCCCCC	21.44	17330950
498	Phosphorylation	KSKMKSPTLASTDDI CCCCCCCCCCCCCCH	41.89	17330950
501	Phosphorylation	MKSPTLASTDDINSA CCCCCCCCCCCHHHC	35.17	19823750
502	Phosphorylation	KSPTLASTDDINSAS CCCCCCCCCCHHHCC	31.89	19823750
507	Phosphorylation	ASTDDINSASASVNS CCCCCHHHCCHHHHC	24.76	20377248
509	Phosphorylation	TDDINSASASVNSHA CCCHHHCCHHHHCCC	22.39	20377248
511	Phosphorylation	DINSASASVNSHATS CHHHCCHHHHCCCCC	21.24	20377248
514	Phosphorylation	SASASVNSHATSVKQ HCCHHHHCCCCCCCE	16.61	20377248
517	Phosphorylation	ASVNSHATSVKQTEL HHHHCCCCCCCEEEE	28.73	20377248
518	Phosphorylation	SVNSHATSVKQTELF HHHCCCCCCCEEEEE	28.27	22369663
522	Phosphorylation	HATSVKQTELFVTDN CCCCCCEEEEEECCC	29.01	19823750
527	Phosphorylation	KQTELFVTDNSSKIN CEEEEEECCCCCCCC	23.33	22369663
530	Phosphorylation	ELFVTDNSSKINDSV EEEECCCCCCCCCCC	35.50	22369663
531	Phosphorylation	LFVTDNSSKINDSVS EEECCCCCCCCCCCC	43.75	22369663
536	Phosphorylation	NSSKINDSVSAQSSV CCCCCCCCCCCCCCC	17.30	19795423
538	Phosphorylation	SKINDSVSAQSSVTT CCCCCCCCCCCCCCC	25.25	20377248
541	Phosphorylation	NDSVSAQSSVTTNFK CCCCCCCCCCCCCCC	26.88	22369663
542	Phosphorylation	DSVSAQSSVTTNFKD CCCCCCCCCCCCCCC	16.05	22369663
544	Phosphorylation	VSAQSSVTTNFKDTF CCCCCCCCCCCCCCC	20.26	20377248
545	Phosphorylation	SAQSSVTTNFKDTFT CCCCCCCCCCCCCCC	36.18	22369663
552	Phosphorylation	TNFKDTFTTPMTSGM CCCCCCCCCCCCCCC	31.89	29734811
553	Phosphorylation	NFKDTFTTPMTSGML CCCCCCCCCCCCCCC	13.58	21440633
556	Phosphorylation	DTFTTPMTSGMLNHE CCCCCCCCCCCCCCC	24.27	20377248
557	Phosphorylation	TFTTPMTSGMLNHEN CCCCCCCCCCCCCCC	18.89	20377248
565	Phosphorylation	GMLNHENSERSFGSG CCCCCCCCCCCCCCC	31.25	20377248
568	Phosphorylation	NHENSERSFGSGLKL CCCCCCCCCCCCCEE	29.88	20377248
571	Phosphorylation	NSERSFGSGLKLKIT CCCCCCCCCCEEEEE	38.65	20377248
578	Phosphorylation	SGLKLKITDSNLENM CCCEEEEECCCCCCH	31.61	22369663
580	Phosphorylation	LKLKITDSNLENMED CEEEEECCCCCCHHH	34.36	22369663
592	Phosphorylation	MEDVEAKSANEFSTT HHHHHHHHCCCCCCC	43.29	22369663
597	Phosphorylation	AKSANEFSTTPEDKH HHHCCCCCCCCCCCH	25.78	22890988
598	Phosphorylation	KSANEFSTTPEDKHI HHCCCCCCCCCCCHH	52.25	22369663
599	Phosphorylation	SANEFSTTPEDKHIH HCCCCCCCCCCCHHH	24.39	25521595
614	Phosphorylation	LANAAELSALYDKYS HCCHHHHHHHHHHHC	14.03	28889911
620	Phosphorylation	LSALYDKYSTSPFGK HHHHHHHHCCCCCCC	17.81	29688323
621	Phosphorylation	SALYDKYSTSPFGKS HHHHHHHCCCCCCCC	28.31	19779198
622	Phosphorylation	ALYDKYSTSPFGKSE HHHHHHCCCCCCCCC	37.01	21440633
623	Phosphorylation	LYDKYSTSPFGKSEA HHHHHCCCCCCCCCC	16.58	25521595
628	Phosphorylation	STSPFGKSEANSSPK CCCCCCCCCCCCCCC	42.17	21551504
632	Phosphorylation	FGKSEANSSPKPQKL CCCCCCCCCCCCCCC	55.88	22890988
633	Phosphorylation	GKSEANSSPKPQKLE CCCCCCCCCCCCCCC	36.43	17330950
635	Acetylation	SEANSSPKPQKLEVK CCCCCCCCCCCCCCC	63.13	25381059
638	Acetylation	NSSPKPQKLEVKDRS CCCCCCCCCCCCCCC	55.96	25381059
638	Ubiquitination	NSSPKPQKLEVKDRS CCCCCCCCCCCCCCC	55.96	23749301
651	Phosphorylation	RSKNENRSPYERYVG CCCCCCCCCCHHHCC	43.33	21440633
653	Phosphorylation	KNENRSPYERYVGTS CCCCCCCCHHHCCCC	17.81	19823750
656	Phosphorylation	NRSPYERYVGTSAES CCCCCHHHCCCCCCC	7.41	19823750
659	Phosphorylation	PYERYVGTSAESKTF CCHHHCCCCCCCCEE	18.08	17330950
660	Phosphorylation	YERYVGTSAESKTFE CHHHCCCCCCCCEEE	24.90	17330950
663	Phosphorylation	YVGTSAESKTFEIGN HCCCCCCCCEEEECC	36.39	17330950
665	Phosphorylation	GTSAESKTFEIGNVR CCCCCCCEEEECCEE	35.46	28889911
