LSB5_YEAST - dbPTM
LSB5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LSB5_YEAST
UniProt AC P25369
Protein Name LAS seventeen-binding protein 5
Gene Name LSB5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 354
Subcellular Localization Cytoplasm, cell cortex . Cytoplasm, cytoskeleton . Localizes independently of F-actin.
Protein Description Essential for the organization of the actin cytoskeleton, fluid phase endocytosis and vesicle trafficking, together with YSC84..
Protein Sequence MGFLSDHPHTAITETIFRIVSSRDYTLEVELAPLIQLIKADHNDYNYTVNQEEAARALRKKIKYGNRLQQSRTLDLLDLFISQGVKFTVMYNDDKLLQRLRGMATNSENSGSGEKYEPRIIKKCAAYAISWLNYITQNNLENARAYSGLYQLGQTVKQRYSKSSRSRRSGGGSGGRSNFMDDSADDTLYQSNSLTSADRLYRIPQINMNKEAPRIRLIISDALASAVSLQNSLIGLPKGKFSTDDEEATSKFIQARAIRRKVLRYLQLVTEGEFLGSLIHANDELVAALTAYDDRSAQDDSSDESDHGSYDDGIYDENEQDNSRYIDSESSEEESLSSYQPSTISNPFGDHNKI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MGFLSDHPHTAI
---CCCCCCCCCCCH		31.4530377154
10PhosphorylationFLSDHPHTAITETIF
CCCCCCCCCHHHHHH		24.9830377154
13PhosphorylationDHPHTAITETIFRIV
CCCCCCHHHHHHHHH		25.3130377154
15PhosphorylationPHTAITETIFRIVSS
CCCCHHHHHHHHHHC		19.4330377154
95AcetylationTVMYNDDKLLQRLRG
EEEECCHHHHHHHHH		54.6924489116
115UbiquitinationENSGSGEKYEPRIIK
CCCCCCCCCCHHHHH		59.4423749301
157UbiquitinationYQLGQTVKQRYSKSS
HHHHHHHHHHHCCCC		32.2323749301
162UbiquitinationTVKQRYSKSSRSRRS
HHHHHHCCCCCCCCC		43.4422817900
177PhosphorylationGGGSGGRSNFMDDSA
CCCCCCCCCCCCCCC		37.3822369663
183PhosphorylationRSNFMDDSADDTLYQ
CCCCCCCCCCCCHHH		29.3622369663
187PhosphorylationMDDSADDTLYQSNSL
CCCCCCCCHHHCCCC		28.1022369663
189PhosphorylationDSADDTLYQSNSLTS
CCCCCCHHHCCCCCC		16.4021440633
191PhosphorylationADDTLYQSNSLTSAD
CCCCHHHCCCCCCHH		18.1522369663
193PhosphorylationDTLYQSNSLTSADRL
CCHHHCCCCCCHHHH		37.9722369663
195PhosphorylationLYQSNSLTSADRLYR
HHHCCCCCCHHHHHC		22.9922369663
196PhosphorylationYQSNSLTSADRLYRI
HHCCCCCCHHHHHCC		33.2022369663
201PhosphorylationLTSADRLYRIPQINM
CCCHHHHHCCCCCCC		13.8522369663
210AcetylationIPQINMNKEAPRIRL
CCCCCCCCCCCCEEE		44.4724489116
210UbiquitinationIPQINMNKEAPRIRL
CCCCCCCCCCCCEEE		44.4723749301
251UbiquitinationDDEEATSKFIQARAI
CCHHHHHHHHHHHHH		41.9723749301
296PhosphorylationLTAYDDRSAQDDSSD
HHHCCCCCCCCCCCC		36.9622369663
301PhosphorylationDRSAQDDSSDESDHG
CCCCCCCCCCCCCCC		48.2322369663
302PhosphorylationRSAQDDSSDESDHGS
CCCCCCCCCCCCCCC		53.0122369663
305PhosphorylationQDDSSDESDHGSYDD
CCCCCCCCCCCCCCC		39.6422369663
309PhosphorylationSDESDHGSYDDGIYD
CCCCCCCCCCCCCCC		23.2022369663
310PhosphorylationDESDHGSYDDGIYDE
CCCCCCCCCCCCCCC		23.7322369663
315PhosphorylationGSYDDGIYDENEQDN
CCCCCCCCCCCCCCC		23.8022369663
323PhosphorylationDENEQDNSRYIDSES
CCCCCCCCCCCCCCC		34.4522369663
325PhosphorylationNEQDNSRYIDSESSE
CCCCCCCCCCCCCCC		14.6519779198
328PhosphorylationDNSRYIDSESSEEES
CCCCCCCCCCCCCHH		29.8019795423
330PhosphorylationSRYIDSESSEEESLS
CCCCCCCCCCCHHHH		47.1819779198
331PhosphorylationRYIDSESSEEESLSS
CCCCCCCCCCHHHHH		45.0019795423
335PhosphorylationSESSEEESLSSYQPS
CCCCCCHHHHHCCCC		36.5119795423
337PhosphorylationSSEEESLSSYQPSTI
CCCCHHHHHCCCCCC		35.9619779198
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LSB5_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LSB5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LSB5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SLA1_YEASTSLA1physical
15651983
LAS17_YEASTLAS17physical
15651983
ARF6_HUMANARF6physical
15651983
PEX22_YEASTPEX22genetic
27708008
ETR1_YEASTETR1genetic
27708008
NHP10_YEASTNHP10genetic
27708008
SLX5_YEASTSLX5genetic
27708008
ARO1_YEASTARO1genetic
27708008
SLX8_YEASTSLX8genetic
27708008
IES1_YEASTIES1genetic
27708008
MED20_YEASTSRB2genetic
27708008
IF4A_YEASTTIF2genetic
27708008
MRT4_YEASTMRT4genetic
27708008
ELM1_YEASTELM1genetic
27708008
MDM35_YEASTMDM35genetic
27708008
RS21A_YEASTRPS21Agenetic
27708008
UBI4P_YEASTUBI4genetic
27708008
VPS13_YEASTVPS13genetic
27708008
GBLP_YEASTASC1genetic
27708008
COX7_YEASTCOX7genetic
27708008
ATG3_YEASTATG3genetic
27708008
MDM38_YEASTMDM38genetic
27708008
VPS68_YEASTVPS68genetic
27708008
BECN1_YEASTVPS30genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
NEW1_YEASTNEW1genetic
27708008
OPY2_YEASTOPY2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LSB5_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-187; SER-193 ANDTHR-195, AND MASS SPECTROMETRY.

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