FUN26_YEAST - dbPTM
FUN26_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FUN26_YEAST
UniProt AC P31381
Protein Name Nucleoside transporter FUN26
Gene Name FUN26
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 517
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description Has broad nucleoside selectivity (uridine, adenosine and cytidine) and most likely functions to transport nucleosides across intracellular membranes..
Protein Sequence MSTSADTDTIKKPILAVPEPALADTHSEEISRSGEEHESENNEHSDEEGDNYSEREQSVSTEPLDTLPLRKKLKNLSYITFFAIGIGLLWPWNCILSASQYFKHDIFKDTSIWAKIFTSSMMSFSTISSMLFNIYLAKRQYKYSRRVINGLVWEIIVFTVMCFFTILHFLLPKWFNFMFIMMLVVISSMGTAMTQNGIMAIANVFGSEYSQGVMVGQAVAGVLPSLVLFALAFIENSSVSTTGGILLYFFTTTLVVTICVVMFSVSKISRKVNENWNVEDGHITDVLLGSLRSNEEEIRIVGRIDQMEDEDHRRTNGTRDDNDEGEELQLKVPFEVLFAKLKYLVLSIFTTFVVTLVFPVFASATYVTGLPLSNAQYIPLIFTLWNLGDLYGRVIADWPMFRDQKFTPRKTFIYSLLRVAAIPLFLMFTAITSSSSGDEEHNGSVIVDLCYMLLQFLFGVTNGHVISMSFMKVPEQLDNDDEKEAAGGFTNIFVSTGLALGSIISYVFVFIIDFIIR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSTSADTDT
------CCCCCCCCC		30.9422369663
3Phosphorylation-----MSTSADTDTI
-----CCCCCCCCCC		27.0022369663
4Phosphorylation----MSTSADTDTIK
----CCCCCCCCCCC		19.4822369663
7Phosphorylation-MSTSADTDTIKKPI
-CCCCCCCCCCCCCC		34.4622369663
9PhosphorylationSTSADTDTIKKPILA
CCCCCCCCCCCCCCC		36.4722369663
11UbiquitinationSADTDTIKKPILAVP
CCCCCCCCCCCCCCC		55.3724961812
12UbiquitinationADTDTIKKPILAVPE
CCCCCCCCCCCCCCC		33.1823749301
25PhosphorylationPEPALADTHSEEISR
CCCCCCCCCCHHHHC		22.9922369663
27PhosphorylationPALADTHSEEISRSG
CCCCCCCCHHHHCCC		38.7322369663
31PhosphorylationDTHSEEISRSGEEHE
CCCCHHHHCCCCCCC		24.5522369663
33PhosphorylationHSEEISRSGEEHESE
CCHHHHCCCCCCCCC		43.7119795423
39PhosphorylationRSGEEHESENNEHSD
CCCCCCCCCCCCCCC		47.7519795423
45PhosphorylationESENNEHSDEEGDNY
CCCCCCCCCCCCCCC		40.3019795423
52PhosphorylationSDEEGDNYSEREQSV
CCCCCCCCCHHHHHC		19.3519779198
53PhosphorylationDEEGDNYSEREQSVS
CCCCCCCCHHHHHCC		36.1128889911
58PhosphorylationNYSEREQSVSTEPLD
CCCHHHHHCCCCCCC		17.1822369663
60PhosphorylationSEREQSVSTEPLDTL
CHHHHHCCCCCCCCC		32.0922890988
61PhosphorylationEREQSVSTEPLDTLP
HHHHHCCCCCCCCCC		39.1922369663
66PhosphorylationVSTEPLDTLPLRKKL
CCCCCCCCCCHHHHH		37.6522890988
271UbiquitinationSVSKISRKVNENWNV
CHHHHHHHHHCCCCC		42.4917644757
293PhosphorylationVLLGSLRSNEEEIRI
HHHHHCCCCHHHHHE		54.6228889911
405UbiquitinationWPMFRDQKFTPRKTF
CCCCCCCCCCCCHHH		56.3323749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FUN26_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FUN26_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FUN26_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MKAR_YEASTIFA38physical
16093310
YHU0_YEASTYHR140Wphysical
16093310
STE24_YEASTSTE24physical
16093310
SYIC_YEASTILS1genetic
27708008
MAK5_YEASTMAK5genetic
27708008
UBC3_YEASTCDC34genetic
27708008
TAF12_YEASTTAF12genetic
27708008
TBP_YEASTSPT15genetic
27708008
MOB2_YEASTMOB2genetic
27708008
FDFT_YEASTERG9genetic
27708008
UTP9_YEASTUTP9genetic
27708008
ARP4_YEASTARP4genetic
27708008
SEC22_YEASTSEC22genetic
27708008
RPB1_YEASTRPO21genetic
27708008
PDC2_YEASTPDC2genetic
27708008
CDC1_YEASTCDC1genetic
27708008
NSE3_YEASTNSE3genetic
27708008
TFB1_YEASTTFB1genetic
27708008
RPB7_YEASTRPB7genetic
27708008
ACT_YEASTACT1genetic
27708008
COAD_YEASTCAB4genetic
27708008
CDC12_YEASTCDC12genetic
27708008
DNA2_YEASTDNA2genetic
27708008
PRI1_YEASTPRI1genetic
27708008
CDC6_YEASTCDC6genetic
27708008
MED14_YEASTRGR1genetic
27708008
CDC25_YEASTCDC25genetic
27708008
MCM1_YEASTMCM1genetic
27708008
LCB1_YEASTLCB1genetic
27708008
DPOA_YEASTPOL1genetic
27708008
TPT1_YEASTTPT1genetic
27708008
TYSY_YEASTCDC21genetic
27708008
MED4_YEASTMED4genetic
27708008
DYR_YEASTDFR1genetic
27708008
CLP1_YEASTCLP1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FUN26_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27, AND MASSSPECTROMETRY.

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