674	Phosphorylation	EIGNVRESKSTINTS EECCEECCCCEECCC	22.72	21440633
681	Phosphorylation	SKSTINTSLSSPLRV CCCEECCCCCCCCCH	23.05	21440633
683	Phosphorylation	STINTSLSSPLRVED CEECCCCCCCCCHHH	29.67	28889911
684	Phosphorylation	TINTSLSSPLRVEDS EECCCCCCCCCHHHH	32.99	21551504
691	Phosphorylation	SPLRVEDSRRSKNED CCCCHHHHCCCCCCC	18.98	28889911
694	Phosphorylation	RVEDSRRSKNEDLGS CHHHHCCCCCCCCCC	38.43	22369663
701	Phosphorylation	SKNEDLGSLKEFEEL CCCCCCCCHHHHHHH	43.49	22369663
709	Phosphorylation	LKEFEELSQKISNMG HHHHHHHHHHHHHCC	32.48	21440633
778	Phosphorylation	EQNQMLETESRYTTD HHHCCHHCCCCCCCC	34.99	28889911
790	Phosphorylation	TTDEFDFSDNQDAAS CCCCCCCCCCCCCHH	37.18	28889911
797	Phosphorylation	SDNQDAASSNYSNGQ CCCCCCHHCCCCCCC	22.34	27017623
798	Phosphorylation	DNQDAASSNYSNGQT CCCCCHHCCCCCCCC	34.75	28889911
800	Phosphorylation	QDAASSNYSNGQTNR CCCHHCCCCCCCCCC	12.88	19779198
801	Phosphorylation	DAASSNYSNGQTNRT CCHHCCCCCCCCCCC	38.44	23749301
805	Phosphorylation	SNYSNGQTNRTVTET CCCCCCCCCCCEEEE	28.24	30377154
812	Phosphorylation	TNRTVTETLSASDRN CCCCEEEECCHHHCC	19.35	30377154
814	Phosphorylation	RTVTETLSASDRNDK CCEEEECCHHHCCCC	32.90	28889911
816	Phosphorylation	VTETLSASDRNDKIP EEEECCHHHCCCCCC	33.45	25704821
825	Phosphorylation	RNDKIPHSSLFTNLN CCCCCCCHHHCCCHH	24.31	28889911
836	Phosphorylation	TNLNQLTSNGGNYQD CCHHHHHCCCCCCCC	41.91	28889911
869	Phosphorylation	HVKGPQTSSFGYRNS CCCCCCCCCCCCCCC	20.58	30377154
870	Phosphorylation	VKGPQTSSFGYRNSS CCCCCCCCCCCCCCC	26.52	30377154
877	Phosphorylation	SFGYRNSSANSSQPQ CCCCCCCCCCCCCCC	34.71	21440633
880	Phosphorylation	YRNSSANSSQPQAPY CCCCCCCCCCCCCCC	30.02	21440633
881	Phosphorylation	RNSSANSSQPQAPYP CCCCCCCCCCCCCCC	45.76	19779198
913	Phosphorylation	MQQGGNSSMYSFQSS CCCCCCCCCEEEHHH	26.24	23749301
916	Phosphorylation	GGNSSMYSFQSSQHR CCCCCCEEEHHHCCC	14.25	23749301
936	Phosphorylation	QRQNQSLSFRNNTYG HHCCCCCCCCCCCCC	27.66	30377154
942	Phosphorylation	LSFRNNTYGSGNNQN CCCCCCCCCCCCCCC	16.06	23749301
944	Phosphorylation	FRNNTYGSGNNQNTF CCCCCCCCCCCCCCC	28.12	28889911
950	Phosphorylation	GSGNNQNTFHPSPQL CCCCCCCCCCCCHHH	17.35	21440633
954	Phosphorylation	NQNTFHPSPQLQQQP CCCCCCCCHHHHHCC	19.39	23749301
970	Acetylation	NMRYLNNKLPINDRS HHHHHCCCCCCCCCC	55.34	24489116
1025	Phosphorylation	STSTNPYSS------ CCCCCCCCC------	30.72	30377154
1026	Phosphorylation	TSTNPYSS------- CCCCCCCC-------	38.10	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SKG3_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SKG3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SKG3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IMDH3_YEAST	IMD3	physical	16554755
HSP78_YEAST	HSP78	physical	19536198
HSP72_YEAST	SSA2	physical	19536198
HSP71_YEAST	SSA1	physical	19536198
SSB1_YEAST	SSB1	physical	19536198
CBF3B_YEAST	CEP3	genetic	27708008
PP2B1_YEAST	CNA1	physical	24930733
PP2B2_YEAST	CMP2	physical	24930733

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SKG3_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-30; SER-31;SER-58; SER-471; SER-518; SER-530; THR-578; SER-580; SER-592; THR-598;THR-599; SER-623; SER-684; SER-701 AND SER-801, AND MASS SPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; THR-578 AND SER-701,AND MASS SPECTROMETRY.	17563356 [Abstract]
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-633, AND MASSSPECTROMETRY.	17287358 [Abstract]
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10 AND SER-701, AND MASSSPECTROMETRY.	17330950 [Abstract]